ID A2BE66_DANRE Unreviewed; 327 AA.
AC A2BE66; A0A8M1P2F1;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 24-JAN-2024, entry version 119.
DE SubName: Full=Homeobox C10a {ECO:0000313|Ensembl:ENSDARP00000053294};
DE SubName: Full=Homeobox protein Hox-C10 {ECO:0000313|RefSeq:NP_001241873.1};
GN Name=hoxc10 {ECO:0000313|RefSeq:NP_001241873.1};
GN Synonyms=z-81 {ECO:0000313|RefSeq:NP_001241873.1};
GN OrderedLocusNames=hoxc10a {ECO:0000313|Ensembl:ENSDARP00000053294,
GN ECO:0000313|RefSeq:NP_001241873.1,
GN ECO:0000313|ZFIN:ZDB-GENE-990415-110};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000053294};
RN [1] {ECO:0000313|RefSeq:NP_001241873.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001241873.1};
RX PubMed=8882497;
RA Misof B.Y., Blanco M.J., Wagner G.P.;
RT "PCR-survey of Hox-genes of the zebrafish: new sequence information and
RT evolutionary implications.";
RL J. Exp. Zool. 274:193-206(1996).
RN [2] {ECO:0000313|RefSeq:NP_001241873.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001241873.1};
RX PubMed=9425136;
RA Prince V.E., Joly L., Ekker M., Ho R.K.;
RT "Zebrafish hox genes: genomic organization and modified colinear expression
RT patterns in the trunk.";
RL Development 125:407-420(1998).
RN [3] {ECO:0000313|RefSeq:NP_001241873.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001241873.1};
RX PubMed=9831563; DOI=10.1126/science.282.5394.1711;
RA Amores A., Force A., Yan Y.L., Joly L., Amemiya C., Fritz A., Ho R.K.,
RA Langeland J., Prince V., Wang Y.L., Westerfield M., Ekker M.,
RA Postlethwait J.H.;
RT "Zebrafish hox clusters and vertebrate genome evolution.";
RL Science 282:1711-1714(1998).
RN [4] {ECO:0000313|RefSeq:NP_001241873.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001241873.1};
RX PubMed=10801442;
RA Feldman B., Dougan S.T., Schier A.F., Talbot W.S.;
RT "Nodal-related signals establish mesendodermal fate and trunk neural
RT identity in zebrafish.";
RL Curr. Biol. 10:531-534(2000).
RN [5] {ECO:0000313|RefSeq:NP_001241873.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001241873.1};
RX PubMed=11133157; DOI=10.1006/dbio.2000.9967;
RA Winkler C., Moon R.T.;
RT "Zebrafish mdk2, a novel secreted midkine, participates in posterior
RT neurogenesis.";
RL Dev. Biol. 229:102-118(2001).
RN [6] {ECO:0000313|Ensembl:ENSDARP00000053294, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000053294};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [7] {ECO:0000313|Ensembl:ENSDARP00000053294}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000053294};
RG Ensembl;
RL Submitted (AUG-2013) to UniProtKB.
RN [8] {ECO:0000313|RefSeq:NP_001241873.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001241873.1};
RX PubMed=26335559;
RA Hayward AG 2.n.d., Joshi P., Skromne I.;
RT "Spatiotemporal analysis of zebrafish hox gene regulation by Cdx4.";
RL Dev. Dyn. 244:1564-1573(2015).
RN [9] {ECO:0000313|RefSeq:NP_001241873.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001241873.1};
RX PubMed=26018586; DOI=10.1111/joa.12324;
RA Tanaka M., Yu R., Kurokawa D.;
RT "Anterior migration of lateral plate mesodermal cells during embryogenesis
RT of the pufferfish Takifugu niphobles: insight into the rostral positioning
RT of pelvic fins.";
RL J. Anat. 227:81-88(2015).
RN [10] {ECO:0000313|RefSeq:NP_001241873.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001241873.1};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [11] {ECO:0000313|RefSeq:NP_001241873.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001241873.1};
RX PubMed=27376691;
RA Payumo A.Y., McQuade L.E., Walker W.J., Yamazoe S., Chen J.K.;
RT "Tbx16 regulates hox gene activation in mesodermal progenitor cells.";
RL Nat. Chem. Biol. 12:694-701(2016).
RN [12] {ECO:0000313|RefSeq:NP_001241873.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001241873.1};
RX PubMed=29684203;
RA Malmstrom M., Britz R., Matschiner M., Torresen O.K., Hadiaty R.K.,
RA Yaakob N., Tan H.H., Jakobsen K.S., Salzburger W., Ruber L.;
RT "The Most Developmentally Truncated Fishes Show Extensive Hox Gene Loss and
RT Miniaturized Genomes.";
RL Genome Biol. Evol. 10:1088-1103(2018).
RN [13] {ECO:0000313|RefSeq:NP_001241873.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001241873.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC {ECO:0000256|ARBA:ARBA00003263}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family.
CC {ECO:0000256|ARBA:ARBA00006317}.
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DR EMBL; BX005254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX465864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001241873.1; NM_001254944.1.
DR Ensembl; ENSDART00000053295; ENSDARP00000053294; ENSDARG00000070348.
DR Ensembl; ENSDART00000053295.7; ENSDARP00000053294.6; ENSDARG00000070348.6.
DR GeneID; 100535576; -.
DR KEGG; dre:100535576; -.
DR CTD; 100535576; -.
DR ZFIN; ZDB-GENE-990415-110; hoxc10a.
DR HOGENOM; CLU_057871_0_0_1; -.
DR OrthoDB; 728401at2759; -.
DR TreeFam; TF317819; -.
DR Proteomes; UP000000437; Chromosome 23.
DR Bgee; ENSDARG00000070348; Expressed in tail bud paraxial mesoderm and 20 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR046333; HXA10/ABDB-like.
DR PANTHER; PTHR45874; HOMEOBOX PROTEIN ABDOMINAL-B; 1.
DR PANTHER; PTHR45874:SF2; HOMEOBOX PROTEIN HOX-C10; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 252..312
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 254..313
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 131..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 327 AA; 36989 MW; E01381999A5411AE CRC64;
MSCPNNVAAN AFLMDSLVGG TSPFRGESYS SNSGMYMQTS AEYGCSMMGS FGIVGTPLSK
RDDLQPSGMH LGSYQHSHYL SQRDTWIAGS KTYRGSQPVA QPLHPCSFPA SNVKEEAIPC
LYQPDIDSAK ESGEKSTYIR LGDNNSHPNQ SAVSTPDYFR RSQVYASERG HHGDEFGSDF
NPIPRISTPV EALASDSCVK SSKARQHPED KGGNTQEDDM DQRQTRKEES VSKTESYESK
LEKATGNWLK AKSGRKKRCP YTKHQTLELE KEFLFNMYLT RERRLEISKS INLTDRQVKI
WFQNRRMKLK KLNRESRVRE LTGYSFN
//