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Database: UniProt
Entry: A2DDX9_TRIVA
LinkDB: A2DDX9_TRIVA
Original site: A2DDX9_TRIVA 
ID   A2DDX9_TRIVA            Unreviewed;       676 AA.
AC   A2DDX9;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   07-JUN-2017, entry version 38.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=TVAG_199440 {ECO:0000313|EMBL:EAY21505.1};
OS   Trichomonas vaginalis.
OC   Eukaryota; Parabasalia; Trichomonadida; Trichomonadidae; Trichomonas.
OX   NCBI_TaxID=5722 {ECO:0000313|EMBL:EAY21505.1, ECO:0000313|Proteomes:UP000001542};
RN   [1] {ECO:0000313|EMBL:EAY21505.1, ECO:0000313|Proteomes:UP000001542}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC PRA-98 / G3 {ECO:0000313|Proteomes:UP000001542};
RX   PubMed=17218520; DOI=10.1126/science.1132894;
RA   Carlton J.M., Hirt R.P., Silva J.C., Delcher A.L., Schatz M., Zhao Q.,
RA   Wortman J.R., Bidwell S.L., Alsmark U.C.M., Besteiro S.,
RA   Sicheritz-Ponten T., Noel C.J., Dacks J.B., Foster P.G., Simillion C.,
RA   Van de Peer Y., Miranda-Saavedra D., Barton G.J., Westrop G.D.,
RA   Mueller S., Dessi D., Fiori P.L., Ren Q., Paulsen I., Zhang H.,
RA   Bastida-Corcuera F.D., Simoes-Barbosa A., Brown M.T., Hayes R.D.,
RA   Mukherjee M., Okumura C.Y., Schneider R., Smith A.J., Vanacova S.,
RA   Villalvazo M., Haas B.J., Pertea M., Feldblyum T.V., Utterback T.R.,
RA   Shu C.L., Osoegawa K., de Jong P.J., Hrdy I., Horvathova L.,
RA   Zubacova Z., Dolezal P., Malik S.B., Logsdon J.M. Jr., Henze K.,
RA   Gupta A., Wang C.C., Dunne R.L., Upcroft J.A., Upcroft P., White O.,
RA   Salzberg S.L., Tang P., Chiu C.-H., Lee Y.-S., Embley T.M.,
RA   Coombs G.H., Mottram J.C., Tachezy J., Fraser-Liggett C.M.,
RA   Johnson P.J.;
RT   "Draft genome sequence of the sexually transmitted pathogen
RT   Trichomonas vaginalis.";
RL   Science 315:207-212(2007).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; DS113190; EAY21505.1; -; Genomic_DNA.
DR   RefSeq; XP_001582491.1; XM_001582441.1.
DR   EnsemblProtists; EAY21505; EAY21505; TVAG_199440.
DR   GeneID; 5467053; -.
DR   KEGG; tva:TVAG_199440; -.
DR   EuPathDB; TrichDB:TVAG_199440; -.
DR   Proteomes; UP000001542; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001542};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001542};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    366    394       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    406    430       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    459    479       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    491    514       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    541    561       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    573    599       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    619    643       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   676 AA;  79640 MW;  D3A253F7EBDF9252 CRC64;
     MNDTEVDYLE INCHEDVVWS AVAELLKNNA VQFHDTNESI IRNPGIESKL QTLTALYNNI
     QAIDKHISTL TDEFIQDDLD TTTDFQNHEP IINQFQLISD TYTQSINEYT SLHKNYKKIE
     IELKILNFII NSTDARPDNS STDLSPQQDR SVYLESLLSN SNAKHIICGI IEEEKFRKFQ
     SNVKQISAGK MEFKNSKYNK FKIYSIRTDE NIRNSLKTVC NEWSILTMCF DDIETVAESI
     FNKNQKLNSV SERMEESKQR FINLIHTNLE NYKKYRNLIK KLYKICSIIS TSNYDQEKNR
     YTIYCWSLPK DFINIRKILE KSNRTDKIIY MDACNPTKKN YTNAPSHFEE NKFFKTDKKF
     HINPNYFIPF HFALFGIIMG DFGFGLLALI YSLFLKLTSK FENKHFVIPI FSMYGGLIYN
     QFFGIPINFF PKSKFYPFGL KPSIYDMPKS FSKISLPRFA IMFMILAFNQ IYAIHCKLVK
     LNKKISTITE YINFVFFCIS FLFIPLLVTV KIFIFSITKK SDILIHIAYI FVYKDSSVFD
     MIYISIWYFS LFMYLFVFPV FKLVPFCHNA IEFLWTLFGS LSTLLVPVCS LLLPFLALLT
     NIVLTFLLNL SWNFYLRTFA FTFFFFCFCI LLLIVFRGVY FLANLVAYIP PYAMFYDDHE
     FTHYQPSSFE NEIQDL
//
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