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Database: UniProt
Entry: A2A5Y6_MOUSE
LinkDB: A2A5Y6_MOUSE
Original site: A2A5Y6_MOUSE 
ID   A2A5Y6_MOUSE            Unreviewed;       749 AA.
AC   A2A5Y6;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   26-NOV-2014, entry version 66.
DE   RecName: Full=Microtubule-associated protein {ECO:0000256|RuleBase:RU000686};
GN   Name=Mapt {ECO:0000313|Ensembl:ENSMUSP00000102602,
GN   ECO:0000313|MGI:MGI:97180};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000102602, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000213|PubMed:15345747}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=15345747; DOI=10.1074/mcp.M400085-MCP200;
RA   Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
RT   "Phosphoproteomic analysis of the developing mouse brain.";
RL   Mol. Cell. Proteomics 3:1093-1101(2004).
RN   [2] {ECO:0000213|PubMed:16452087}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=16452087; DOI=10.1074/mcp.T500041-MCP200;
RA   Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,
RA   Burlingame A.L.;
RT   "Comprehensive identification of phosphorylation sites in postsynaptic
RT   density preparations.";
RL   Mol. Cell. Proteomics 5:914-922(2006).
RN   [3] {ECO:0000213|PubMed:17242355}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA   Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT   "Large-scale phosphorylation analysis of mouse liver.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000102602, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000102602,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [5] {ECO:0000313|Ensembl:ENSMUSP00000102602}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000102602};
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|RuleBase:RU000686}.
CC   -!- SIMILARITY: Contains 4 Tau/MAP repeats.
CC       {ECO:0000256|RuleBase:RU000686}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000102602}.
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DR   EMBL; AL593843; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL596383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   MaxQB; A2A5Y6; -.
DR   PRIDE; A2A5Y6; -.
DR   Ensembl; ENSMUST00000106989; ENSMUSP00000102602; ENSMUSG00000018411.
DR   MGI; MGI:97180; Mapt.
DR   GeneTree; ENSGT00530000063491; -.
DR   HOGENOM; HOG000231029; -.
DR   HOVERGEN; HBG000991; -.
DR   OMA; MKVKGAD; -.
DR   PhylomeDB; A2A5Y6; -.
DR   ChiTaRS; Mapt; mouse.
DR   NextBio; 35542628; -.
DR   ExpressionAtlas; A2A5Y6; baseline and differential.
DR   GO; GO:0030424; C:axon; IDA:MGI.
DR   GO; GO:0005930; C:axoneme; IDA:MGI.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IDA:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0014069; C:postsynaptic density; IDA:MGI.
DR   GO; GO:0008017; F:microtubule binding; IDA:MGI.
DR   GO; GO:0007628; P:adult walking behavior; IGI:MGI.
DR   GO; GO:0008088; P:axon cargo transport; IGI:MGI.
DR   GO; GO:0048675; P:axon extension; IMP:MGI.
DR   GO; GO:0007409; P:axonogenesis; IGI:MGI.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IMP:MGI.
DR   GO; GO:0047497; P:mitochondrion transport along microtubule; IMP:MGI.
DR   GO; GO:0032387; P:negative regulation of intracellular transport; IMP:MGI.
DR   GO; GO:0001764; P:neuron migration; IMP:MGI.
DR   GO; GO:0045773; P:positive regulation of axon extension; IMP:MGI.
DR   GO; GO:0060632; P:regulation of microtubule-based movement; IDA:MGI.
DR   InterPro; IPR027324; MAP2/MAP4/Tau.
DR   InterPro; IPR001084; MAP_tubulin-bd_rpt.
DR   InterPro; IPR002955; Tau.
DR   PANTHER; PTHR11501; PTHR11501; 1.
DR   Pfam; PF00418; Tubulin-binding; 4.
DR   PRINTS; PR01261; TAUPROTEIN.
DR   PROSITE; PS00229; TAU_MAP_1; 4.
DR   PROSITE; PS51491; TAU_MAP_2; 4.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Cytoplasm {ECO:0000256|RuleBase:RU000686};
KW   Cytoskeleton {ECO:0000256|RuleBase:RU000686};
KW   Microtubule {ECO:0000256|RuleBase:RU000686};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Repeat {ECO:0000256|RuleBase:RU003534}.
SQ   SEQUENCE   749 AA;  78086 MW;  FAE2174381807E38 CRC64;
     MADPRQEFDT MEDHAGDYTL LQDQEGDMDH GLKESPPQPP ADDGAEEPGS ETSDAKSTPT
     AEDVTAPLVD ERAPDKQAAA QPHTEIPEGI TAEEAGIGDT PNQEDQAAGH VTQEPEKVEI
     FSQSLLVEPG RREGQAPDLG TSDWTRQQVS SMSGAPLLPQ GLREATCQPS GTRPEDIEKS
     HPASELLRRG PPQKEGWGQD RLGSEEEVDE DLTVDESSQD SPPSQASLTP GRAAPQAGSG
     SVCGETASVP GLPTEGSVPL PADFFSKVSA ETQASQPEGP GTGPMEEGHE AAPEFTFHVE
     IKASTPKEQD LEGATVVGVP GEEQKAQTQG PSVGKGTKEA SLQEPPGKQP AAGLPGRPVS
     RVPQLKARVA SKDRTGNDEK KAKTSTPSCA KAPSHRPCLS PTRPTLGSSD PLIKPSSPAV
     CPEPATSPKH VSSVTPRNGS PGTKQMKLKG ADGKTGAKIA TPRGAASPAQ KGTSNATRIP
     AKTTPSPKTP PGSGEPPKSG ERSGYSSPGS PGTPGSRSRT PSLPTPPTRE PKKVAVVRTP
     PKSPSASKSR LQTAPVPMPD LKNVRSKIGS TENLKHQPGG GKVQIINKKL DLSNVQSKCG
     SKDNIKHVPG GGSVQIVYKP VDLSKVTSKC GSLGNIHHKP GGGQVEVKSE KLDFKDRVQS
     KIGSLDNITH VPGGGNKKIE THKLTFRENA KAKTDHGAEI VYKSPVVSGD TSPRHLSNVS
     STGSIDMVDS PQLATLADEV SASLAKQGL
//
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