ID   A1YUW8_SOLTU            Unreviewed;       848 AA.
AC   A1YUW8;
DT   06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2007, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   SubName: Full=Tm-2 ToMV resistance protein {ECO:0000313|EMBL:ABM05492.1};
OS   Solanum tuberosum (Potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4113 {ECO:0000313|EMBL:ABM05492.1};
RN   [1] {ECO:0000313|EMBL:ABM05492.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Leaf {ECO:0000313|EMBL:ABM05492.1};
RA   Wu X., Hu Z., Chen G.;
RT   "Cloning and characterization of LeTm-2-homology gene StTm-2 from potato.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000256|ARBA:ARBA00008894}.
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DR   EMBL; EF137705; ABM05492.1; -; mRNA.
DR   AlphaFoldDB; A1YUW8; -.
DR   ExpressionAtlas; A1YUW8; baseline.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR   CDD; cd14798; RX-CC_like; 1.
DR   Gene3D; 1.20.5.4130; -; 1.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038005; RX-like_CC.
DR   InterPro; IPR041118; Rx_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR   PANTHER; PTHR23155:SF1227; TOMV SUSCEPTIBLE PROTEIN TM-2; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF18052; Rx_N; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   2: Evidence at transcript level;
KW   Plant defense {ECO:0000256|ARBA:ARBA00022821}.
FT   DOMAIN          179..313
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
SQ   SEQUENCE   848 AA;  96908 MW;  CF34B437628127B0 CRC64;
     MAEILLTAVI NKSIEIAGNL LFQEGSRLNF LKEDIDWLQR VLRHIRSYVD DAKAKEVGGD
     SKVKNLLKDI QELAGDVEDL LDDFLPKIQQ SNKFICFLKT ACIPCANEFA MEIEKIRRRV
     ADIDRLRTTF NITDTSNNNN DCIPMEQRRK FLRADETEVI GLDDAFNTLQ AKLLDQDLPY
     GVVSIVGMPG LGKTTLAKKL YRHVRHQFES SGLVYVSQQP RAGEILHDIA KQVGLPEEER
     KENLENNLRS LLKIKRYVIL LDDIWDVEIW DHLKLVLPER DSKIGSRIII TSRNSNVGRY
     IGGDFSIHVL QPLDSENSFE LFTKKIFTFD NNNNWDSASP DWVDIGRSIV GRCGGIPLAI
     VVTAGILRAR ERTERAWNRV LDSMGHKVQD GCAKVLALSY NDLPIALRPC FLYFGLYPED
     HEIHAFDLTN MWIAEKLIVV NSGNMREAED LVEDVLNDLV SRNLIQVAKW KYNGRISSCR
     IHDMLHSLCV DLAEESNFFH TEYNAFGDLR NVARVRRITF YSDNVMNEFF RSNPNPKKLL
     ALFCFTKDRC IFAQLAHLDF KLLQVLVVVM SQDGYGGFTM GNKFGKMSCL RYLRLEGVIR
     GKLLNNIVKL KCLETIGIGV GDIELPCSVW DFKQLRHVHC REELKGFFSN KPKHVAHDNL
     QTLMWMDDNF FEARLLHQLI NLRKLGISSA SNSTIKILSG LSPVPKTLEV LKLKFCNESS
     EQINLSSYLN IVKLHLNAAM RLTCEAFPPN LVKLTLVYLT VDDHVVAELK KLPKLRILKM
     VGCEHKKEEM DLSGDGFPQL EVLHIQNPLW LPEITCTDDV SMPKLKKLLL TGVYSQIRLS
     ERLVKLRV
//