ID A2BE32_MOUSE Unreviewed; 847 AA.
AC A2BE32;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 126.
DE SubName: Full=Vomeronasal 2, receptor 121 {ECO:0000313|Ensembl:ENSMUSP00000092067.4};
GN Name=Vmn2r121 {ECO:0000313|Ensembl:ENSMUSP00000092067.4,
GN ECO:0000313|MGI:MGI:3643045};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000092067.4, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000092067.4, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000092067.4,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000092067.4}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000092067.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; NP_001094086.1; NM_001100616.1.
DR AlphaFoldDB; A2BE32; -.
DR SMR; A2BE32; -.
DR STRING; 10090.ENSMUSP00000092067; -.
DR PaxDb; 10090-ENSMUSP00000092067; -.
DR DNASU; 100038941; -.
DR Ensembl; ENSMUST00000094491.5; ENSMUSP00000092067.4; ENSMUSG00000072049.7.
DR GeneID; 100038941; -.
DR KEGG; mmu:100038941; -.
DR UCSC; uc009uep.1; mouse.
DR AGR; MGI:3643045; -.
DR CTD; 100038941; -.
DR MGI; MGI:3643045; Vmn2r121.
DR VEuPathDB; HostDB:ENSMUSG00000072049; -.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT00950000183069; -.
DR HOGENOM; CLU_005389_5_0_1; -.
DR InParanoid; A2BE32; -.
DR OMA; WRIWITT; -.
DR OrthoDB; 5533520at2759; -.
DR PhylomeDB; A2BE32; -.
DR TreeFam; TF340115; -.
DR BioGRID-ORCS; 100038941; 2 hits in 53 CRISPR screens.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; A2BE32; Protein.
DR ExpressionAtlas; A2BE32; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR CDD; cd06365; PBP1_pheromone_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF411; VOMERONASAL 2, RECEPTOR 10-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..847
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002642201"
FT TRANSMEM 581..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 618..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 651..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 695..719
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 739..763
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 775..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 807..830
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 581..845
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 847 AA; 96753 MW; 3F37916FCD0A8B47 CRC64;
MKKLCAFTIS FLFLKFSLIL CCLSEPSCFW RIRNSEDSDG DLQRECHFYL WLIDESIEDN
FVSDLNFRIA ASEYELLLVI FFATDEINKN SYLLPNMTLM FSIIGGNCHD LLRSLDQEYT
EIKGHMNFVN YFCYLDDSCA IGFTGPSWKT SLKLGLHSSM PLVFFGPFNP NLRDHDRLPH
VHQVATKDTH LSHGMVSLMF HFRWTWIGLV ISDDDQGIQF LSDLREESQR HEICLAFVNM
IPENMQIYMT RATIYDKQIM TSSANVVIIY GEMNSTLEVS FRRWEELGAW RIWITTSQWD
VIKNKKEFTF NLFHGTITFA HHKVEIPKFK KFMQTMNTAK YPVDISHTIL EWNYFNCSIS
KNSSKMDHMT FNNTLEWTAL HNYDMAMSDE GYNLYNAVYA AAHTYHEHIL QQVESQKKAK
PKRYFTACQQ VSSLMKTRVF SNPVGELVNM KHRENQCTEY DIFIIWNFPQ GLGLKVKIGS
YIPCFPKSQQ LHICDDLEWA MGGTVPSSVC SVACTAGFRK IHQEETADCC FDCVQCPENE
VSNETADMEQ CVRCPDDKYA NIEQTHCLSR AVSFLAYEDP LGMALGCMAL SFSAITILVL
VTFVKYKDTP IVKANNRILS YILLISLVFC FLCSLLFIGH PNQVSCILQQ TIFGVFFTVS
VSTVLAKTIT VVMAFKLTTP GRRIRGMMMT GAPKLVIPIC TLIQLVLCGI WLVTSPPFID
RDIQSEHGKT VILCNKGSVI AFHVVLGYLG SLALGSFTLA FLARNLPDTF NEAKFLTFSM
LVFCSVWITF LPVYHSTRGR VMVVVEVFSI LASSAGLLMC IFVPKCYVIL IRPDSNFIKK
HKGKLLN
//
