ID A1Y2D3_LEIIN Unreviewed; 273 AA.
AC A1Y2D3;
DT 06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Prostaglandin f2-alpha synthase {ECO:0000313|EMBL:ABI17865.1};
DE Flags: Fragment;
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:ABI17865.1};
RN [1] {ECO:0000313|EMBL:ABI17865.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bman {ECO:0000313|EMBL:ABI17866.1}, LIU
RC {ECO:0000313|EMBL:ABL10356.1}, and OG-VL
RC {ECO:0000313|EMBL:ABI17865.1};
RX PubMed=17142569; DOI=10.1128/EC.00282-06;
RA Waki K., Dutta S., Ray D., Kolli B.K., Akman L., Kawazu S., Lin C.P.,
RA Chang K.P.;
RT "Transmembrane molecules for phylogenetic analyses of pathogenic protists:
RT Leishmania-specific informative sites in hydrophilic loops of
RT trans- endoplasmic reticulum N-acetylglucosamine-1-phosphate transferase.";
RL Eukaryot. Cell 6:198-210(2007).
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DR EMBL; DQ834276; ABI17865.1; -; Genomic_DNA.
DR EMBL; DQ834277; ABI17866.1; -; Genomic_DNA.
DR EMBL; DQ981498; ABL10356.1; -; Genomic_DNA.
DR AlphaFoldDB; A1Y2D3; -.
DR VEuPathDB; TriTrypDB:LINF_310029700; -.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 4: Predicted;
FT DOMAIN 14..264
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 48
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 106
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 73
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABI17865.1"
FT NON_TER 273
FT /evidence="ECO:0000313|EMBL:ABI17865.1"
SQ SEQUENCE 273 AA; 30588 MW; 31B0143CA163BB04 CRC64;
PMVTLSNGVQ MPQLGLGVWQ SPAGEVTANA VKWALCAGYR HIDTAAIYKN EESVGAGLRA
SGVPREDVFI TTKLWNTEQG YESTLAAFEE SRQKLGVDYI DLYLIHWPRG KDIVSKEGKK
YLDSWRAFEQ LYKDKKVRAI GVSNFHIHHL EDVLAMCTVT PMVNQVELHP LNNQAELRAF
CDAKQIKVEA WSPLGQGKLL SNPILAAIGA KYNKTAAQVI LRWNIQKNLI TIPKSVHKER
IEENADVFNF ELGAEDVMRI DALNTNSRYG PDP
//