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Database: UniProt
Entry: A2C0D7_PROM1
LinkDB: A2C0D7_PROM1
Original site: A2C0D7_PROM1 
ID   A2C0D7_PROM1            Unreviewed;       805 AA.
AC   A2C0D7;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   24-JAN-2024, entry version 96.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   Name=uvrD {ECO:0000313|EMBL:ABM74947.1};
GN   OrderedLocusNames=NATL1_03831 {ECO:0000313|EMBL:ABM74947.1};
OS   Prochlorococcus marinus (strain NATL1A).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales;
OC   Prochlorococcaceae; Prochlorococcus.
OX   NCBI_TaxID=167555 {ECO:0000313|EMBL:ABM74947.1, ECO:0000313|Proteomes:UP000002592};
RN   [1] {ECO:0000313|Proteomes:UP000002592}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NATL1A {ECO:0000313|Proteomes:UP000002592};
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC         translocating in the 3'-5' direction.; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034617};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|ARBA:ARBA00009922}.
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DR   EMBL; CP000553; ABM74947.1; -; Genomic_DNA.
DR   RefSeq; WP_011823145.1; NC_008819.1.
DR   AlphaFoldDB; A2C0D7; -.
DR   KEGG; pme:NATL1_03831; -.
DR   eggNOG; COG0210; Bacteria.
DR   HOGENOM; CLU_004585_5_2_3; -.
DR   OMA; YQDTNRT; -.
DR   Proteomes; UP000002592; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   CDD; cd18807; SF1_C_UvrD; 1.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Helicase {ECO:0000256|PROSITE-ProRule:PRU00560,
KW   ECO:0000313|EMBL:ABM74947.1};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}.
FT   DOMAIN          10..344
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          345..621
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   REGION          727..752
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          562..589
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   BINDING         31..38
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   805 AA;  91221 MW;  1326A64F43C56F29 CRC64;
     MKQSNSIFLN GLNEAQSHAV DHFHGPLLVV AGAGSGKTRA LTHRIAHLIT EYKVDPSSIL
     AVTFTNKAAR EMKDRLELLL AKRLSSLTHG KPWTALQVAE QREIRNRIHR EISRELWIGT
     FHALFSRLLR FDIDKFKDPE GLTWTKQFSI YDETDAQSLI KEIVTQDLQL DPKRFEPKKV
     RWAISNAKNQ CLLPDDLSNN QEGQRGKLVA ETYRLYRKAL AANNALDFDD LLLIPVQLLQ
     QNEKIRTYWH SRFKHVLVDE YQDTNWTQYE LIKQLVTNGK DPSSFQDWNN RSVFVVGDAD
     QSIYSFRAAD FRILMGFQED FGKKSLDNTY DSTLVKLEEN YRSTSTILEA ANSLISNNKE
     RIDKVLRATR GEGEPIRLTR CDDEIAEAEA VIHRLRILDA SNPELNWGDM AILYRTNAQS
     RAIEDSLVRW SIPYIVVGGL RFYDRREIKD LLAYLRLLIN PSDSVSLLRV LNVPKRGIGK
     TTVQRLSDAA SQLKIPLWEV VNDPEAVRSL AGRSAKGLLI FSELINELQS HLLSSSPAEL
     VQLVLEKSGY LSELIATGTD EAEERRRNLQ ELVNAALQYQ EESEDANLEG FLSTAALSSD
     ADNKDTASNR VTLMTLHSSK GLEFPVVCLV GMEQGLFPSY RSLDDPSSLE EERRLCYVGL
     TRAKEKLFLF HASERRMWGG MREPAIASIF LSEIPEELVK GDIPLSGGAT LRREKNLDRL
     TRIDRQSNKK SFPREAENAV RKTYSGPSPG KRWSVNDRVE HSSFGEGIIT HVFGSGEKIS
     LAIKFSGMGP KILDPRLAPL KLIDE
//
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