ID A1L1P5_DANRE Unreviewed; 531 AA.
AC A1L1P5; A0A0N4SU73; A0A8M1NBT7; F1QMJ2;
DT 06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 131.
DE SubName: Full=UDP glucuronosyltransferase 5 family, polypeptide B4 {ECO:0000313|Ensembl:ENSDARP00000074773, ECO:0000313|RefSeq:NP_001074161.1};
DE SubName: Full=Zgc:158224 {ECO:0000313|EMBL:AAI29163.1};
GN Name=ugt5b4 {ECO:0000313|Ensembl:ENSDARP00000074773,
GN ECO:0000313|RefSeq:NP_001074161.1,
GN ECO:0000313|ZFIN:ZDB-GENE-070112-2332};
GN Synonyms=Ugt5b3 {ECO:0000313|RefSeq:NP_001074161.1}, zgc:158224
GN {ECO:0000313|RefSeq:NP_001074161.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI29163.1};
RN [1] {ECO:0000313|EMBL:AAI29163.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney {ECO:0000313|EMBL:AAI29163.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001074161.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20161780; DOI=10.1371/journal.pone.0009144;
RA Huang H., Wu Q.;
RT "Cloning and comparative analyses of the zebrafish Ugt repertoire reveal
RT its evolutionary diversity.";
RL PLoS ONE 5:E9144-E9144(2010).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000074773}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000074773};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [4] {ECO:0000313|Ensembl:ENSDARP00000074773, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000074773};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|RefSeq:NP_001074161.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24728488;
RA Wang Y., Huang H., Wu Q.;
RT "Characterization of the zebrafish Ugt repertoire reveals a new class of
RT drug-metabolizing UDP glucuronosyltransferases.";
RL Mol. Pharmacol. 86:62-75(2014).
RN [6] {ECO:0000313|RefSeq:NP_001074161.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [7] {ECO:0000313|Ensembl:ENSDARP00000137720}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000106357};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [8] {ECO:0000313|RefSeq:NP_001074161.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CU104756; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC129162; AAI29163.1; -; mRNA.
DR RefSeq; NP_001074161.1; NM_001080692.1.
DR STRING; 7955.ENSDARP00000074773; -.
DR CAZy; GT1; Glycosyltransferase Family 1.
DR Ensembl; ENSDART00000080323.6; ENSDARP00000074773.3; ENSDARG00000091916.5.
DR Ensembl; ENSDART00000121490.3; ENSDARP00000111534.1; ENSDARG00000091916.5.
DR Ensembl; ENSDART00000127735.3; ENSDARP00000106357.2; ENSDARG00000091916.5.
DR Ensembl; ENSDART00000160474.2; ENSDARP00000137720.2; ENSDARG00000091916.5.
DR GeneID; 791210; -.
DR KEGG; dre:791210; -.
DR AGR; ZFIN:ZDB-GENE-070112-2332; -.
DR CTD; 791210; -.
DR ZFIN; ZDB-GENE-070112-2332; ugt5b4.
DR HOGENOM; CLU_012949_3_2_1; -.
DR OMA; YLACIRI; -.
DR OrthoDB; 382054at2759; -.
DR TreeFam; TF315472; -.
DR Proteomes; UP000000437; Chromosome 1.
DR Bgee; ENSDARG00000091916; Expressed in liver and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008194; F:UDP-glycosyltransferase activity; IBA:GO_Central.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1.
DR InterPro; IPR002213; UDP_glucos_trans.
DR PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR PANTHER; PTHR48043:SF52; UDP GLUCURONOSYLTRANSFERASE 5 FAMILY POLYPEPTIDE B1-RELATED; 1.
DR Pfam; PF00201; UDPGT; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 2: Evidence at transcript level;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001074161.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..531
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001074161.1"
FT /id="PRO_5035034612"
FT TRANSMEM 495..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 531 AA; 60578 MW; 2FC0BF7D7DD1A92E CRC64;
MNRKVFHMLW PVTLCLLLVM APVVESGNVL VFPVDGSHWV NMNILVEALH AKGHNITVIR
MSDSWYIKEF SPHYTSITLK SSGGFSEDIL ETFASRLITI LRDGSTWGRL KLEMEMWQSS
LKIMETEREM IINMIEDQQL IDSLKKTKYD LFLTDPAMYG GVILGNYLKL PIVYNVRWAI
FGEGHFVIAP SPLSYVPVAM LELPDRMSFL ERVKNVVMYI ITETQIAFLI APTYNVLCER
FIGPGVNLFN LVQGADLWLH RADFVFEYPR PTMPNIVYMA GFQCKPSKPL PKDLEDFVQS
SGDHGVIVMS LGTIIGQLPD DVAEAIAEAF AELPQKIIWR YKGKRPSALG NNTLIMDWMP
QNDLLGHPKT RAFVAHGGTN GVQEAIYHGV PIIGFGLIFD QPDNLSKMRV RGAAKNVDFA
TMDKESFLKT VKEVLYDPSY RENMQRLSRL HKDVPVKPLD NAIFWIEFVM RHKGAAHLRT
ESYKMPWYSY HSVDVILVLI SAVSLIILSI YAVIRYFCCK ICMRKTKIKR Q
//
