ID A1SH63_NOCSJ Unreviewed; 467 AA.
AC A1SH63;
DT 06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Dihydropyrimidinase {ECO:0000313|EMBL:ABL81148.1};
DE EC=3.5.2.2 {ECO:0000313|EMBL:ABL81148.1};
GN OrderedLocusNames=Noca_1635 {ECO:0000313|EMBL:ABL81148.1};
OS Nocardioides sp. (strain ATCC BAA-499 / JS614).
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=196162 {ECO:0000313|EMBL:ABL81148.1, ECO:0000313|Proteomes:UP000000640};
RN [1] {ECO:0000313|Proteomes:UP000000640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-499 / JS614 {ECO:0000313|Proteomes:UP000000640};
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J.,
RA Richardson P.;
RT "Complete sequence of chromosome 1 of Nocardioides sp. JS614.";
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABL81148.1, ECO:0000313|Proteomes:UP000000640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-499 / JS614 {ECO:0000313|Proteomes:UP000000640};
RX PubMed=21551312; DOI=10.1128/JB.05109-11;
RA Coleman N.V., Wilson N.L., Barry K., Brettin T.S., Bruce D.C., Copeland A.,
RA Dalin E., Detter J.C., Del Rio T.G., Goodwin L.A., Hammon N.M., Han S.,
RA Hauser L.J., Israni S., Kim E., Kyrpides N., Land M.L., Lapidus A.,
RA Larimer F.W., Lucas S., Pitluck S., Richardson P., Schmutz J., Tapia R.,
RA Thompson S., Tice H.N., Spain J.C., Gossett J.G., Mattes T.E.;
RT "Genome Sequence of the ethene- and vinyl chloride-oxidizing actinomycete
RT Nocardioides sp. strain JS614.";
RL J. Bacteriol. 193:3399-3400(2011).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- PTM: Carbamylation allows a single lysine to coordinate two divalent
CC metal cations. {ECO:0000256|PIRSR:PIRSR611778-50}.
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Hydantoinase/dihydropyrimidinase family.
CC {ECO:0000256|ARBA:ARBA00008829}.
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DR EMBL; CP000509; ABL81148.1; -; Genomic_DNA.
DR RefSeq; WP_011755095.1; NC_008699.1.
DR AlphaFoldDB; A1SH63; -.
DR STRING; 196162.Noca_1635; -.
DR KEGG; nca:Noca_1635; -.
DR eggNOG; COG0044; Bacteria.
DR HOGENOM; CLU_015572_2_0_11; -.
DR OrthoDB; 9775759at2; -.
DR Proteomes; UP000000640; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004157; F:dihydropyrimidinase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 2.30.40.10; Urease, subunit C, domain 1; 1.
DR InterPro; IPR006680; Amidohydro-rel.
DR InterPro; IPR011778; Hydantoinase/dihydroPyrase.
DR InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR InterPro; IPR032466; Metal_Hydrolase.
DR NCBIfam; TIGR02033; D-hydantoinase; 1.
DR PANTHER; PTHR11647:SF99; D-PHENYLHYDANTOINASE-RELATED; 1.
DR PANTHER; PTHR11647; HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER; 1.
DR Pfam; PF01979; Amidohydro_1; 1.
DR SUPFAM; SSF51338; Composite domain of metallo-dependent hydrolases; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:ABL81148.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000640}.
FT DOMAIN 54..443
FT /note="Amidohydrolase-related"
FT /evidence="ECO:0000259|Pfam:PF01979"
FT MOD_RES 156
FT /note="N6-carboxylysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR611778-50"
SQ SEQUENCE 467 AA; 48561 MW; 4F36840BE78FE674 CRC64;
MSNDLVVRGG TVVDGAGTRR ADVLVRAGRI VAVEPEIALD SAAAADIVDA GGAYVVPGGI
DVHTHFALPV GAVTSADDFE SGTLAAACGG TTCVVDFAGA GREPWQEALA TWHDRARDRA
VVDYGFHLTV AELPEDPEAA VARFGEFVEH GVTSVKLYLA YPDRLMVDDD TLARALAAGR
RTGVRVCVHA EDGATVESLV VEALAAGRKG PDAIPAVRPD SVEAEAIRRA AVLAAAADTS
LYVVHLSSAA GLEAVRAARA VGADVHAETC PHYLYLDQAH LEAGEPDFVC APPLRGAADR
AALWGAIAAG EVEVVATDHC PFTRADRRRG TGGDGWADFR QLPGGLSGVE TRLALAYQGV
VSGRLTLGRW VEVTSGAPAR LFGLAGVKGS VRPGLDADLV VFDPGATRVL DAATLHSRCD
HSPYEGLVVT GWPALTLSRG EVVAAAGEPV EPRPGRGRFV RRSPIVH
//
