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Database: UniProt
Entry: A1XCJ5_SCHMD
LinkDB: A1XCJ5_SCHMD
Original site: A1XCJ5_SCHMD 
ID   A1XCJ5_SCHMD            Unreviewed;      1534 AA.
AC   A1XCJ5;
DT   06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   03-APR-2007, sequence version 2.
DT   24-JAN-2024, entry version 95.
DE   SubName: Full=Slit1 {ECO:0000313|EMBL:ABC61956.2};
OS   Schmidtea mediterranea (Freshwater planarian flatworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Seriata; Tricladida; Continenticola; Geoplanoidea;
OC   Dugesiidae; Schmidtea.
OX   NCBI_TaxID=79327 {ECO:0000313|EMBL:ABC61956.2};
RN   [1] {ECO:0000313|EMBL:ABC61956.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=17553481; DOI=10.1016/j.ydbio.2007.05.006;
RA   Cebria F., Guo T., Jopek J., Newmark P.A.;
RT   "Regeneration and maintenance of the planarian midline is regulated by a
RT   slit orthologue.";
RL   Dev. Biol. 307:394-406(2007).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; DQ336176; ABC61956.2; -; mRNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR   CDD; cd00054; EGF_CA; 6.
DR   CDD; cd00110; LamG; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   Gene3D; 2.10.25.10; Laminin; 7.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   PANTHER; PTHR45842:SF12; KEKKON 5, ISOFORM A; 1.
DR   PANTHER; PTHR45842; SYNAPTIC ADHESION-LIKE MOLECULE SALM; 1.
DR   Pfam; PF00008; EGF; 1.
DR   Pfam; PF12661; hEGF; 3.
DR   Pfam; PF02210; Laminin_G_2; 1.
DR   Pfam; PF13855; LRR_8; 4.
DR   Pfam; PF01462; LRRNT; 1.
DR   SMART; SM00041; CT; 1.
DR   SMART; SM00181; EGF; 7.
DR   SMART; SM00179; EGF_CA; 4.
DR   SMART; SM00282; LamG; 1.
DR   SMART; SM00365; LRR_SD22; 10.
DR   SMART; SM00369; LRR_TYP; 14.
DR   SMART; SM00082; LRRCT; 4.
DR   SMART; SM00013; LRRNT; 4.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF57196; EGF/Laminin; 6.
DR   SUPFAM; SSF52058; L domain-like; 3.
DR   PROSITE; PS00010; ASX_HYDROXYL; 2.
DR   PROSITE; PS01185; CTCK_1; 1.
DR   PROSITE; PS01225; CTCK_2; 1.
DR   PROSITE; PS00022; EGF_1; 7.
DR   PROSITE; PS01186; EGF_2; 7.
DR   PROSITE; PS50026; EGF_3; 7.
DR   PROSITE; PS01187; EGF_CA; 2.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 1.
DR   PROSITE; PS51450; LRR; 5.
PE   2: Evidence at transcript level;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..1534
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002640724"
FT   DOMAIN          909..944
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          946..984
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          986..1022
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1024..1062
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1064..1100
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1134..1174
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1176..1357
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
FT   DOMAIN          1390..1430
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1429..1532
FT                   /note="CTCK"
FT                   /evidence="ECO:0000259|PROSITE:PS01225"
FT   DISULFID        934..943
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        955..972
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        974..983
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1012..1021
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1052..1061
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1090..1099
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1164..1173
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1330..1357
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
FT   DISULFID        1420..1429
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   1534 AA;  174865 MW;  B5CE3AAA5BABA619 CRC64;
     MIFIFKDITF KFLLVLLSSL YCFSSTIWIN DPSDESEICP NGCQCENYSV ECKHRLFPNV
     PVILQEKTTR LNLLGNRINV IRKSDFLKLN NLKVLQLSNN RITSIEPGAF DNLVNLIKLR
     LNRNLIQYLP DDLFSKLTKL QKLDLRDNQL QCINDNIFNK LGMLKYLLLE GNKIFWISEA
     ISKLKHLKEL RIHKNKLNCN CHLAWLNWFL KQKSNIIKPG AHSVLCSTPX XLSHIPISSL
     SSYEFQCASE DKANLENMCP SDKKVCSKKC NCSHDGIVKC VGKRLSNIPQ DLPTNVVELD
     LKDNNITILQ QGYLSKYKFL KKIILTRNGM VDIEPGAFLG LTQLTSIYLN ENNLKTIRKN
     AFGGLISLMF LYLQYNDIEC LPKDTLESSK RLHLLHLSEN KLTSLKKETF KPFLNLRYLY
     LVHNPLNCDC RMSWIVDYIK DKETNTPVAA CLQPRNLQGT PLRNLQIYNF QCNKEFESKY
     ETHDEECVPK VSCPLKCTCS SDVVNCSNSG LMSLPESIFP STKTLIMSHN NLKKLTPIYS
     IHEAPNLMKL DLSFNQIETL EPDVFTRSSK LREINLNSNR LKCINNETFK NLKELEILQL
     SENAISCIVT DSFKNNLNLK YLMLNKNQFH CDCKLKWMSE WSRNHYTVLG NHRLPTCQSP
     IILKDTPITH LDDKYFLCDG NASVDHSVDS CHETNSVKTC CSIGNEECTK SKKCPSKCKC
     ESTKVDCSDL QLKEIPNEIP KDTTELYLDR NHLQSLNETS FKNLLNLKTL VLSYNGITEL
     NKNVLTPLKS LEILVLSFNK LQCIHQDAFK NLHNLKVLIL QSNDVSTIPY QAFNDLKNLN
     NIALGQNPFH CDCNIKWLNQ FFLDRFLDNG ISLCASPEKM KLKSIYHSKP TDFICSEETE
     DAYITAKCDS CMKRPCKHNG KCSLITHHNY QCDCPYPFHG KNCDKRINAC FGQPCRNGGI
     CKNIDNYGNY ECVCPVGFRG PKCTINVDDC VGNLCVNGAT CNDLNNSYSC KCQSGFRGKY
     CDIKFLYCND INPCQNSGQC QLLPNNDYKC VCSKGWEGKQ CERNTDDCKY NSCKHESQCV
     DLHNDYKCMC RPGYIGKFCE IPAWKPTVLK TLISRRDINQ SEMTYENLEN EVISESVCAY
     HECLNNGICI NGDQNKNQKS YCKCKPGYSG HLCQYLNSIY FQKNSYIEIS PPSRGFLMPR
     GNISLNFMTN SSSGLILYQG SEQTYLVVNL YQGHLRISYN LGDKVVGPEG YSMGMVNDSR
     LHALHIEIVG ENLTMYLNGR VHCTLKSKYL NSNRYMALDT GIFIGGAPHK ILQSAIMKFH
     IETDSEFIGC MESLLINRKK IDFTKYLPKS INVHPGCGKL ISTVVASDLK IPSIMQPIKQ
     ILTQTTKKKP NNVCKRPGIC KNQGVCEVLP GSKKKLRCIC KNGFVGRKCK KRKSMCHGTF
     TESHIVDPDS QGTCKSIERF QYRICTGTCS TSRMQSDVIK NFYHKPIDPS SSRCCQPTKY
     STHEIQFKCE NGRVYRRAAN LPKNCKCVAN CLND
//
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