ID SUCC_PYRIL Reviewed; 382 AA.
AC A1RTB8;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 01-MAY-2013, entry version 52.
DE RecName: Full=Succinyl-CoA ligase [ADP-forming] subunit beta;
DE EC=6.2.1.5;
DE AltName: Full=Succinyl-CoA synthetase subunit beta;
DE Short=SCS-beta;
GN Name=sucC; OrderedLocusNames=Pisl_1026;
OS Pyrobaculum islandicum (strain DSM 4184 / JCM 9189).
OC Archaea; Crenarchaeota; Thermoprotei; Thermoproteales;
OC Thermoproteaceae; Pyrobaculum.
OX NCBI_TaxID=384616;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 4184 / JCM 9189;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Dalin E., Tice H., Pitluck S., Meincke L.,
RA Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Lowe T.,
RA Richardson P.;
RT "Complete sequence of Pyrobaculum islandicum DSM 4184.";
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: ATP + succinate + CoA = ADP + phosphate +
CC succinyl-CoA.
CC -!- COFACTOR: Binds 1 magnesium or manganese ion per subunit (By
CC similarity).
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC succinate from succinyl-CoA (ligase route): step 1/1.
CC -!- SUBUNIT: Heterotetramer of two alpha and two beta subunits (By
CC similarity).
CC -!- SIMILARITY: Belongs to the succinate/malate CoA ligase beta
CC subunit family.
CC -!- SIMILARITY: Contains 1 ATP-grasp domain.
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DR EMBL; CP000504; ABL88200.1; -; Genomic_DNA.
DR RefSeq; YP_930543.1; NC_008701.1.
DR ProteinModelPortal; A1RTB8; -.
DR STRING; 384616.Pisl_1026; -.
DR EnsemblBacteria; ABL88200; ABL88200; Pisl_1026.
DR GeneID; 4616320; -.
DR KEGG; pis:Pisl_1026; -.
DR eggNOG; COG0045; -.
DR HOGENOM; HOG000007059; -.
DR KO; K01903; -.
DR OMA; TQNKQFT; -.
DR ProtClustDB; PRK00696; -.
DR UniPathway; UPA00223; UER00999.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR GO; GO:0030145; F:manganese ion binding; IEA:HAMAP.
DR GO; GO:0004775; F:succinate-CoA ligase (ADP-forming) activity; IEA:HAMAP.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:HAMAP.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.30.470.20; -; 1.
DR Gene3D; 3.40.50.261; -; 1.
DR HAMAP; MF_00558; Succ_CoA_beta; 1; -.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013650; ATP-grasp_succ-CoA_synth-type.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR013816; ATP_grasp_subdomain_2.
DR InterPro; IPR005811; CoA_ligase.
DR InterPro; IPR017866; Succ-CoA_synthase_bsu_CS.
DR InterPro; IPR005809; Succ_CoA_synthase_bsu.
DR InterPro; IPR016102; Succinyl-CoA_synth-like.
DR PANTHER; PTHR11815; PTHR11815; 1.
DR Pfam; PF08442; ATP-grasp_2; 1.
DR Pfam; PF00549; Ligase_CoA; 1.
DR PIRSF; PIRSF001554; SucCS_beta; 1.
DR SUPFAM; SSF52210; CoA_ligase; 1.
DR TIGRFAMs; TIGR01016; sucCoAbeta; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS01217; SUCCINYL_COA_LIG_3; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Ligase; Magnesium; Manganese;
KW Metal-binding; Nucleotide-binding; Tricarboxylic acid cycle.
FT CHAIN 1 382 Succinyl-CoA ligase [ADP-forming] subunit
FT beta.
FT /FTId=PRO_1000082182.
FT DOMAIN 9 240 ATP-grasp.
FT NP_BIND 35 100 ATP (By similarity).
FT METAL 191 191 Magnesium or manganese (By similarity).
FT METAL 193 193 Magnesium or manganese (By similarity).
SQ SEQUENCE 382 AA; 42355 MW; 06E2854D9DBA68B9 CRC64;
MKLHEYEAKE LFLRYGVKIP PGKLALTPDE VRKIAEEIGT PVVLKAQVVV AGRGKAGGIK
IAQTPEEAYE LSKKMFGMNI KGLVVRKLYV TKYVEVEREM YLSLIIDRAS RRYLFLASPI
GGVDIEEIAK TSPEKIKKVY VDPSIGLRDY HIRSIISWLG FKPGSQQWQQ TASVIQAMYR
IMVDYDAELV ETNPLALSKE GEVIPLDARV IVDDNALFKH PDLEKALEED PRDITEFEAY
AKKIGFHYVE LDGDIGIIGN GAGLTMATMD LVYHFGGRPA NFLDIGGGAS REVVKEAVKV
LLNHPRVKVI FVNIFGGITR ADEVALGIKD ALAEVKEHTK KIVVRIKGTN EEQGKAILSE
IGIPLFENAE EAAKKAVELA KI
//
