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Database: UniProt
Entry: A2B7P8_HELPX
LinkDB: A2B7P8_HELPX
Original site: A2B7P8_HELPX 
ID   A2B7P8_HELPX            Unreviewed;       152 AA.
AC   A2B7P8;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   13-SEP-2023, entry version 64.
DE   RecName: Full=indole-3-glycerol-phosphate synthase {ECO:0000256|ARBA:ARBA00012362};
DE            EC=4.1.1.48 {ECO:0000256|ARBA:ARBA00012362};
DE   Flags: Fragment;
GN   Name=trpC {ECO:0000313|EMBL:CAL90644.1};
OS   Helicobacter pylori (Campylobacter pylori).
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=210 {ECO:0000313|EMBL:CAL90644.1};
RN   [1] {ECO:0000313|EMBL:CAL90644.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Hpylori_SA155A1 {ECO:0000313|EMBL:CAL90644.1};
RA   Linz B., Balloux F., Moodley Y., Manica A., Liu H., Roumagnac P.,
RA   Falush D., Stamer C., Prugnolle F., van der Merwe S.W., Yamaoka Y.,
RA   Graham D.Y., Perez-Trallero E., Wadstrom T., Suerbaum S., Achtman M.;
RT   "An African origin for the intimate association between humans and
RT   Helicobacter pylori.";
RL   Nature 0:0-0(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC         = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC         Evidence={ECO:0000256|ARBA:ARBA00001633};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5. {ECO:0000256|ARBA:ARBA00004696}.
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DR   EMBL; AM416621; CAL90644.1; -; Genomic_DNA.
DR   AlphaFoldDB; A2B7P8; -.
DR   UniPathway; UPA00035; UER00043.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00331; IGPS; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR22854:SF2; INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE; 1.
DR   PANTHER; PTHR22854; TRYPTOPHAN BIOSYNTHESIS PROTEIN; 1.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW   Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW   Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW   Isomerase {ECO:0000313|EMBL:CAL90644.1};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Tryptophan biosynthesis {ECO:0000256|ARBA:ARBA00022822}.
FT   DOMAIN          1..152
FT                   /note="Indole-3-glycerol phosphate synthase"
FT                   /evidence="ECO:0000259|Pfam:PF00218"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CAL90644.1"
FT   NON_TER         152
FT                   /evidence="ECO:0000313|EMBL:CAL90644.1"
SQ   SEQUENCE   152 AA;  17043 MW;  165EC4CE36419180 CRC64;
     CISVLADSKY FLGSYENIKI VSKHSTKPIL CKDFIIDSFQ VKLARVMGAN AVLLMLSALD
     DKNYLELFEL AKSLNMSVLT EVSNKQEIER LLKLQYDIIG INNRDLHTLK TDALHTLELR
     SLLPKDALII SESGIHSHAQ IKALAPYVNG FL
//
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