ID A1XCJ5_SCHMD Unreviewed; 1534 AA.
AC A1XCJ5;
DT 06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 2.
DT 24-JAN-2024, entry version 95.
DE SubName: Full=Slit1 {ECO:0000313|EMBL:ABC61956.2};
OS Schmidtea mediterranea (Freshwater planarian flatworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Seriata; Tricladida; Continenticola; Geoplanoidea;
OC Dugesiidae; Schmidtea.
OX NCBI_TaxID=79327 {ECO:0000313|EMBL:ABC61956.2};
RN [1] {ECO:0000313|EMBL:ABC61956.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17553481; DOI=10.1016/j.ydbio.2007.05.006;
RA Cebria F., Guo T., Jopek J., Newmark P.A.;
RT "Regeneration and maintenance of the planarian midline is regulated by a
RT slit orthologue.";
RL Dev. Biol. 307:394-406(2007).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; DQ336176; ABC61956.2; -; mRNA.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 6.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45842:SF12; KEKKON 5, ISOFORM A; 1.
DR PANTHER; PTHR45842; SYNAPTIC ADHESION-LIKE MOLECULE SALM; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF12661; hEGF; 3.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01462; LRRNT; 1.
DR SMART; SM00041; CT; 1.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00365; LRR_SD22; 10.
DR SMART; SM00369; LRR_TYP; 14.
DR SMART; SM00082; LRRCT; 4.
DR SMART; SM00013; LRRNT; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 6.
DR SUPFAM; SSF52058; L domain-like; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS00022; EGF_1; 7.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 7.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
DR PROSITE; PS51450; LRR; 5.
PE 2: Evidence at transcript level;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1534
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002640724"
FT DOMAIN 909..944
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 946..984
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 986..1022
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1024..1062
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1064..1100
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1134..1174
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1176..1357
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1390..1430
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1429..1532
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT DISULFID 934..943
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 955..972
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 974..983
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1012..1021
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1052..1061
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1090..1099
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1164..1173
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1330..1357
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
FT DISULFID 1420..1429
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1534 AA; 174865 MW; B5CE3AAA5BABA619 CRC64;
MIFIFKDITF KFLLVLLSSL YCFSSTIWIN DPSDESEICP NGCQCENYSV ECKHRLFPNV
PVILQEKTTR LNLLGNRINV IRKSDFLKLN NLKVLQLSNN RITSIEPGAF DNLVNLIKLR
LNRNLIQYLP DDLFSKLTKL QKLDLRDNQL QCINDNIFNK LGMLKYLLLE GNKIFWISEA
ISKLKHLKEL RIHKNKLNCN CHLAWLNWFL KQKSNIIKPG AHSVLCSTPX XLSHIPISSL
SSYEFQCASE DKANLENMCP SDKKVCSKKC NCSHDGIVKC VGKRLSNIPQ DLPTNVVELD
LKDNNITILQ QGYLSKYKFL KKIILTRNGM VDIEPGAFLG LTQLTSIYLN ENNLKTIRKN
AFGGLISLMF LYLQYNDIEC LPKDTLESSK RLHLLHLSEN KLTSLKKETF KPFLNLRYLY
LVHNPLNCDC RMSWIVDYIK DKETNTPVAA CLQPRNLQGT PLRNLQIYNF QCNKEFESKY
ETHDEECVPK VSCPLKCTCS SDVVNCSNSG LMSLPESIFP STKTLIMSHN NLKKLTPIYS
IHEAPNLMKL DLSFNQIETL EPDVFTRSSK LREINLNSNR LKCINNETFK NLKELEILQL
SENAISCIVT DSFKNNLNLK YLMLNKNQFH CDCKLKWMSE WSRNHYTVLG NHRLPTCQSP
IILKDTPITH LDDKYFLCDG NASVDHSVDS CHETNSVKTC CSIGNEECTK SKKCPSKCKC
ESTKVDCSDL QLKEIPNEIP KDTTELYLDR NHLQSLNETS FKNLLNLKTL VLSYNGITEL
NKNVLTPLKS LEILVLSFNK LQCIHQDAFK NLHNLKVLIL QSNDVSTIPY QAFNDLKNLN
NIALGQNPFH CDCNIKWLNQ FFLDRFLDNG ISLCASPEKM KLKSIYHSKP TDFICSEETE
DAYITAKCDS CMKRPCKHNG KCSLITHHNY QCDCPYPFHG KNCDKRINAC FGQPCRNGGI
CKNIDNYGNY ECVCPVGFRG PKCTINVDDC VGNLCVNGAT CNDLNNSYSC KCQSGFRGKY
CDIKFLYCND INPCQNSGQC QLLPNNDYKC VCSKGWEGKQ CERNTDDCKY NSCKHESQCV
DLHNDYKCMC RPGYIGKFCE IPAWKPTVLK TLISRRDINQ SEMTYENLEN EVISESVCAY
HECLNNGICI NGDQNKNQKS YCKCKPGYSG HLCQYLNSIY FQKNSYIEIS PPSRGFLMPR
GNISLNFMTN SSSGLILYQG SEQTYLVVNL YQGHLRISYN LGDKVVGPEG YSMGMVNDSR
LHALHIEIVG ENLTMYLNGR VHCTLKSKYL NSNRYMALDT GIFIGGAPHK ILQSAIMKFH
IETDSEFIGC MESLLINRKK IDFTKYLPKS INVHPGCGKL ISTVVASDLK IPSIMQPIKQ
ILTQTTKKKP NNVCKRPGIC KNQGVCEVLP GSKKKLRCIC KNGFVGRKCK KRKSMCHGTF
TESHIVDPDS QGTCKSIERF QYRICTGTCS TSRMQSDVIK NFYHKPIDPS SSRCCQPTKY
STHEIQFKCE NGRVYRRAAN LPKNCKCVAN CLND
//