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Database: UniProt
Entry: A2BE66_DANRE
LinkDB: A2BE66_DANRE
Original site: A2BE66_DANRE 
ID   A2BE66_DANRE            Unreviewed;       327 AA.
AC   A2BE66; A0A8M1P2F1;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 2.
DT   24-JAN-2024, entry version 119.
DE   SubName: Full=Homeobox C10a {ECO:0000313|Ensembl:ENSDARP00000053294};
DE   SubName: Full=Homeobox protein Hox-C10 {ECO:0000313|RefSeq:NP_001241873.1};
GN   Name=hoxc10 {ECO:0000313|RefSeq:NP_001241873.1};
GN   Synonyms=z-81 {ECO:0000313|RefSeq:NP_001241873.1};
GN   OrderedLocusNames=hoxc10a {ECO:0000313|Ensembl:ENSDARP00000053294,
GN   ECO:0000313|RefSeq:NP_001241873.1,
GN   ECO:0000313|ZFIN:ZDB-GENE-990415-110};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000053294};
RN   [1] {ECO:0000313|RefSeq:NP_001241873.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001241873.1};
RX   PubMed=8882497;
RA   Misof B.Y., Blanco M.J., Wagner G.P.;
RT   "PCR-survey of Hox-genes of the zebrafish: new sequence information and
RT   evolutionary implications.";
RL   J. Exp. Zool. 274:193-206(1996).
RN   [2] {ECO:0000313|RefSeq:NP_001241873.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001241873.1};
RX   PubMed=9425136;
RA   Prince V.E., Joly L., Ekker M., Ho R.K.;
RT   "Zebrafish hox genes: genomic organization and modified colinear expression
RT   patterns in the trunk.";
RL   Development 125:407-420(1998).
RN   [3] {ECO:0000313|RefSeq:NP_001241873.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001241873.1};
RX   PubMed=9831563; DOI=10.1126/science.282.5394.1711;
RA   Amores A., Force A., Yan Y.L., Joly L., Amemiya C., Fritz A., Ho R.K.,
RA   Langeland J., Prince V., Wang Y.L., Westerfield M., Ekker M.,
RA   Postlethwait J.H.;
RT   "Zebrafish hox clusters and vertebrate genome evolution.";
RL   Science 282:1711-1714(1998).
RN   [4] {ECO:0000313|RefSeq:NP_001241873.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001241873.1};
RX   PubMed=10801442;
RA   Feldman B., Dougan S.T., Schier A.F., Talbot W.S.;
RT   "Nodal-related signals establish mesendodermal fate and trunk neural
RT   identity in zebrafish.";
RL   Curr. Biol. 10:531-534(2000).
RN   [5] {ECO:0000313|RefSeq:NP_001241873.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001241873.1};
RX   PubMed=11133157; DOI=10.1006/dbio.2000.9967;
RA   Winkler C., Moon R.T.;
RT   "Zebrafish mdk2, a novel secreted midkine, participates in posterior
RT   neurogenesis.";
RL   Dev. Biol. 229:102-118(2001).
RN   [6] {ECO:0000313|Ensembl:ENSDARP00000053294, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000053294};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RG   Genome Reference Consortium Zebrafish;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA   Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA   Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA   Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA   Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA   Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA   Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA   Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA   Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA   Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA   Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA   Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA   Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA   Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA   Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA   Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA   Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA   Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA   Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA   Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [7] {ECO:0000313|Ensembl:ENSDARP00000053294}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000053294};
RG   Ensembl;
RL   Submitted (AUG-2013) to UniProtKB.
RN   [8] {ECO:0000313|RefSeq:NP_001241873.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001241873.1};
RX   PubMed=26335559;
RA   Hayward AG 2.n.d., Joshi P., Skromne I.;
RT   "Spatiotemporal analysis of zebrafish hox gene regulation by Cdx4.";
RL   Dev. Dyn. 244:1564-1573(2015).
RN   [9] {ECO:0000313|RefSeq:NP_001241873.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001241873.1};
RX   PubMed=26018586; DOI=10.1111/joa.12324;
RA   Tanaka M., Yu R., Kurokawa D.;
RT   "Anterior migration of lateral plate mesodermal cells during embryogenesis
RT   of the pufferfish Takifugu niphobles: insight into the rostral positioning
RT   of pelvic fins.";
RL   J. Anat. 227:81-88(2015).
RN   [10] {ECO:0000313|RefSeq:NP_001241873.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001241873.1};
RX   PubMed=26469318;
RA   Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA   Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA   Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA   Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA   Reith W., Hertzano R.;
RT   "RFX transcription factors are essential for hearing in mice.";
RL   Nat. Commun. 6:8549-8549(2015).
RN   [11] {ECO:0000313|RefSeq:NP_001241873.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001241873.1};
RX   PubMed=27376691;
RA   Payumo A.Y., McQuade L.E., Walker W.J., Yamazoe S., Chen J.K.;
RT   "Tbx16 regulates hox gene activation in mesodermal progenitor cells.";
RL   Nat. Chem. Biol. 12:694-701(2016).
RN   [12] {ECO:0000313|RefSeq:NP_001241873.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001241873.1};
RX   PubMed=29684203;
RA   Malmstrom M., Britz R., Matschiner M., Torresen O.K., Hadiaty R.K.,
RA   Yaakob N., Tan H.H., Jakobsen K.S., Salzburger W., Ruber L.;
RT   "The Most Developmentally Truncated Fishes Show Extensive Hox Gene Loss and
RT   Miniaturized Genomes.";
RL   Genome Biol. Evol. 10:1088-1103(2018).
RN   [13] {ECO:0000313|RefSeq:NP_001241873.1}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001241873.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC       {ECO:0000256|ARBA:ARBA00003263}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family.
CC       {ECO:0000256|ARBA:ARBA00006317}.
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DR   EMBL; BX005254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX465864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001241873.1; NM_001254944.1.
DR   Ensembl; ENSDART00000053295; ENSDARP00000053294; ENSDARG00000070348.
DR   Ensembl; ENSDART00000053295.7; ENSDARP00000053294.6; ENSDARG00000070348.6.
DR   GeneID; 100535576; -.
DR   KEGG; dre:100535576; -.
DR   CTD; 100535576; -.
DR   ZFIN; ZDB-GENE-990415-110; hoxc10a.
DR   HOGENOM; CLU_057871_0_0_1; -.
DR   OrthoDB; 728401at2759; -.
DR   TreeFam; TF317819; -.
DR   Proteomes; UP000000437; Chromosome 23.
DR   Bgee; ENSDARG00000070348; Expressed in tail bud paraxial mesoderm and 20 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR046333; HXA10/ABDB-like.
DR   PANTHER; PTHR45874; HOMEOBOX PROTEIN ABDOMINAL-B; 1.
DR   PANTHER; PTHR45874:SF2; HOMEOBOX PROTEIN HOX-C10; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          252..312
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DNA_BIND        254..313
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          131..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          194..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        138..157
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        202..238
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   327 AA;  36989 MW;  E01381999A5411AE CRC64;
     MSCPNNVAAN AFLMDSLVGG TSPFRGESYS SNSGMYMQTS AEYGCSMMGS FGIVGTPLSK
     RDDLQPSGMH LGSYQHSHYL SQRDTWIAGS KTYRGSQPVA QPLHPCSFPA SNVKEEAIPC
     LYQPDIDSAK ESGEKSTYIR LGDNNSHPNQ SAVSTPDYFR RSQVYASERG HHGDEFGSDF
     NPIPRISTPV EALASDSCVK SSKARQHPED KGGNTQEDDM DQRQTRKEES VSKTESYESK
     LEKATGNWLK AKSGRKKRCP YTKHQTLELE KEFLFNMYLT RERRLEISKS INLTDRQVKI
     WFQNRRMKLK KLNRESRVRE LTGYSFN
//
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