ID A1UNL2_MYCSK Unreviewed; 772 AA.
AC A1UNL2;
DT 06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=MMPL domain protein {ECO:0000313|EMBL:ABL94420.1};
GN OrderedLocusNames=Mkms_5231 {ECO:0000313|EMBL:ABL94420.1};
OS Mycobacterium sp. (strain KMS).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=189918 {ECO:0000313|EMBL:ABL94420.1};
RN [1] {ECO:0000313|EMBL:ABL94420.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KMS {ECO:0000313|EMBL:ABL94420.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D.,
RA Richardson P.;
RT "Complete sequence of chromosome of Mycobacterium sp. KMS.";
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; CP000518; ABL94420.1; -; Genomic_DNA.
DR AlphaFoldDB; A1UNL2; -.
DR STRING; 189918.Mkms_5231; -.
DR KEGG; mkm:Mkms_5231; -.
DR HOGENOM; CLU_005108_1_1_11; -.
DR OrthoDB; 7051771at2; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 20..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 564..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 595..616
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 628..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 679..696
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 708..732
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 245..371
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 772 AA; 80206 MW; 341AF30F8B84219C CRC64;
MATFLHRIGR FAFHRPWHVI AGWIVLIAVV AGVLTVNPPK ISNEMRINGT PAQEVIDQLA
ERMPQSSGGQ GSIAFAAPQG QRIDEGANLD AVLAAVDAVS RTDHVLDPRE IAAAEMAKGP
ASPTLSAAAA VTRAQVNAPA SPEAPRPLTI DGQPVPGVTV SADGAAALYQ FQFDKQTAEL
PTGAVENTID AAREAVGDRG IEVLPSASMA QMPEMVGAGE VIGLMVAAVV LIVTLGSLIA
AGLPLVTALI SVAVGVGGTF LFSHLFDMQS MTAVLALMLG LAVGIDYAMF IVNRQRRLIL
DRGLSAADAA ARAIGTAGSA VVFAGMTVVI ALVALTVVGI SLLTPMALAA AATVVVAVVA
AITLLPALLG LVGERIASPK GRHSVSTEES NHRFASAWVG AILRNRVPAA LAGLAVTGVI
ALPALSMTLG MPDGGSYNEG TPQRESYDVI AEHYGDGYNG PLVVVAEPTT AGQLTPADIA
ATYSDLRRVP GVADVTFGGV NDASDTAVFS VVPENGPTEE ATAQLVRDIR AQSGPLAELR
EVKLGVTGIT AMGIDMSDRL GKAIPVYVGI VMGLSILVLM VVFRSIAVPL KATAGFLLTV
LATFGATTAL FQWGWFQQLI GLSATGPILS MLPIMVIGVL YGLAMDYEVF LVSSMKEAHV
HGHRGDAAVA HGFTQASRVV VAAALIMMAV FAGFVFNADP MIKQMGFALA FGVLIDAFVV
RMTVVPAVMS MLGDRAWWLP KRLARVLPDL DIEGDKLNRS LEAERSEQSV PA
//
