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Database: UniProt
Entry: A1UU75_BARBK
LinkDB: A1UU75_BARBK
Original site: A1UU75_BARBK 
ID   A1UU75_BARBK            Unreviewed;       524 AA.
AC   A1UU75;
DT   06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2007, sequence version 1.
DT   27-SEP-2017, entry version 88.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:ABM44856.1};
GN   OrderedLocusNames=BARBAKC583_1279 {ECO:0000313|EMBL:ABM44856.1};
OS   Bartonella bacilliformis (strain ATCC 35685 / KC583).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=360095 {ECO:0000313|EMBL:ABM44856.1, ECO:0000313|Proteomes:UP000000643};
RN   [1] {ECO:0000313|EMBL:ABM44856.1, ECO:0000313|Proteomes:UP000000643}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35685 / KC583 {ECO:0000313|Proteomes:UP000000643};
RA   Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S.,
RA   Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R.,
RA   Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J.,
RA   Fraser-Ligget C., Seshadri R.;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP000524; ABM44856.1; -; Genomic_DNA.
DR   RefSeq; WP_011807439.1; NC_008783.1.
DR   ProteinModelPortal; A1UU75; -.
DR   STRING; 360095.BARBAKC583_1279; -.
DR   EnsemblBacteria; ABM44856; ABM44856; BARBAKC583_1279.
DR   GeneID; 4684659; -.
DR   KEGG; bbk:BARBAKC583_1279; -.
DR   PATRIC; fig|360095.6.peg.1255; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235660; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000000643; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000643};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000643}.
FT   DOMAIN      214    341       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      429    498       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     222    229       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   524 AA;  59226 MW;  41ABBF63A3E92530 CRC64;
     MVDKLSSKVS SLKRVSVDIL STEEMVNKMM DISEPVSANT SVEYPVISEE EGAAAFARVM
     AQLKTQVGIE AYTSWFGRLK LSEYNRNLVK LSVPTAFLRS WINNHYGSLL TGLWKQENSA
     ILRVEVIVRD MKRVAKNVVC RTNGNPVLPM SEKSNALPLV ENYTENSARN TQTGVFGSPL
     DSRYTFDSFV EGASNRVALA AARSVAEGHK SALRFNPLFI HASVGLGKTH LLQAIAAAAL
     KRLTSTRVIY LTAEYFMWRF ATAIRDNDAL SFKEQLRDID LLIIDDMQFL QGRSIQYEFC
     HLLNMLLDSA KQVVVAADRP PAELESLDLR VRSRLQGGVA LEIEAPDYEM RLEMLRQRLK
     IAQQDDNTIA ISDDILEYIA KTVLGSGRDI EGAFNQLLFR QSFETDLSLQ RVDELLGHLT
     RSSELRRIRI EEIQRTVARH YNVSKQDLLS NRRTRTIVKP RQVAMYLAKV LTPRSLPEIG
     RRFGGRDHTT VLHAVRKIED LVCDDQTLAK ELELLKRLIG EQTV
//
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