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Database: UniProt
Entry: A2AI57_MOUSE
LinkDB: A2AI57_MOUSE
Original site: A2AI57_MOUSE 
ID   A2AI57_MOUSE            Unreviewed;      1862 AA.
AC   A2AI57;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   22-NOV-2017, entry version 88.
DE   SubName: Full=Transient receptor potential cation channel subfamily M member 7 {ECO:0000313|Ensembl:ENSMUSP00000028843};
GN   Name=Trpm7 {ECO:0000313|Ensembl:ENSMUSP00000028843,
GN   ECO:0000313|MGI:MGI:1929996};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000028843, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000213|PubMed:19144319}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA   Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA   Thibault P.;
RT   "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL   Immunity 30:143-154(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000028843, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000028843,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0000213|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000028843}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000028843};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000028843}.
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DR   EMBL; AL732330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001157797.1; NM_001164325.1.
DR   UniGene; Mm.244705; -.
DR   ProteinModelPortal; A2AI57; -.
DR   SMR; A2AI57; -.
DR   MaxQB; A2AI57; -.
DR   PaxDb; A2AI57; -.
DR   PeptideAtlas; A2AI57; -.
DR   PRIDE; A2AI57; -.
DR   Ensembl; ENSMUST00000028843; ENSMUSP00000028843; ENSMUSG00000027365.
DR   GeneID; 58800; -.
DR   UCSC; uc008meg.2; mouse.
DR   CTD; 54822; -.
DR   MGI; MGI:1929996; Trpm7.
DR   eggNOG; KOG3614; Eukaryota.
DR   eggNOG; ENOG410XR5B; LUCA.
DR   GeneTree; ENSGT00760000119127; -.
DR   HOGENOM; HOG000230920; -.
DR   HOVERGEN; HBG055663; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   Bgee; ENSMUSG00000027365; -.
DR   ExpressionAtlas; A2AI57; baseline and differential.
DR   Genevisible; A2AI57; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0001726; C:ruffle; IEA:Ensembl.
DR   GO; GO:0003779; F:actin binding; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0005262; F:calcium channel activity; IEA:Ensembl.
DR   GO; GO:0017022; F:myosin binding; IEA:Ensembl.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR   GO; GO:0031032; P:actomyosin structure organization; IEA:Ensembl.
DR   GO; GO:0016340; P:calcium-dependent cell-matrix adhesion; IEA:Ensembl.
DR   GO; GO:0010961; P:cellular magnesium ion homeostasis; IEA:InterPro.
DR   GO; GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
DR   GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR   Gene3D; 1.20.5.1010; -; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR004166; MHCK_EF2_kinase.
DR   InterPro; IPR029601; TRPM7.
DR   InterPro; IPR032415; TRPM_tetra.
DR   InterPro; IPR037162; TRPM_tetra_sf.
DR   PANTHER; PTHR13800:SF8; PTHR13800:SF8; 1.
DR   Pfam; PF02816; Alpha_kinase; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF16519; TRPM_tetra; 1.
DR   SMART; SM00811; Alpha_kinase; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51158; ALPHA_KINASE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:A2AI57,
KW   ECO:0000213|PeptideAtlas:A2AI57};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    758    776       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    856    876       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    923    945       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    957    976       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    996   1016       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1078   1096       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1591   1821       Alpha-type protein kinase.
FT                                {ECO:0000259|PROSITE:PS51158}.
SQ   SEQUENCE   1862 AA;  212328 MW;  04C9C634FFA4CC69 CRC64;
     MSQKSWIEST LTKRECVYII PSSKDPHRCL PGCQICQQLV RCFCGRLVKQ HACFTASLAM
     KYSDVKLGEH FNQAIEEWSV EKHTEQSPTD AYGVINFQGG SHSYRAKYVR LSYDTKPEII
     LQLLLKEWQM ELPKLVISVH GGMQKFELHP RIKQLLGKGL IKAAVTTGAW ILTGGVNTGV
     AKHVGDALKE HASRSSRKIC TIGIAPWGVI ENRNDLVGRD VVAPYQTLLN PLSKLNVLNN
     LHSHFILVDD GTVGKYGAEV RLRRELEKTI NQQRIHARIG QGVPVVALIF EGGPNVILTV
     LEYLQESPPV PVVVCEGTGR AADLLAYIHK QTEEGGNLPD AAEPDIISTI KKTFNFGQSE
     AVHLFQTMME CMKKKELITV FHIGSEDHQD IDVAILTALL KGTNASAFDQ LILTLAWDRV
     DIAKNHVFVY GQQWLVGSLE QAMLDALVMD RVSFVKLLIE NGVSMHKFLT IPRLEELYNT
     KQGPTNPMLF HLIRDVKQGN LPPGYKITLI DIGLVIEYLM GGTYRCTYTR KRFRLIYNSL
     GGNNRRSGRN TSSSTPQLRK SHETFGNRAD KKEKMRHNHF IKTAQPYRPK MDASMEEGKK
     KRTKDEIVDI DDPETKRFPY PLNELLIWAC LMKRQVMARF LWQHGEESMA KALVACKIYR
     SMAYEAKQSD LVDDTSEELK QYSNDFGQLA VELLEQSFRQ DETMAMKLLT YELKNWSNST
     CLKLAVSSRL RPFVAHTCTQ MLLSDMWMGR LNMRKNSWYK VILSILVPPA ILMLEYKTKA
     EMSHIPQSQD AHQMTMEDSE NNFHNITEEI PMEVFKEVKI LDSSDGKNEM EIHIKSKKLP
     ITRKFYAFYH APIVKFWFNT LAYLGFLMLY TFVVLVKMEQ LPSVQEWIVI AYIFTYAIEK
     VREVFMSEAG KISQKIKVWF SDYFNVSDTI AIISFFVGFG LRFGAKWNYI NAYDNHVFVA
     GRLIYCLNII FWYVRLLDFL AVNQQAGPYV MMIGKMVANM FYIVVIMALV LLSFGVPRKA
     ILYPHEEPSW SLAKDIVFHP YWMIFGEVYA YEIDVCANDS TLPTICGPGT WLTPFLQAVY
     LFVQYIIMVN LLIAFFNNVY LQVKAISNIV WKYQRYHFIM AYHEKPVLPP PLIILSHIVS
     LFCCVCKRRK KDKTSDGPKL FLTEEDQKKL HDFEEQCVEM YFDEKDDKFN SGSEERIRVT
     FERVEQMSIQ IKEVGDRVNY IKRSLQSLDS QIGHLQDLSA LTVDTLKTLT AQKASEASKV
     HNEITRELSI SKHLAQNLID DVPVRPLWKK PSAVNTLSSS LPQGDRESNN PFLCNIFMKD
     EKDPQYNLFG QDLPVIPQRK EFNIPEAGSS CGALFPSAVS PPELRQRRHG VEMLKIFNKN
     QKLGSSPNSS PHMSSPPTKF SVSTPSQPSC KSHLESTTKD QEPIFYKAAE GDNIEFGAFV
     GHRDSMDLQR FKETSNKIRE LLSNDTPENT LKHVGAAGYS ECCKTSTSLH SVQESCSRRA
     STEDSPEVDS KAALLPDWLR DRPSNREMPS EGGTLNGLAS PFKPVLDTNY YYSAVERNNL
     MRLSQSIPFV PVPPRGEPVT VYRLEESSPS ILNNSMSSWS QLGLCAKIEF LSKEEMGGGL
     RRAVKVLCTW SEHDILKSGH LYIIKSFLPE VINTWSSIYK EDTVLHLCLR EIQQQRAAQK
     LTFAFNQMKP KSIPYSPRFL EVFLLYCHSA GQWFAVEECM TGEFRKYNNN NGDEIIPTNT
     LEEIMLAFSH WTYEYTRGEL LVLDLQGVGE NLTDPSVIKA EEKRSCDMVF GPANLGEDAI
     KNFRAKHHCN SCCRKLKLPD LKRNDYTPDK IIFPQDESSD LNLQSGNSTK ESEATNSVRL
     ML
//
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