ID A2C7T3_PROM3 Unreviewed; 334 AA.
AC A2C7T3;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=protochlorophyllide reductase {ECO:0000256|ARBA:ARBA00012006};
DE EC=1.3.1.33 {ECO:0000256|ARBA:ARBA00012006};
GN OrderedLocusNames=P9303_07921 {ECO:0000313|EMBL:ABM77543.1};
OS Prochlorococcus marinus (strain MIT 9303).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales;
OC Prochlorococcaceae; Prochlorococcus.
OX NCBI_TaxID=59922 {ECO:0000313|EMBL:ABM77543.1, ECO:0000313|Proteomes:UP000002274};
RN [1] {ECO:0000313|EMBL:ABM77543.1, ECO:0000313|Proteomes:UP000002274}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT 9303 {ECO:0000313|EMBL:ABM77543.1,
RC ECO:0000313|Proteomes:UP000002274};
RX PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA Richardson P., Chisholm S.W.;
RT "Patterns and implications of gene gain and loss in the evolution of
RT Prochlorococcus.";
RL PLoS Genet. 3:2515-2528(2007).
CC -!- FUNCTION: Phototransformation of protochlorophyllide (Pchlide) to
CC chlorophyllide (Chlide). {ECO:0000256|ARBA:ARBA00004055}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chlorophyllide a + NADP(+) = H(+) + NADPH +
CC protochlorophyllide a; Xref=Rhea:RHEA:11132, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:83348,
CC ChEBI:CHEBI:83350; EC=1.3.1.33;
CC Evidence={ECO:0000256|ARBA:ARBA00000071};
CC -!- PATHWAY: Porphyrin-containing compound metabolism; chlorophyll
CC biosynthesis. {ECO:0000256|ARBA:ARBA00005173}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. POR subfamily. {ECO:0000256|ARBA:ARBA00005821}.
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DR EMBL; CP000554; ABM77543.1; -; Genomic_DNA.
DR AlphaFoldDB; A2C7T3; -.
DR STRING; 59922.P9303_07921; -.
DR KEGG; pmf:P9303_07921; -.
DR HOGENOM; CLU_010194_44_3_3; -.
DR BioCyc; PMAR59922:G1G80-718-MONOMER; -.
DR UniPathway; UPA00668; -.
DR Proteomes; UP000002274; Chromosome.
DR GO; GO:0016630; F:protochlorophyllide reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0015979; P:photosynthesis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005979; Prochl_reduct.
DR InterPro; IPR002347; SDR_fam.
DR NCBIfam; TIGR01289; LPOR; 1.
DR PANTHER; PTHR44419; PROTOCHLOROPHYLLIDE REDUCTASE C, CHLOROPLASTIC; 1.
DR PANTHER; PTHR44419:SF15; PROTOCHLOROPHYLLIDE REDUCTASE C, CHLOROPLASTIC; 1.
DR Pfam; PF00106; adh_short; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Chlorophyll biosynthesis {ECO:0000256|ARBA:ARBA00023171};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ABM77543.1};
KW Photosynthesis {ECO:0000256|ARBA:ARBA00022531}.
SQ SEQUENCE 334 AA; 36656 MW; ED60C837AE85344D CRC64;
MASSQASPGT VLITGTTSGV GLYACKALVY RGWQVITANR HPLRAVAAAE RVGIPAAQLQ
HLRMDLSDLQ SVRDGVETLL GSLEQPLDAL VCNAAVYQPR LRKPKRSAQG YELSMATNHF
GHFLLIQLLL ENLGKAKVFQ SARGSYLSAA RVVILGTVTA NYKELGGKIP IPAPADLGNL
SGFEQGFHAP ISMASGKSFK PGKAYKDSKL CNMITTQELH RRLHEESGIL FTSLYPGCVA
DTPLFRYTPK IFRFLFPIFQ RLITGGYVTQ AKAGQRVAQV VTNPEFGVSG VHWSWGNRQK
KNRESFRQEL SERATDPITA KRVWELSMKL VGLT
//
