ID A1Y9B0_MOUSE Unreviewed; 279 AA.
AC A1Y9B0;
DT 06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=Tumor necrosis factor ligand superfamily member 6 {ECO:0000256|ARBA:ARBA00018020};
DE AltName: Full=CD95 ligand {ECO:0000256|ARBA:ARBA00030760};
DE AltName: Full=Fas antigen ligand {ECO:0000256|ARBA:ARBA00030913};
GN Name=Fasl {ECO:0000313|MGI:MGI:99255};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:ABI24111.1};
RN [1] {ECO:0000313|EMBL:ABI24111.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SEG/Pas {ECO:0000313|EMBL:ABI24111.1};
RX PubMed=17545588; DOI=10.1158/0008-5472.CAN-06-4006;
RA Villa-Morales M., Santos J., Perez-Gomez E., Quintanilla M.,
RA Fernandez-Piqueras J.;
RT "A role for the Fas/FasL system in modulating genetic susceptibility to T-
RT cell lymphoblastic lymphomas.";
RL Cancer Res. 67:5107-5116(2007).
CC -!- FUNCTION: Cytoplasmic form induces gene transcription inhibition.
CC {ECO:0000256|ARBA:ARBA00003149}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle lumen
CC {ECO:0000256|ARBA:ARBA00004321}. Lysosome lumen
CC {ECO:0000256|ARBA:ARBA00004227}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR EMBL; DQ846747; ABI24111.1; -; mRNA.
DR AlphaFoldDB; A1Y9B0; -.
DR SMR; A1Y9B0; -.
DR AGR; MGI:99255; -.
DR MGI; MGI:99255; Fasl.
DR ChiTaRS; Fasl; mouse.
DR GO; GO:0060205; C:cytoplasmic vesicle lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR028326; FASL.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471; TUMOR NECROSIS FACTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11471:SF33; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6; 1.
DR Pfam; PF00229; TNF; 1.
DR PRINTS; PR01681; FASLIGAND.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 2: Evidence at transcript level;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT TRANSMEM 79..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 144..279
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
FT REGION 20..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..68
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 279 AA; 31400 MW; 106DA3DC6C48151B CRC64;
MQQPMNYPCP QIFWVDSSAT SSWTPPGSVF PCPSSGPRGP DQRRPPPPPP PVSPLPPPSQ
PLPLPPLTPL KKKDHNTNLW LPVVFFMVLV ALVGMGLGMY QLFHLQKELA ELREFTNQSL
KVSSFEKQIA NPSTPSEKKE LRSVAHLTGN PHSRSIPLEW EDTYGTALIS GVKYKKGSLV
INEAGLYFVY SKVYFRGQSC NNQPLNHKVY MRNSKYPGDL VLMEEKRLNY CTTGQIWAHS
SYLGAVFNLT SADHLYVNIS QLSLINFEES KTFFGLYKL
//
