ID POC1B_DANRE Reviewed; 490 AA.
AC A2CEH0; Q6TEQ1; Q7SXR5;
DT 10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 111.
DE RecName: Full=POC1 centriolar protein homolog B {ECO:0000250|UniProtKB:Q8TC44};
DE AltName: Full=WD repeat domain 51B {ECO:0000312|EMBL:CAM15113.1};
GN Name=poc1b {ECO:0000312|ZFIN:ZDB-GENE-031118-54};
GN Synonyms=tuwd12, wdr51b {ECO:0000312|EMBL:AAH55275.1,
GN ECO:0000312|ZFIN:ZDB-GENE-031118-54}; ORFNames=si:dkey-164B12.2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000312|EMBL:AAQ97974.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney marrow {ECO:0000312|EMBL:AAQ97974.1};
RX PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA Look A.T., Chen Z.;
RT "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000312|EMBL:CAM15113.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB {ECO:0000312|EMBL:AAH55275.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP FUNCTION.
RX PubMed=20008567; DOI=10.1083/jcb.200908019;
RA Pearson C.G., Osborn D.P., Giddings T.H. Jr., Beales P.L., Winey M.;
RT "Basal body stability and ciliogenesis requires the conserved component
RT Poc1.";
RL J. Cell Biol. 187:905-920(2009).
CC -!- FUNCTION: Plays an important role in centriole assembly and/or
CC stability and ciliogenesis. Involved in early steps of centriole
CC duplication, as well as in the later steps of centriole length control.
CC {ECO:0000250|UniProtKB:Q8TC44, ECO:0000269|PubMed:20008567}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriole {ECO:0000250|UniProtKB:Q8TC44}.
CC -!- SIMILARITY: Belongs to the WD repeat POC1 family. {ECO:0000305}.
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DR EMBL; AY422998; AAQ97974.1; -; mRNA.
DR EMBL; CR405685; CAM15113.1; -; Genomic_DNA.
DR EMBL; CT033837; CAM15113.1; JOINED; Genomic_DNA.
DR EMBL; BC055275; AAH55275.1; -; mRNA.
DR RefSeq; NP_956412.1; NM_200118.1.
DR AlphaFoldDB; A2CEH0; -.
DR SMR; A2CEH0; -.
DR STRING; 7955.ENSDARP00000026057; -.
DR PaxDb; 7955-ENSDARP00000026057; -.
DR PeptideAtlas; A2CEH0; -.
DR GeneID; 386932; -.
DR KEGG; dre:386932; -.
DR AGR; ZFIN:ZDB-GENE-031118-54; -.
DR ZFIN; ZDB-GENE-031118-54; poc1b.
DR eggNOG; ENOG502QSVJ; Eukaryota.
DR HOGENOM; CLU_000288_57_17_1; -.
DR InParanoid; A2CEH0; -.
DR OMA; MIKFHPK; -.
DR OrthoDB; 2575345at2759; -.
DR PhylomeDB; A2CEH0; -.
DR TreeFam; TF324210; -.
DR PRO; PR:A2CEH0; -.
DR Proteomes; UP000000437; Alternate scaffold 25.
DR Proteomes; UP000000437; Chromosome 25.
DR Bgee; ENSDARG00000021110; Expressed in blastula and 20 other cell types or tissues.
DR GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0007099; P:centriole replication; ISS:UniProtKB.
DR GO; GO:0060271; P:cilium assembly; IMP:ZFIN.
DR GO; GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; IMP:ZFIN.
DR GO; GO:0007507; P:heart development; IMP:ZFIN.
DR GO; GO:0007634; P:optokinetic behavior; IMP:ZFIN.
DR GO; GO:0003014; P:renal system process; IMP:ZFIN.
DR GO; GO:0001895; P:retina homeostasis; ISS:UniProtKB.
DR GO; GO:0010842; P:retina layer formation; IMP:ZFIN.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44019:SF1; POC1 CENTRIOLAR PROTEIN HOMOLOG B; 1.
DR PANTHER; PTHR44019; WD REPEAT-CONTAINING PROTEIN 55; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 7.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Cilium biogenesis/degradation; Coiled coil; Cytoplasm; Cytoskeleton;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..490
FT /note="POC1 centriolar protein homolog B"
FT /id="PRO_0000395867"
FT REPEAT 16..55
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 58..97
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 100..139
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 142..181
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 184..223
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 226..265
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REPEAT 268..307
FT /note="WD 7"
FT /evidence="ECO:0000255"
FT REGION 375..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 431..463
FT /evidence="ECO:0000255"
FT COMPBIAS 375..393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..410
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 109
FT /note="H -> N (in Ref. 1; AAQ97974 and 3; AAH55275)"
FT /evidence="ECO:0000305"
FT CONFLICT 179
FT /note="I -> T (in Ref. 3; AAH55275)"
FT /evidence="ECO:0000305"
FT CONFLICT 312
FT /note="K -> R (in Ref. 1; AAQ97974 and 3; AAH55275)"
FT /evidence="ECO:0000305"
FT CONFLICT 390
FT /note="S -> L (in Ref. 1; AAQ97974 and 3; AAH55275)"
FT /evidence="ECO:0000305"
FT CONFLICT 393
FT /note="F -> L (in Ref. 1; AAQ97974 and 3; AAH55275)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 490 AA; 54391 MW; 2AEC9999FA2A41A5 CRC64;
MASVMEDPTL ERHFKGHKDV ISCADFNPNN KQLATGSCDK SLMIWNLAPK ARAFRFVGHT
DVITGVNFAP SGSLVASSSR DQTVRLWTPS IKGESTVFKA HTASVRSVHF SRDGQRLVTA
SDDKSVKVWG VERKKFLYSL NRHTNWVRCA RFSPDGRLIA SCGDDRTVRL WDTSSHQCIN
IFTDYGGSAT FVDFNSSGTC IASSGADNTI KIWDIRTNKL IQHYKVHNAG VNCFSFHPSG
NYLISGSSDS TIKILDLLEG RLIYTLHGHK GPVLTVTFSR DGDLFASGGA DSQVLMWKTN
FDSLNYRELL SKHSKRVTPD PPPHLMDIYP RSHHRHHPQN GTVEINPVAD TQSTDPQVVE
VGRVVFSTTD ARNYDGASSS RAQFTSGMDS GPFRTHTQAR EEEDENQEER FAGGMTASPA
ERSGIPSSLT STLENIVQQL DILTQTVAVL EERLTLTEDK LRTCLDNQVL LMQQNQQLDR
SDEESEGPPL
//
