ID GLPK_MYCVP Reviewed; 505 AA.
AC A1TGD7;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 01-MAY-2013, entry version 49.
DE RecName: Full=Glycerol kinase;
DE EC=2.7.1.30;
DE AltName: Full=ATP:glycerol 3-phosphotransferase;
DE AltName: Full=Glycerokinase;
DE Short=GK;
GN Name=glpK; OrderedLocusNames=Mvan_5467;
OS Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Mycobacteriaceae; Mycobacterium.
OX NCBI_TaxID=350058;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 7251 / PYR-1;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA Pitluck S., Singan V., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Anderson I.J., Miller C., Richardson P.;
RT "Complete sequence of Mycobacterium vanbaalenii PYR-1.";
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Key enzyme in the regulation of glycerol uptake and
CC metabolism (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP + glycerol = ADP + sn-glycerol 3-
CC phosphate.
CC -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol
CC kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC -!- SIMILARITY: Belongs to the FGGY kinase family.
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DR EMBL; CP000511; ABM16237.1; -; Genomic_DNA.
DR RefSeq; YP_956243.1; NC_008726.1.
DR ProteinModelPortal; A1TGD7; -.
DR SMR; A1TGD7; 2-505.
DR STRING; 350058.Mvan_5467; -.
DR EnsemblBacteria; ABM16237; ABM16237; Mvan_5467.
DR GeneID; 4645206; -.
DR KEGG; mva:Mvan_5467; -.
DR PATRIC; 18189353; VBIMycVan31953_5569.
DR eggNOG; COG0554; -.
DR HOGENOM; HOG000222134; -.
DR KO; K00864; -.
DR OMA; PDGGLHV; -.
DR ProtClustDB; PRK00047; -.
DR BioCyc; MVAN350058:GIWR-5518-MONOMER; -.
DR UniPathway; UPA00618; UER00672.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0004370; F:glycerol kinase activity; IEA:HAMAP.
DR GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:HAMAP.
DR HAMAP; MF_00186; Glycerol_kin; 1; -.
DR InterPro; IPR018485; Carb_kinase_FGGY_C.
DR InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR InterPro; IPR018484; Carb_kinase_FGGY_N.
DR InterPro; IPR005999; Glycerol_kin.
DR PANTHER; PTHR10196:SF9; PTHR10196:SF9; 1.
DR Pfam; PF02782; FGGY_C; 1.
DR Pfam; PF00370; FGGY_N; 1.
DR TIGRFAMs; TIGR01311; glycerol_kin; 1.
DR PROSITE; PS00933; FGGY_KINASES_1; 1.
DR PROSITE; PS00445; FGGY_KINASES_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Glycerol metabolism; Kinase;
KW Nucleotide-binding; Transferase.
FT CHAIN 1 505 Glycerol kinase.
FT /FTId=PRO_1000020749.
FT NP_BIND 416 420 ATP (By similarity).
FT BINDING 12 12 Substrate (By similarity).
FT BINDING 16 16 ATP (By similarity).
FT BINDING 82 82 Substrate (By similarity).
FT BINDING 134 134 Substrate (By similarity).
FT BINDING 249 249 Substrate (By similarity).
FT BINDING 271 271 ATP (By similarity).
FT BINDING 315 315 ATP; via carbonyl oxygen (By similarity).
SQ SEQUENCE 505 AA; 54920 MW; 9F313CD8F573FFFE CRC64;
MADFVAAIDQ GTTSTRCMIF DHDGAEVGRH QLEHEQILPR AGWVEHNPVE IWERTGSVLA
TALNKTKLST SDLVALGITN QRETSLVWNR HTGRPYYNAI VWQDTRTDRI ASALDRDGRG
DVIRQKAGLP PATYFSGGKL QWLLENVDGL RADAEKGDAL FGTTDTWVLW NLTGGHRGGV
HVTDVTNASR TMLMNLETLD WDDELLGFFD IPRQMLPEIR PSSSPEPHGV TVDWGPADGE
IPVTGILGDQ QAAMVGQVCL DAGEAKNTYG TGNFLLLNTG ENIVRSKNGL LTTVCYQFGD
AKPVYALEGS IAVTGSAVQW LRDQLGIISG AAQSESLARQ VEDNGGVYFV PAFSGLFAPY
WRSDARGAIV GLSRFNTNAH VARATLEAIC YQSRDVVDAM AADSGVHLEV LKVDGGITAN
DLCMQIQADV LGVDVVRPVV AETTALGAAY AAGLAVGFWD GADDLRANWQ EDKRWSPTWS
DDQRAAGYAG WRKAVQRTMD WVDVD
//
