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Database: UniProt
Entry: A1KIK9
LinkDB: A1KIK9
Original site: A1KIK9 
ID   UVRC_MYCBP              Reviewed;         646 AA.
AC   A1KIK9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   11-JUN-2014, entry version 61.
DE   RecName: Full=UvrABC system protein C;
DE            Short=Protein UvrC;
DE   AltName: Full=Excinuclease ABC subunit C;
GN   Name=uvrC; OrderedLocusNames=BCG_1481;
OS   Mycobacterium bovis (strain BCG / Pasteur 1173P2).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=410289;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BCG / Pasteur 1173P2;
RX   PubMed=17372194; DOI=10.1073/pnas.0700869104;
RA   Brosch R., Gordon S.V., Garnier T., Eiglmeier K., Frigui W.,
RA   Valenti P., Dos Santos S., Duthoy S., Lacroix C., Garcia-Pelayo C.,
RA   Inwald J.K., Golby P., Garcia J.N., Hewinson R.G., Behr M.A.,
RA   Quail M.A., Churcher C., Barrell B.G., Parkhill J., Cole S.T.;
RT   "Genome plasticity of BCG and impact on vaccine efficacy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:5596-5601(2007).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides
CC       of the lesion. The N-terminal half is responsible for the 3'
CC       incision and the C-terminal half is responsible for the 5'
CC       incision (By similarity).
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the UvrC family.
CC   -!- SIMILARITY: Contains 1 GIY-YIG domain.
CC   -!- SIMILARITY: Contains 1 UVR domain.
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DR   EMBL; AM408590; CAL71468.1; -; Genomic_DNA.
DR   RefSeq; YP_977573.1; NC_008769.1.
DR   ProteinModelPortal; A1KIK9; -.
DR   SMR; A1KIK9; 14-101, 395-624.
DR   STRING; 410289.BCG_1481; -.
DR   EnsemblBacteria; CAL71468; CAL71468; BCG_1481.
DR   GeneID; 4696648; -.
DR   KEGG; mbb:BCG_1481; -.
DR   PATRIC; 18013718; VBIMycBov80988_1620.
DR   eggNOG; COG0322; -.
DR   HOGENOM; HOG000279962; -.
DR   KO; K03703; -.
DR   OMA; QTIASCV; -.
DR   OrthoDB; EOG6K13R9; -.
DR   BioCyc; MBOV410289:GJW7-1506-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   Gene3D; 4.10.860.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR027299; GIY-YIG_dom.
DR   InterPro; IPR000305; GIY-YIG_SF.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_homol_region.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; DNA damage; DNA excision; DNA repair;
KW   Excision nuclease; SOS response.
FT   CHAIN         1    646       UvrABC system protein C.
FT                                /FTId=PRO_1000077807.
FT   DOMAIN       16     95       GIY-YIG.
FT   DOMAIN      208    243       UVR.
SQ   SEQUENCE   646 AA;  71614 MW;  CD7792F6C54E6709 CRC64;
     MPDPATYRPA PGSIPVEPGV YRFRDQHGRV IYVGKAKSLR SRLTSYFADV ASLAPRTRQL
     VTTAAKVEWT VVGTEVEALQ LEYTWIKEFD PRFNVRYRDD KSYPVLAVTL GEEFPRLMVY
     RGPRRKGVRY FGPYSHAWAI RETLDLLTRV FPARTCSAGV FKRHRQIDRP CLLGYIDKCS
     APCIGRVDAA QHRQIVADFC DFLSGKTDRF ARALEQQMNA AAEQLDFERA ARLRDDLSAL
     KRAMEKQAVV LGDGTDADVV AFADDELEAA VQVFHVRGGR VRGQRGWIVE KPGEPGDSGI
     QLVEQFLTQF YGDQAALDDA ADESANPVPR EVLVPCLPSN AEELASWLSG LRGSRVVLRV
     PRRGDKRALA ETVHRNAEDA LQQHKLKRAS DFNARSAALQ SIQDSLGLAD APLRIECVDV
     SHVQGTDVVG SLVVFEDGLP RKSDYRHFGI REAAGQGRSD DVACIAEVTR RRFLRHLRDQ
     SDPDLLSPER KSRRFAYPPN LYVVDGGAPQ VNAASAVIDE LGVTDVAVIG LAKRLEEVWV
     PSEPDPIIMP RNSEGLYLLQ RVRDEAHRFA ITYHRSKRST RMTASALDSV PGLGEHRRKA
     LVTHFGSIAR LKEATVDEIT AVPGIGVATA TAVHDALRPD SSGAAR
//
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