ID A2B6Q7_HELPX Unreviewed; 152 AA.
AC A2B6Q7;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 13-SEP-2023, entry version 61.
DE RecName: Full=indole-3-glycerol-phosphate synthase {ECO:0000256|ARBA:ARBA00012362};
DE EC=4.1.1.48 {ECO:0000256|ARBA:ARBA00012362};
DE Flags: Fragment;
GN Name=trpC {ECO:0000313|EMBL:CAL90303.1};
OS Helicobacter pylori (Campylobacter pylori).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=210 {ECO:0000313|EMBL:CAL90303.1};
RN [1] {ECO:0000313|EMBL:CAL90303.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hpylori_ku216 {ECO:0000313|EMBL:CAL90303.1};
RA Linz B., Balloux F., Moodley Y., Manica A., Liu H., Roumagnac P.,
RA Falush D., Stamer C., Prugnolle F., van der Merwe S.W., Yamaoka Y.,
RA Graham D.Y., Perez-Trallero E., Wadstrom T., Suerbaum S., Achtman M.;
RT "An African origin for the intimate association between humans and
RT Helicobacter pylori.";
RL Nature 0:0-0(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001633};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 4/5. {ECO:0000256|ARBA:ARBA00004696}.
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DR EMBL; AM416280; CAL90303.1; -; Genomic_DNA.
DR AlphaFoldDB; A2B6Q7; -.
DR UniPathway; UPA00035; UER00043.
DR GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00331; IGPS; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR22854:SF2; INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE; 1.
DR PANTHER; PTHR22854; TRYPTOPHAN BIOSYNTHESIS PROTEIN; 1.
DR Pfam; PF00218; IGPS; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW Isomerase {ECO:0000313|EMBL:CAL90303.1};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Tryptophan biosynthesis {ECO:0000256|ARBA:ARBA00022822}.
FT DOMAIN 1..152
FT /note="Indole-3-glycerol phosphate synthase"
FT /evidence="ECO:0000259|Pfam:PF00218"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAL90303.1"
FT NON_TER 152
FT /evidence="ECO:0000313|EMBL:CAL90303.1"
SQ SEQUENCE 152 AA; 17024 MW; 160317766978110E CRC64;
CISVLADSKY FLGSYENIKI VSQHSNKPVL CKDFIIDAFQ IKLARVMGAN AVLLMLSVLD
DKNYLELFNL AKSLNMSVLT EVSNKQEIEC LLKFQYDIIG INNRDLHTLT TDINNTLKLR
SLLPKDALVV SESGIYSHAQ IKALAPYVNG FL
//