ID A2A517_MOUSE Unreviewed; 460 AA.
AC A2A517;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 126.
DE SubName: Full=Cytohesin 1 {ECO:0000313|Ensembl:ENSMUSP00000097756.5};
DE Flags: Fragment;
GN Name=Cyth1 {ECO:0000313|Ensembl:ENSMUSP00000097756.5,
GN ECO:0000313|MGI:MGI:1334257};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000097756.5, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000097756.5, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000097756.5,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000097756.5}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000097756.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A2A517; -.
DR SMR; A2A517; -.
DR SwissPalm; A2A517; -.
DR MaxQB; A2A517; -.
DR PeptideAtlas; A2A517; -.
DR ProteomicsDB; 341095; -.
DR Antibodypedia; 19745; 287 antibodies from 33 providers.
DR Ensembl; ENSMUST00000100181.11; ENSMUSP00000097756.5; ENSMUSG00000017132.18.
DR AGR; MGI:1334257; -.
DR MGI; MGI:1334257; Cyth1.
DR VEuPathDB; HostDB:ENSMUSG00000017132; -.
DR GeneTree; ENSGT00940000157519; -.
DR PhylomeDB; A2A517; -.
DR ChiTaRS; Cyth1; mouse.
DR Proteomes; UP000000589; Chromosome 11.
DR Bgee; ENSMUSG00000017132; Expressed in vestibular membrane of cochlear duct and 233 other cell types or tissues.
DR ExpressionAtlas; A2A517; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR GO; GO:0030155; P:regulation of cell adhesion; IEA:Ensembl.
DR CDD; cd01252; PH_GRP1-like; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF340; CYTOHESIN-1; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:A2A517,
KW ECO:0007829|MaxQB:A2A517};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 69..256
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 274..390
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000097756.5"
SQ SEQUENCE 460 AA; 52492 MW; 05C641B372A3DADD CRC64;
EVSGGRGPEP VASTMEDDDS YVPSDLTAEE RQELENIRRR KQELLADIQR LKEEIAEVAN
EIESLGSTEE RKNMQRNKQV AMGRKKFNMD PKKGIQFLIE NGLLKNTCED IAQFLYKGEG
LNKTAIGDYL GERDEFSIQV LHAFVELHEF TDLNLVQALR QFLWSFRLPG EAQKIDRMME
AFAQRYCQCN TGVFQSTDTC YVLSFAIIML NTSLHNPNVK DKPTVERFIA MNRGINDGGD
LPEELLRNLY ESIKNEPFKI PEDDGNDLTH TFFNPDREGW LLKLGGRVKT WKRRWFILTD
NCLYYFEYTT DKEPRGIIPL ENLSIREVED SKKPNCFELY IPDNKDQVIK ACKTEADGRV
VEGNHTVYRI SAPTPEEKED WIKCIKNTSP RGHMEASWKL HLPASPAAVV AIAVVTASTL
VLLLIPGDSE CQEWPSGNEP GPAFTMPLTH LPEDTTRGRN
//
