ID A2Q4E5_MEDTR Unreviewed; 853 AA.
AC A2Q4E5;
DT 06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Disease resistance protein {ECO:0000313|EMBL:ABN08495.1, ECO:0000313|EMBL:AES80234.1};
DE SubName: Full=Putative P-loop containing nucleoside triphosphate hydrolase, leucine-rich repeat domain, L {ECO:0000313|EMBL:RHN47001.1};
GN Name=11431674 {ECO:0000313|EnsemblPlants:AES80234};
GN OrderedLocusNames=MTR_7g078300 {ECO:0000313|EMBL:AES80234.1};
GN ORFNames=MtrDRAFT_AC157473g10v2 {ECO:0000313|EMBL:ABN08495.1},
GN MtrunA17_Chr7g0248221 {ECO:0000313|EMBL:RHN47001.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:ABN08495.1};
RN [1] {ECO:0000313|EMBL:ABN08495.1}
RP NUCLEOTIDE SEQUENCE.
RA Town C.D.;
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABN08495.1}
RP NUCLEOTIDE SEQUENCE.
RG The International Medicago Genome Annotation Group;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AES80234.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AES80234.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES80234,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [4] {ECO:0000313|EMBL:AES80234.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES80234,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [5] {ECO:0000313|EnsemblPlants:AES80234}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES80234};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
RN [6] {ECO:0000313|Proteomes:UP000265566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Jemalong A17 {ECO:0000313|Proteomes:UP000265566};
RX PubMed=30397259; DOI=10.1038/s41477-018-0286-7;
RA Pecrix Y., Staton S.E., Sallet E., Lelandais-Briere C., Moreau S.,
RA Carrere S., Blein T., Jardinaud M.F., Latrasse D., Zouine M., Zahm M.,
RA Kreplak J., Mayjonade B., Satge C., Perez M., Cauet S., Marande W.,
RA Chantry-Darmon C., Lopez-Roques C., Bouchez O., Berard A., Debelle F.,
RA Munos S., Bendahmane A., Berges H., Niebel A., Buitink J., Frugier F.,
RA Benhamed M., Crespi M., Gouzy J., Gamas P.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 4:1017-1025(2018).
RN [7] {ECO:0000313|EMBL:RHN47001.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:RHN47001.1};
RA Pecrix Y., Gamas P., Carrere S.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 0:0-0(2018).
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DR EMBL; AC157473; ABN08495.1; -; Genomic_DNA.
DR EMBL; CM001223; AES80234.1; -; Genomic_DNA.
DR EMBL; PSQE01000007; RHN47001.1; -; Genomic_DNA.
DR RefSeq; XP_003624016.1; XM_003623968.1.
DR AlphaFoldDB; A2Q4E5; -.
DR PaxDb; 3880-AES80234; -.
DR EnsemblPlants; AES80234; AES80234; MTR_7g078300.
DR GeneID; 11431674; -.
DR Gramene; AES80234; AES80234; MTR_7g078300.
DR KEGG; mtr:11431674; -.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000837_8_1_1; -.
DR OMA; EWESIRE; -.
DR OrthoDB; 889688at2759; -.
DR Proteomes; UP000002051; Chromosome 7.
DR Proteomes; UP000265566; Chromosome 7.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:InterPro.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039203; RGA2/3-like.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR36766:SF38; NB-ARC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR36766; PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000313|EMBL:RHN47001.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 11..96
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 171..422
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 853 AA; 97373 MW; 38386341B72DC59C CRC64;
MAESFLFSLA ESFITKVASR AVEEASLALG VYDDLREIKN TVSLIKAVLL DAELKQKQNH
ELREWLQQIK RVFYDAEDVI NDFECEALRK HVVNTSGSIR RKVRRYLSSS NPLVYRLKMA
HQIKHINKRL NKNAAARHNF GLQINDSDNH VVKRRELTHS HVVDSDVIGR DYDKQKIIDL
LLQDSGHKSL SVIPIVGIGG LGKTTLAKTV FNDKSLDETF PLKMWVCVSD DFELQHLLIK
ILNSASVSDA TPNLIHEENI KNLDVQQLQT HLRNTLAGKK FLLVLDDVWS EDRVKWIEVK
NLLQVGDEGS KVLVTTRSHS IAKMMCTNTS YTLQGLSRED SLSVFVKWAF KEGEEKKYPK
LIEIGKEIVQ KCGGLPLALR TLGSLLFLKD DIEEWKFVRD NEIWNLPQKE DDILPAIKLS
FDQLPSYLKR CFACFSLFEK DFKFVTYTVT VLWEALDFLP SPNKGKTLED VGNQFLHELQ
SRSFLQDFYV SGNVCVFKLH DLVHDLALYV ARDEFQLLKL HNENIIKNVL HLSFTTNDLL
GQTPIPAGLR TILFPLEANN VAFLNNLASR CKFLRVLRLT HSTYESLPRS IGKLKHLRYL
NLKGNKELKS LPDSVCKLQN LQTLILEGCL KLEKLPNGIG NLISLRQLHI TTMQSSFPDK
EIAKLTYLEF LSICSCDNLE SLLGELELPN LKSLSIIYCG NITSLPLQLI PNVDSLMISN
CNKLKLSLGH ENAIPKLRLK LLYIESLPEL LSFPQWLQGC ADTLHSLFIG HCENLEKLPE
WSSTFICLNT LTIRNCPKLL SLPDDVHCLP NLECLEMKDC PELCKRYQPK VGHDWPKISH
IKRVNIKSSE HEN
//