ID A2A5J9_MOUSE Unreviewed; 219 AA.
AC A2A5J9;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 9.
DT 27-MAR-2024, entry version 106.
DE SubName: Full=Cathepsin A {ECO:0000313|Ensembl:ENSMUSP00000123413.3};
DE Flags: Fragment;
GN Name=Ctsa {ECO:0000313|Ensembl:ENSMUSP00000123413.3,
GN ECO:0000313|MGI:MGI:97748};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000123413.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000123413.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123413.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000123413.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123413.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S10 family.
CC {ECO:0000256|ARBA:ARBA00009431}.
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DR AlphaFoldDB; A2A5J9; -.
DR SMR; A2A5J9; -.
DR ESTHER; mouse-Ppgb; Carboxypeptidase_S10.
DR jPOST; A2A5J9; -.
DR PeptideAtlas; A2A5J9; -.
DR ProteomicsDB; 324121; -.
DR Antibodypedia; 27832; 521 antibodies from 36 providers.
DR Ensembl; ENSMUST00000143780.9; ENSMUSP00000123413.3; ENSMUSG00000017760.17.
DR AGR; MGI:97748; -.
DR MGI; MGI:97748; Ctsa.
DR VEuPathDB; HostDB:ENSMUSG00000017760; -.
DR GeneTree; ENSGT00880000138014; -.
DR HOGENOM; CLU_008523_0_0_1; -.
DR ChiTaRS; Ctsa; mouse.
DR Proteomes; UP000000589; Chromosome 2.
DR Bgee; ENSMUSG00000017760; Expressed in stroma of bone marrow and 272 other cell types or tissues.
DR ExpressionAtlas; A2A5J9; baseline and differential.
DR GO; GO:0004185; F:serine-type carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001563; Peptidase_S10.
DR PANTHER; PTHR11802:SF497; LYSOSOMAL PROTECTIVE PROTEIN; 1.
DR PANTHER; PTHR11802; SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE; 1.
DR Pfam; PF00450; Peptidase_S10; 2.
DR PRINTS; PR00724; CRBOXYPTASEC.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:A2A5J9,
KW ECO:0007829|MaxQB:A2A5J9};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 36..219
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016468342"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000123413.3"
FT NON_TER 219
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000123413.3"
SQ SEQUENCE 219 AA; 24263 MW; 19FBC34D16D7D79F CRC64;
APPGEQGRKE AEMPGTALSP LLLLLLLSWA SRNEAAPDQD EIDCLPGLAK QPSFRQYSGY
LRASDSKHFH YWFVESQNDP KNSPVVLWLN GGPGCSSLDG LLTEHGPFLI QPDGVTLEYN
PYAWNLIANV LYIESPAGVG FSYSDDKMYV TNDTEGLAVG NGLASYEQND NSLVYFAYYH
GLLGNRLWTS LQTHCCAQNK CNFYDNKDPE CVNNLLEVS
//
