ID A1KSW4_NEIMF Unreviewed; 691 AA.
AC A1KSW4;
DT 06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Competence protein {ECO:0000313|EMBL:CAM09945.1};
GN Name=comA {ECO:0000313|EMBL:CAM09945.1};
GN OrderedLocusNames=NMC0652 {ECO:0000313|EMBL:CAM09945.1};
OS Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM
OS 15464 / FAM18).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=272831 {ECO:0000313|EMBL:CAM09945.1, ECO:0000313|Proteomes:UP000002286};
RN [1] {ECO:0000313|EMBL:CAM09945.1, ECO:0000313|Proteomes:UP000002286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700532 / DSM 15464 / FAM18
RC {ECO:0000313|Proteomes:UP000002286};
RX PubMed=17305430; DOI=10.1371/journal.pgen.0030023;
RA Bentley S.D., Vernikos G.S., Snyder L.A.S., Churcher C., Arrowsmith C.,
RA Chillingworth T., Cronin A., Davis P.H., Holroyd N.E., Jagels K.,
RA Maddison M., Moule S., Rabbinowitsch E., Sharp S., Unwin L., Whitehead S.,
RA Quail M.A., Achtman M., Barrell B., Saunders N.J., Parkhill J.;
RT "Meningococcal genetic variation mechanisms viewed through comparative
RT analysis of serogroup C strain FAM18.";
RL PLoS Genet. 3:230-240(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AM421808; CAM09945.1; -; Genomic_DNA.
DR AlphaFoldDB; A1KSW4; -.
DR KEGG; nmc:NMC0652; -.
DR HOGENOM; CLU_010363_3_0_4; -.
DR Proteomes; UP000002286; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 179..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 455..633
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 691 AA; 74288 MW; 930B42376F0EB3D2 CRC64;
MLCVLAGAAY GVFRTEAALS SQWRAEAVSG VPLTVEVADM PRSDGRRVQF AAKAVDSGGR
TFDLLLSDYK RREWAVGSRW RITARVHPVV GELNLRGLNR EAWALSNGIG GAGTVGADRV
LLHGGSGWGI AVWRSRISRN WQQADADGGL SDGIGLMRAL SVGEQSALRP ELWQAFRPLG
LTHLVSISGL HVTMVAVMFA WLAKRLLACS PRLPARPRAW VLAAGCAGAL FYALLAGFSV
PTQRSVLMLA AFAWAWRRGR LSAWATWWQA LAAVLLFDPS AVLGVGTWLS FGLVAALIWA
CSGRLHEGKR QTAVRGQWAA SVLSLVLLGY LFASLPLISP LVNAVAIPWF SWVLTPLALL
GSVVPFAPLQ QLGAFLAEYT LRFLVWLADV SPEFAVAAAP LPLLVLAVCA ALLLLLPRGL
GLRPWAVLLL AGFVFYRSPG VPENEVAVTV WDAGQGLSVS VQTANHHLLF DTGTAAAAQM
GIVPSLNAAG VRRLDKLVLS HHDSDHDGGF QAVGKIPNGG IYAGQPEFYE GARHCAEQRW
QWDGVDFEFL MPSERKNIDD NGKSCVLRVV AGGAALLVTG DLDTKGEESL VGKYGGNLYS
QVLVLGHHGS NTSSSGVFLN AVSPEYAVAS SGYANAYKHP TEAVQNRIRA HGIKLLRTDL
SGALQFGLGR GGVKAQRLRG YKFYWQKKPF E
//
