ID A2ICG6_MUSDO Unreviewed; 390 AA.
AC A2ICG6;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Aspartic proteinase AspMD03 {ECO:0000313|EMBL:ABM69086.1};
DE SubName: Full=Lysosomal aspartic protease-like precursor {ECO:0000313|RefSeq:NP_001273807.1};
GN Name=101894200 {ECO:0000313|EnsemblMetazoa:MDOA014422-PD};
GN Synonyms=LOC101894200 {ECO:0000313|RefSeq:NP_001273807.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EMBL:ABM69086.1};
RN [1] {ECO:0000313|EMBL:ABM69086.1}
RP NUCLEOTIDE SEQUENCE.
RA Padilha M.H.P., Pimentel A.C., Terra W.R.;
RT "Molecular cloning and functional characterization of an aspartic
RT proteinase from Musca domestica.";
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABM69086.1, ECO:0000313|RefSeq:NP_001273807.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19815068; DOI=10.1016/j.ibmb.2009.09.003;
RA Padilha M.H., Pimentel A.C., Ribeiro A.F., Terra W.R.;
RT "Sequence and function of lysosomal and digestive cathepsin D-like
RT proteinases of Musca domestica midgut.";
RL Insect Biochem. Mol. Biol. 39:782-791(2009).
RN [3] {ECO:0000313|RefSeq:NP_001273807.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26156588;
RA Li D., Liang Y., Wang X., Wang L., Qi M., Yu Y., Luan Y.;
RT "Transcriptomic Analysis of Musca domestica to Reveal Key Genes of the
RT Prophenoloxidase-Activating System.";
RL G3 (Bethesda) 5:1827-1841(2015).
RN [4] {ECO:0000313|EnsemblMetazoa:MDOA014422-PD}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA014422-PD};
RG EnsemblMetazoa;
RL Submitted (JAN-2021) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001273807.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR EMBL; EF193385; ABM69086.1; -; mRNA.
DR RefSeq; NP_001273807.1; NM_001286878.1.
DR STRING; 7370.A2ICG6; -.
DR MEROPS; A01.009; -.
DR EnsemblMetazoa; MDOA014422-RD; MDOA014422-PD; MDOA014422.
DR GeneID; 101894200; -.
DR KEGG; mde:101894200; -.
DR VEuPathDB; VectorBase:MDOA014422; -.
DR OrthoDB; 1120702at2759; -.
DR BRENDA; 3.4.23.5; 3486.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.1960; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF51; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 2.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 2: Evidence at transcript level;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454,
KW ECO:0000313|RefSeq:NP_001273807.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001273807.1}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..390
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001273807.1"
FT /id="PRO_5038206371"
FT DOMAIN 71..387
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 89
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 275
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 102..109
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 309..346
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 390 AA; 42426 MW; 6CCDA8BE89DE9CBF CRC64;
MIKFVILLSL VSLLLPESFA EEKLIRVPIQ KIKSARKHFY EVGTELQQLR LTYGAGGVTP
EPLSNYLDAQ YYGPISIGTP PQDFKVVFDT GSSNLWVPSK KCHLTNIACL MHNKYDATKS
KTFKQNGTEF AIHYGSGSLS GYLSTDTVNI GGLDIKDQTF AEALSEPGLV FVAAKFDGIL
GLGYSSISVD GVKPPFYAMY EQGLISQPIF SFYLNRDPKA PEGGEIIFGG SDPDHYTGDF
TYLPVTRKAY WQIKMDSASM GDLKCAKGGC QVIADTGTSL IALPPSEATS INQAIGGTPI
MGGQYMVACE DIPKLPVIKF VLGGKTFELE GKDYVLRIAQ MGKTICLSGF MGIDIPPPNG
PLWILGDVFI GKYYTEFDMG NDRVGFAIAK
//
