ID A1JNC7_YERE8 Unreviewed; 1115 AA.
AC A1JNC7;
DT 06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Potassium efflux system {ECO:0000313|EMBL:CAL13133.1};
GN Name=kefA {ECO:0000313|EMBL:CAL13133.1};
GN Synonyms=aefA {ECO:0000313|EMBL:CAL13133.1};
GN OrderedLocusNames=YE3097 {ECO:0000313|EMBL:CAL13133.1};
OS Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 /
OS 8081).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=393305 {ECO:0000313|EMBL:CAL13133.1, ECO:0000313|Proteomes:UP000000642};
RN [1] {ECO:0000313|EMBL:CAL13133.1, ECO:0000313|Proteomes:UP000000642}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 13174 / 8081 {ECO:0000313|Proteomes:UP000000642};
RX PubMed=17173484; DOI=10.1371/journal.pgen.0020206;
RA Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L.,
RA Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T.,
RA Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S.,
RA Sanders M., Whitehead S., Quail M.A., Dougan G., Parkhill J.,
RA Prentice M.B.;
RT "The complete genome sequence and comparative genome analysis of the high
RT pathogenicity Yersinia enterocolitica strain 8081.";
RL PLoS Genet. 2:2039-2051(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
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DR EMBL; AM286415; CAL13133.1; -; Genomic_DNA.
DR RefSeq; YP_001007280.1; NC_008800.1.
DR AlphaFoldDB; A1JNC7; -.
DR KEGG; yen:YE3097; -.
DR PATRIC; fig|393305.7.peg.3297; -.
DR eggNOG; COG3264; Bacteria.
DR eggNOG; COG4372; Bacteria.
DR HOGENOM; CLU_007829_3_0_6; -.
DR OrthoDB; 9799209at2; -.
DR Proteomes; UP000000642; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049142; MS_channel_1st.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR InterPro; IPR025692; MscS_IM_dom1.
DR InterPro; IPR024393; MscS_porin.
DR PANTHER; PTHR30347:SF8; MECHANOSENSITIVE CHANNEL MSCK; 1.
DR PANTHER; PTHR30347; POTASSIUM CHANNEL RELATED; 1.
DR Pfam; PF21088; MS_channel_1st; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR Pfam; PF12795; MscS_porin; 1.
DR Pfam; PF12794; MscS_TM; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 474..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 527..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..581
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 605..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 633..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 666..691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 703..722
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 772..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 815..835
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 856..877
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 889..917
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..263
FT /note="Mechanosensitive ion channel MscS porin"
FT /evidence="ECO:0000259|Pfam:PF12795"
FT DOMAIN 483..801
FT /note="Mechanosensitive ion channel inner membrane"
FT /evidence="ECO:0000259|Pfam:PF12794"
FT DOMAIN 862..903
FT /note="Mechanosensitive ion channel transmembrane helices
FT 2/3"
FT /evidence="ECO:0000259|Pfam:PF21088"
FT DOMAIN 905..970
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 980..1061
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
FT REGION 1081..1115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 49..139
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1115 AA; 125522 MW; 5C9EAA55F3954975 CRC64;
MLISPAIFAA GMNIDVPTRS EVLSQLDALS KQKILSPAEK LSQQDLTKTL EYLDTIERTK
QEAAQLKQQL AQAPAKLRQA TEELDALKNS SADTLTRESL SNYSLRQLES RLNETLDDLQ
SAQEDLSAYN SQLISLQTQP ERVQSAMYNA SMRLMQIRNQ LNGLAPNQEV LRPTQQQALL
TEQVMLNAQL DLQRKDLEAN TTLQDLLQKQ RDYTTAHINQ LERYVQLLQE VVSGKRLILS
EKTAKEAQAP NDATDIQNDP LVSRELAINK ELSQRLINAT KEGNTLVQQN IRVKNWLDRA
LQSERNLKEQ ITVLRGSLLL SRILYQQQLN LPASGLITNM GPRIADLRLE QFEINQQRDQ
LFQGDDYIQT LMTDSKEKVS PDVEDALGQI VDIRRELLDQ LNKQLGNQLT LAINLQINQQ
QLLSVNESLQ HTLTQQIFWV SSNKPMDWSW LKALPGAVKA ELSNFNFTLS WNDVLAGLMK
SLVFLIPMLI VVGVIRSRYK IINKHLDSLA ADVGQLKHDS QMHTPKAIML TLLKVLPGSL
IILGVGYWCL RSDFNLSDFF WSFFQRLALF WLVFDLTYRM LSPGGITERH FMIAADRCAH
YRRQMVRLGA ALLPVIFWSA LGEKSPLRLV DDVIGQVVIV IALALLALFV YPFCRDSWRE
KDSHAVRLVI VTAIAGTPII LIGLMVAGYF YTTLQLAGRW IDSLYLLFLW NIIYLTAIRG
LGVAARRLAY RRAIVRRQNL VKEGAEGGEP VEEPPLALEQ INQQSLRLTT MVLFLIFATC
FYAIWADLIT VISYLDSISL WHYTTTVAGA SVSQAVTLGN MLVALMALVV AYILTRNLPG
LLEVVVLSRL QLRQGTSYAI TTILTYLITA IGGITALSSL GVSWDKLQWL VAALSVGLGF
GLQEIFANFV SGLIILFERP VRIGDTVTIG TFSGNVNKIR IRATTITDFD RKEVIIPNKA
FVTERLINWS LSDTITRIII KVGVAYGSDL AKVKEILLKA AHENPRVMTD PEPHVFFLNF
GASTLDHELR VYVRELRDRS YTVDELNSAI DKLCRENDIN IAFNQLDVYL HKPDGTEIQE
VSRPFDTKEL PSVPSEKSAI GDTKPDLPDI NKPLA
//
