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Database: UniProt
Entry: A1T5Z3
LinkDB: A1T5Z3
Original site: A1T5Z3 
ID   AROA_MYCVP              Reviewed;         446 AA.
AC   A1T5Z3;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   01-OCT-2014, entry version 62.
DE   RecName: Full=3-phosphoshikimate 1-carboxyvinyltransferase {ECO:0000255|HAMAP-Rule:MF_00210};
DE            EC=2.5.1.19 {ECO:0000255|HAMAP-Rule:MF_00210};
DE   AltName: Full=5-enolpyruvylshikimate-3-phosphate synthase {ECO:0000255|HAMAP-Rule:MF_00210};
DE            Short=EPSP synthase {ECO:0000255|HAMAP-Rule:MF_00210};
DE            Short=EPSPS {ECO:0000255|HAMAP-Rule:MF_00210};
GN   Name=aroA {ECO:0000255|HAMAP-Rule:MF_00210};
GN   OrderedLocusNames=Mvan_1771;
OS   Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium.
OX   NCBI_TaxID=350058;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 7251 / PYR-1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Singan V., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Anderson I.J., Miller C., Richardson P.;
RT   "Complete sequence of Mycobacterium vanbaalenii PYR-1.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Phosphoenolpyruvate + 3-phosphoshikimate =
CC       phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate.
CC       {ECO:0000255|HAMAP-Rule:MF_00210}.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 6/7. {ECO:0000255|HAMAP-Rule:MF_00210}.
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00210}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00210}.
CC   -!- SIMILARITY: Belongs to the EPSP synthase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00210}.
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DR   EMBL; CP000511; ABM12593.1; -; Genomic_DNA.
DR   RefSeq; YP_952599.1; NC_008726.1.
DR   ProteinModelPortal; A1T5Z3; -.
DR   SMR; A1T5Z3; 1-428.
DR   STRING; 350058.Mvan_1771; -.
DR   EnsemblBacteria; ABM12593; ABM12593; Mvan_1771.
DR   GeneID; 4647067; -.
DR   KEGG; mva:Mvan_1771; -.
DR   PATRIC; 18181775; VBIMycVan31953_1817.
DR   eggNOG; COG0128; -.
DR   HOGENOM; HOG000247373; -.
DR   KO; K00800; -.
DR   OMA; SYDDHRM; -.
DR   OrthoDB; EOG6Z6FZ4; -.
DR   BioCyc; MVAN350058:GIWR-1780-MONOMER; -.
DR   UniPathway; UPA00053; UER00089.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003866; F:3-phosphoshikimate 1-carboxyvinyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.65.10.10; -; 2.
DR   HAMAP; MF_00210; EPSP_synth; 1.
DR   InterPro; IPR001986; Enolpyruvate_Tfrase_dom.
DR   InterPro; IPR006264; EPSP_synthase.
DR   InterPro; IPR023193; EPSP_synthase_CS.
DR   InterPro; IPR013792; RNA3'P_cycl/enolpyr_Trfase_a/b.
DR   Pfam; PF00275; EPSP_synthase; 1.
DR   PIRSF; PIRSF000505; EPSPS; 1.
DR   SUPFAM; SSF55205; SSF55205; 1.
DR   TIGRFAMs; TIGR01356; aroA; 1.
DR   PROSITE; PS00104; EPSP_SYNTHASE_1; 1.
DR   PROSITE; PS00885; EPSP_SYNTHASE_2; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Cytoplasm; Reference proteome; Transferase.
FT   CHAIN         1    446       3-phosphoshikimate 1-
FT                                carboxyvinyltransferase.
FT                                /FTId=PRO_1000099729.
SQ   SEQUENCE   446 AA;  45498 MW;  F8AA5380D085C48B CRC64;
     MSTWPAPSTA TPVHATVTVP GSKSQTNRAL VLAALAVPQG SSTISGALRS RDTDLMISAL
     QGLGVVVEAP DTDGSDGTEL TVSGALAPKA GARIDCGLAG TVLRFVPPVA ALTTETVTFD
     GDEQARARPI APLLDGLRAL GVAIDGDGLP FSVRGQGSVR GGTVEIDASG SSQFVSGLLL
     SGAAFTEGLT VVHTGGAVPS APHIAMTVSM LRDAGVEVDD SAADRWRVAP GPIAARHWAV
     EPDLSNAVPF LAAAVISGGT VRVTGWPTVS TQPAATILSL LTSLGSEVRQ GNSHLEVQGA
     TSYDGIDVDL RDVGELAPSV AAMAALASPG SVSRLRGIAH LRGHETDRLA ALSAELNRLG
     GQCEETDDGL VITARQMHGG VWRSYADHRM ATAGAIVGLR VPGVEVEDIG TTAKTLPDFP
     QLWADMLAGQ TDLQAGAPHA GRNQGR
//
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