ID A1Y3V0_LISMN Unreviewed; 737 AA.
AC A1Y3V0;
DT 06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Internalin A {ECO:0000313|EMBL:ABI27303.1};
DE Flags: Fragment;
GN Name=inlA {ECO:0000313|EMBL:ABI27303.1};
GN ORFNames=LMOf2365_0471 {ECO:0000313|EMBL:ABI27303.1};
OS Listeria monocytogenes.
OC Bacteria; Bacillota; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=1639 {ECO:0000313|EMBL:ABI27303.1};
RN [1] {ECO:0000313|EMBL:ABI27303.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NRRL B-33462 {ECO:0000313|EMBL:ABI27303.1}, and NRRL B-33464
RC {ECO:0000313|EMBL:ABI27305.1};
RX PubMed=17085705; DOI=10.1128/AEM.01453-06;
RA Ducey T.F., Page B., Usgaard T., Borucki M.K., Pupedis K., Ward T.J.;
RT "A single-nucleotide-polymorphism-based multilocus genotyping assay for
RT subtyping lineage I isolates of Listeria monocytogenes.";
RL Appl. Environ. Microbiol. 73:133-147(2007).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the internalin family.
CC {ECO:0000256|ARBA:ARBA00009432}.
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DR EMBL; DQ843845; ABI27303.1; -; Genomic_DNA.
DR EMBL; DQ843847; ABI27305.1; -; Genomic_DNA.
DR AlphaFoldDB; A1Y3V0; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.1220; -; 1.
DR Gene3D; 2.60.40.4270; Listeria-Bacteroides repeat domain; 3.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR014755; Cu-Rt/internalin_Ig-like.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR012569; Inl_IR.
DR InterPro; IPR047600; InlA.
DR InterPro; IPR013378; InlB-like_B-rpt.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR042229; Listeria/Bacterioides_rpt_sf.
DR InterPro; IPR019931; LPXTG_anchor.
DR InterPro; IPR032675; LRR_dom_sf.
DR NCBIfam; NF033189; internalin_A; 1.
DR NCBIfam; TIGR02543; List_Bact_rpt; 3.
DR NCBIfam; TIGR01167; LPXTG_anchor; 1.
DR PANTHER; PTHR46652; LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46652:SF3; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9 ISOFORM X1; 1.
DR Pfam; PF09479; Flg_new; 3.
DR Pfam; PF00746; Gram_pos_anchor; 1.
DR Pfam; PF12799; LRR_4; 6.
DR Pfam; PF08191; LRR_adjacent; 1.
DR SMART; SM00365; LRR_SD22; 15.
DR SMART; SM00369; LRR_TYP; 11.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
DR PROSITE; PS51450; LRR; 13.
PE 3: Inferred from homology;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 713..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 704..737
FT /note="Gram-positive cocci surface proteins LPxTG"
FT /evidence="ECO:0000259|PROSITE:PS50847"
FT REGION 643..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABI27303.1"
SQ SEQUENCE 737 AA; 79698 MW; 6D3A1E88432FA765 CRC64;
TNVTDTVSQT DLDQVTTLQA DRLGIKSIDG LEYLNNLTQI NFSNNQLTDI TPLKDLTKLV
DILMNNNQIA DITPLANLTN LTGLTLFNNQ ITDIDPLKNL TNLNRLELSS NTISDISALS
GLTNLQQLSF GNQVTDLKPL ANLTTLERLD ISSNKVSDIS VLAKLTNLES LIATNNQISD
ITPLGILTNL DELSLNGNQL KDIGTLASLT NLTDLDLANN QISNLAPLSG LTKLTELKLG
ANQISNISPL AGLTALTNLE LNENQLEDIS PISNLKNLTY LTLYFNNISD ISPVSSLTKL
QRLFFYNNKV SDVSSLANLT NINWLSAGHN QISDLTPLAN LTRITQLGLN DQEWTNPPVN
YKVNVSIPNT VKNVTGALIA PATISDGGSY AEPDITWNLP SYTNEVSYTF NQSVTIGKGT
TTFSGTVTQP LKAIFNAKFH VDGKETTKEV EAGNLLTEPA KPVKEGYTFV GWFDAQTGGT
KWNFSTDKMP TNDIDLYAQF SINSYTATFD NDGVTTSQTV DYQGLLQEPT APTKEGYTFK
GWYDAKTGGD KWDFATSKMP AKNITLYAQY SANSYTATFD VDGKTTTQAV DYQGLLKEPK
TPTKAGYTFK GWYDEKTDGK KWDFATDKMP ANDITLYAQF TKNSVAPPTT GGNTPPTTNN
GGNTTPPSAN IPGSNTSNTS TGNSASTTST MNAYDPYNSK EASLPTTGDS DNALYLLIGL
LAVGTAVALT KKARASK
//
