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Entry: A2A5F7_MOUSE
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ID   A2A5F7_MOUSE            Unreviewed;      1018 AA.
AC   A2A5F7;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   22-NOV-2017, entry version 97.
DE   SubName: Full=potassium Voltage-gated channel, subfamily H (Eag-related), member 4 {ECO:0000313|EMBL:AAI50991.1, ECO:0000313|Ensembl:ENSMUSP00000102984};
GN   Name=Kcnh4 {ECO:0000313|EMBL:AAI50991.1,
GN   ECO:0000313|Ensembl:ENSMUSP00000102984, ECO:0000313|MGI:MGI:2156184};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000102984, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|EMBL:AAI50991.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000313|EMBL:AAI50991.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
RA   Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
RA   Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
RA   Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
RA   Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
RA   Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
RA   Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
RA   Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
RA   Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
RA   Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
RA   Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
RA   Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
RA   Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
RA   Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
RA   Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
RA   Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
RA   Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
RA   Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
RA   Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000102984, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000102984,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000102984}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000102984};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AL591466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL591469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC150990; AAI50991.1; -; mRNA.
DR   EMBL; BC150994; AAI50995.1; -; mRNA.
DR   RefSeq; NP_001074663.1; NM_001081194.2.
DR   UniGene; Mm.297539; -.
DR   STRING; 10090.ENSMUSP00000102984; -.
DR   DNASU; 380728; -.
DR   Ensembl; ENSMUST00000107361; ENSMUSP00000102984; ENSMUSG00000035355.
DR   Ensembl; ENSMUST00000107363; ENSMUSP00000102986; ENSMUSG00000035355.
DR   GeneID; 380728; -.
DR   KEGG; mmu:380728; -.
DR   UCSC; uc007lmf.2; mouse.
DR   CTD; 23415; -.
DR   MGI; MGI:2156184; Kcnh4.
DR   eggNOG; KOG0498; Eukaryota.
DR   eggNOG; ENOG410XPSE; LUCA.
DR   GeneTree; ENSGT00900000140833; -.
DR   HOGENOM; HOG000230794; -.
DR   HOVERGEN; HBG052232; -.
DR   KO; K04907; -.
DR   OMA; VPKAVWD; -.
DR   OrthoDB; EOG091G0OXR; -.
DR   TreeFam; TF313130; -.
DR   Reactome; R-MMU-1296072; Voltage gated Potassium channels.
DR   Proteomes; UP000000589; Chromosome 11.
DR   Bgee; ENSMUSG00000035355; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR003950; K_chnl_volt-dep_ELK.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   PRINTS; PR01465; ELKCHANNEL.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00086; PAC; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Ion channel {ECO:0000256|SAAS:SAAS00904115};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00903208};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00904256};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00903350};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00903851}.
FT   TRANSMEM    228    248       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    268    288       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    323    345       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    357    383       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    425    447       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    454    478       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       14     90       PAS. {ECO:0000259|PROSITE:PS50112}.
FT   DOMAIN       93    145       PAC. {ECO:0000259|PROSITE:PS50113}.
FT   DOMAIN      556    620       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   COILED      874    908       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1018 AA;  111481 MW;  C4FF6748C0DAF45C CRC64;
     MPVMKGLLAP QNTFLDTIAT RFDGTHSNFL LANAQGPRGF PIVYCSDGFC ELTGYGRTEV
     MQKTCSCRFL YGPETSEPAL QRLQKALEGH QEHRTEICFY RKDGSAFWCL LDMMPIKNEM
     GEVVLFLFSF KDISQSGGPG LGSPGIHGDN NHENSLGRRG TSSRLRSTKR QNRTVLHRLT
     GHFGRRGQSS VKANSNLFEP KPSVPEYKVA SVGGSRCLLL HYSIPKAVWD GLILLATFYV
     AVTVPYNVCF AGDDDTPITS RHTLVSDIAV EMLFILDIIL NFRTTYVSQS GQVISAPRSI
     GLHYLATWFF VDLIAALPFD LLYVFNITVT SLVHLLKTVR LLRLLRLLQK LERYSQCSAV
     VLTLLMSVFA LLAHWMACVW YVIGRREMEA NDPLLWDIGW LHELGKRLEE PYVNGSAGGP
     SRRSAYIAAL YFTLSSLTSV GFGNVCANTD AEKIFSICTM LIGALMHAVV FGNVTAIIQR
     MYSRRSLYHS RMKDLKDFIR VHRLPRPLKQ RMLEYFQTTW AVNSGIDANE LLRDFPDELR
     ADIAMHLNRE ILQLPLFGAA SRGCLRALSL HIKTSFCAPG EYLLRRGDAL QAHYYVCSGS
     LEVLRDNMVL AILGKGDLIG ADIPELGQEP GSGAGPSCVL KTSADVKALT YCGLQQLSSR
     GLAEVLRLYP EYAAAFRAGL PRDLTFNLRQ GSENNGLGRF SRSPRLSQAR SDTLGSSSDK
     TLPSITETEG GTEPGAGSKP RRPHLLPNLS PARPRGSLVS LLGEELPPFS ALVSSPSLSP
     TPSPALAGRG QSPSPHGPPR GSAAWKPPQL LIPPLGTFGP PDLSPRIVDG IEDSSNTAEA
     PTFRFSKRPE PTRTRSQAPP SGPRLSRELA TEAAEEVKEK VCRLNQEISR LNQEVSQLSR
     ELRQVMGLLQ ARLGPPSHTA GPAWLPDLPC PHQRLPCISP HMSGPPPGLQ NTTLAVVHCP
     ASVGTVEIGA TPSELRPSTI PPYPSEPDPL GPSPAPEAPP LTPSLLKHSF QSGSDTFH
//
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