ID A1KQS1_9BURK Unreviewed; 4085 AA.
AC A1KQS1;
DT 06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=RhiE protein {ECO:0000313|EMBL:CAL69893.1};
GN Name=rhiE {ECO:0000313|EMBL:CAL69893.1};
OS Mycetohabitans rhizoxinica.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Mycetohabitans.
OX NCBI_TaxID=412963 {ECO:0000313|EMBL:CAL69893.1};
RN [1] {ECO:0000313|EMBL:CAL69893.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B1 {ECO:0000313|EMBL:CAL69893.1};
RX PubMed=17154220; DOI=10.1002/cbic.200600393;
RA Partida-Martinez L.P., Hertweck C.;
RT "A gene cluster encoding rhizoxin biosynthesis in "Burkholderia rhizoxina",
RT the bacterial endosymbiont of the fungus Rhizopus microsporus.";
RL ChemBioChem 8:41-45(2007).
RN [2] {ECO:0007829|PDB:4KC5}
RP X-RAY CRYSTALLOGRAPHY (2.14 ANGSTROMS) OF 3045-3967.
RX PubMed=24048471; DOI=10.1038/nature12588;
RA Bretschneider T., Heim J.B., Heine D., Winkler R., Busch B., Kusebauch B.,
RA Stehle T., Zocher G., Hertweck C.;
RT "Vinylogous chain branching catalysed by a dedicated polyketide synthase
RT module.";
RL Nature 502:124-128(2013).
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DR EMBL; AM411073; CAL69893.1; -; Genomic_DNA.
DR PDB; 4KC5; X-ray; 2.14 A; A/B/C/D=3045-3967.
DR PDBsum; 4KC5; -.
DR SMR; A1KQS1; -.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08953; KR_2_SDR_x; 1.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 1.10.1240.100; -; 3.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 3.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 2.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 4.
DR Pfam; PF14765; PS-DH; 2.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 4.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00606; KS3_1; 2.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:4KC5};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 160..238
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 297..719
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1397..1474
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1506..1923
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2880..2953
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3055..3491
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 4005..4085
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 4085 AA; 446520 MW; EE38814DEA25C0D3 CRC64;
MAGMTAVEPL ASIYQISEQI HIGDSYRTLK ALYQRQDDGE ALSRITLAVS DDAESRHYSL
HPLLINSAFL TVIPLLASEQ LDSNFIPFGV KSLVLHRGQA PATGWIHTQL VKNSGELVLF
DAQLYGDDGV LVAEFSGCSL KRLRGSHLVD DKARRDSDSG CSREGIEDYL LAQLQALGAK
QIGKKQRHRN LMELGLESLQ LVNLTSRLES AAAIELEPTI FFEYPSVAEL ATFLWQEYKA
AFTPLLAGRS ETTDVAPVKT SVTPVKVSDA SPIAETCSMD ECVAHDSPKA VSGGDRQQDI
AIIGMQGQFG GADDLDQFWQ NIWQDRELIK EVPADHWDVA PWFDADPDAH DKTYSKWGSF
IDNVDKFDAD FFHLSRREAQ WMDPQVRLLL QSTYAAAENA GVIRQLRGSR TGVFIGSCFN
EYVDKITELG LPMDPYIATG SGVIAANRIS FWFDFKGPSL MFNTACSSSL VALHAACVSL
RNGECEMAFV GGSNLLLSSW HYRYFSAIRA LSPTGRCHTF DAQADGYVPG ECVAMLLLKP
LSKALADGDP IHGIIKGSAA LHGGYTPSLT APSVAGEENV IVHAWQDAGI DPRSLSYIEA
HGTGTKLGDP IEINALKRAF ARYTNDRGFC HIGSVKANIG HTEGAAGIAG VIKVLQQMKH
HKLPALGHFK QQNPHIKLDD SPLVIDREGR DWPEQSAPRR AGVSSFGFSG TNAHVVLQEY
REQREFATHQ GEKVLVPLSA RNASRLKEQV ARLLAYLAQH TPDLAALAYT LQTGREAMAT
RAIFMVDSVE QLRRQLQAWM AGEPGVDFGI ASMTAEEAVA AGDMRQLAAR WLAGAEEAEA
LDWTCLYGEG PRPARIGLPS YAFAKERYWL DAPAATVGQR ERAVTETTVA TETTVATYTE
QWQEVDEPGP GAPIKRLICL LSEPGLRQQL VQQVRALSAQ TELIFIAAGN RNERDDDGHY
RVAVDDPQQL QEGLQHALSA HGASRVLYLW SMDDRRWMID NSAIVALLKA MAATAAPIDR
LLLAGRAGDA LERCYLESWI GIERSLGAVM AHCPVEVAID LPDNTGDDSR WLRRLWLQLS
GDAAGGRLYQ SGRTFQLRLA STRATAAVEP LALEQINTLL ITGGLGGLGL LLAQDLSSRA
KRRSDGQLTL ILNGRSSLSA AQQAQLDSLR HDKCSIFYLQ ADCADRQAIA AALAEVLPQS
GPIDGLIHAA GLSAQGSLFD SAQADFDAVL HPKVKATLVL DEVLAAQPLA LICYFSSSSA
MLGDMGACSY AMANRFQQAY ARYAQAGRAR RVVAIHWPLW RNGGMAVGEQ ASTEFYLKSS
GQRMLENAEG LTLLQQIVAS DADHMLVLAG EPARLQQLVD GINDPARKAT ANSTVKATAA
QPMSERTRSR PELKGLSVEQ SLLWDLRDLA SRPLNAERHT LGEDTNLADF GFDSISLAEY
AGLLSRHLSL KLTPELFFSH STLAKIAAYL LAHHRQAVEA CYRGEVISAT EPLPIPAPVV
ASTSSADTIA IIGISGRFPG ARNADELWRV LAEGRDMVGE IPADRYDWRD YYGDHREDPS
KTRCIWMGSV PGVSEFDPMF FEISPREAKT LDPRQRLLLQ ESWNALEDAG VGPRHLETQR
VGMFVGVEEG DFQRLASEES LTSGHNGILA SRLAYFLNLT GPTMAINTAC SSALVALHQA
ALSLRNNECE IAVVAGVNLI FSPDAFIGMT QAGMLSPDGK CFAFDRRANG MVPGEAVCCV
VLKPLSRAEA DGDPIYGVLR GSGINYDGKT NGITAPSGAS QQRLLEEVYQ RAGMNTEAVE
YIVTHGTGTQ LGDPVEINAL NDAFRGNKPG HCALTSTKTN LGHTFAASGL VSVISLLQAF
RHETIPASLH CEQENDYIHW QQSPFYVNKT NKAWPAAGRD SERLGAVSAF GMSGTNAHVV
LESYSRERDA SPFRRPCYLF VLSAKTAEAL KEKIEQLSAA LQQGGYRDNQ LPSISYTLLE
GRHHFRHRLA LVAADLEEVL YTLAQYLAGE KRPNLFVGEV EREFSAQKTI ARYINQLLDD
SRNASEDETR ELLFGLADFY RQGYDIDGRR LFGAAQNGAH SMPPRLPLPG YPFAREHYWP
EGRRRQRQPT LVVNQPMERL HPLVHHNIST LATQRFVSRF SGRETFLADH RIGDQLIFPG
AAYLELAREA IVRASELPPQ QVTLQNVVWL RPLAFAVGGG DRDVELYCEL AVNGNDSVSF
RIYSLDGGTQ QLHAQGDAQL AAVAAPLPQP VDLAQWAARC NVSERSHDVL YHDFDTMGVH
YGVTFRAAGQ IRIGRDRVIG RLIHEALDPQ LEGVLLPPGV LDSALHIAAS LESRRQGAAE
PMLPFALESL RLYGSVEQAL RAGPLTVTAA YSEARGGGAI EKIDLQICND AGQCLVQLKG
FSSRKTGVEP QPAQAPVMAD SDEAADSDET LGRLIRTPFW KPVGSLGEWL PADAKPQLLL
LGLPETTVSE IRRQFGNQVS VLPGAPGEND AAAYQAAALA LLEWLQRLLS GHADGYLQLF
VGQGQDDLRL TALDAMLKTA MIENSALKAR LVALDPEMGN DAMVKVIVEQ SRYHSNELVR
VFANGSLYSR QWRELAPAQQ NEQAPLRDGG IYAITGGAGG LGLIFAEHIV SSCRNPVFYL
AGRSTVSQPL QQKADRLRAL GAQVHYQALD VGNAAAVRQW IDDIYAKEGS LHGVIHSAGV
IRDSMIINKP ASEFEQVLAA KVAGTEALDQ AINERALDFF VCCSSQAAMG NLGQVDYAAA
NAYMDAFMQY RQNLAGDGKR KGRSLSVNWP LWRDGGMKLA PVIEQQMRQR LGIVPMPVEE
GVKSLWQLLN NPVSAQGWVI YGESSRLTAI GQPVDAKPQA PAQPAPAAAT ASLSDSELKK
RIEAFVTRII ADVVQIDTAK IHPSEKFEVY GFDSIMAVGV TNELEKYLGS LPKTLLFEHV
NIAGMVDHFA VKYRDQFVAM FSASEEQQET SRGVQVSTVE HQVPTMKQSA VEPALAQSLP
LNRFAAAHSN ANSPAASSGT SIGSVAPVAP GTSVALGTSV ASGASGERVE DNELANYIAV
IGLGGYYPGA DSIDELWQNL ANGVDCMSDF PADRWDHSKI YYKNRKVLGK TTCINGSFIK
DVDKFDYSYF KMPKVYADHM SPEVRLFLQV AVHTFEDAGY SKETLLSRYN GDVGVLLGTM
SNDYHYYGFE SNVFRGSMAS GSGMATIPMT VSYFYGLTGP SLFIDTMCSS SSTCIHTACQ
MLKHDETKMV LAGGLNLMYH PYTTVNTSQG NFTSITSESV NSYGVGADGT VIGEGIGAVL
LKRLDRAIAD RDQIYGVIKG SAMTNAGERN GFNVPNPDLQ TLAIRQAMDQ AKVHPSSISY
IEGHGSGTKL GDPIEVLGLN NAFRWATDDK QFCYLGSIKS NIGHLLAASG IAGLTKTLLQ
FKHKQIAPSI HSSQLNQDID FADTPFVVPQ QLIEWRQPER IINGRKQVFP RRAGLTSIAA
GGMNAHMIVE EYPEPADSAG QISEDQLVFV FSVHKLALLA QNLTSFRDWL ASSEAPLAQI
AYTLQVGKNN LRNRLAIRCR TRQALSRALN ACIDGHYQSS ADSKIFYRFQ ESDAVQPLES
DLNDPLAPLL TQWLNGDSQV DWASLYAQPP VRISLPAYRF EKTRCWYTEE GYESSIVNPL
MFKNKLHPLV AKNCSTPQPG AIFRTDFVED ELLDYVYSGR GGRRLSAFNF ADVALAMPAL
ASRFDGRTLS VSCAFEHYIA DWTTVTGLEY RLFEIDSEQL ELEFDFRRSG EQPTHLGFAV
INPLTSDEPP LPQQWLDDAR ELLNRQALQA GRQLSAAEVS QRLAQAGYDF APYLDHDGEL
TIGRSGLVLK GRPPVNRHNH YADNVQLSPY LATTIDKALY LLLDELGLPQ GRVIVRNIER
LCCYHTPAGG FSVVLSGIGL NDNELSLSLL VLDEREQICV KLDKVSLYLG KQEVASVDRK
HSLLTGTVEM ANMPAAVLAR PLLEPAGQPT TARVEKQEAK PQADDSEAGF GEKILAFIQQ
ELQDKLGFAA QDIGESTQVH DLGLDSIMVV QLTDSVNKRF GTKLMPDLFY EKQQLGELVA
RLEAA
//
