ID   A2SHN6_METPP            Unreviewed;       921 AA.
AC   A2SHN6;
DT   06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2007, sequence version 1.
DT   27-MAR-2024, entry version 84.
DE   SubName: Full=Putative zinc protease {ECO:0000313|EMBL:ABM95075.1};
GN   OrderedLocusNames=Mpe_A2119 {ECO:0000313|EMBL:ABM95075.1};
OS   Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Sphaerotilaceae; Methylibium.
OX   NCBI_TaxID=420662 {ECO:0000313|EMBL:ABM95075.1, ECO:0000313|Proteomes:UP000000366};
RN   [1] {ECO:0000313|EMBL:ABM95075.1, ECO:0000313|Proteomes:UP000000366}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1232 / LMG 22953 / PM1
RC   {ECO:0000313|Proteomes:UP000000366};
RX   PubMed=17158667; DOI=10.1128/JB.01259-06;
RA   Kane S.R., Chakicherla A.Y., Chain P.S.G., Schmidt R., Shin M.W.,
RA   Legler T.C., Scow K.M., Larimer F.W., Lucas S.M., Richardson P.M.,
RA   Hristova K.R.;
RT   "Whole-genome analysis of the methyl tert-butyl ether-degrading beta-
RT   proteobacterium Methylibium petroleiphilum PM1.";
RL   J. Bacteriol. 189:1931-1945(2007).
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR   EMBL; CP000555; ABM95075.1; -; Genomic_DNA.
DR   AlphaFoldDB; A2SHN6; -.
DR   STRING; 420662.Mpe_A2119; -.
DR   KEGG; mpt:Mpe_A2119; -.
DR   eggNOG; COG0612; Bacteria.
DR   HOGENOM; CLU_007487_1_1_4; -.
DR   Proteomes; UP000000366; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   PANTHER; PTHR43690:SF21; PROCESSING PROTEASE; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:ABM95075.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000366};
KW   Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..921
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002645470"
FT   DOMAIN          64..209
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          217..392
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          673..852
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   921 AA;  100701 MW;  EFEC16929341EA0D CRC64;
     MFSKYLVAGA LALVVMQVSP VVAAASKPIP PSGSVASPGL PRGVTAVTQV EGITEYRLTN
     GLQVLLVPDA SKPTTTVNLT YHVGSRHENY GETGMAHLLE HLMFKGTPTT PNVWGEFTKR
     GLRANGSTWF DRTNYFASFA ANDDNLRWFL SWHADAMVHS FIARKDLDSE MTVVRNEMEM
     GENNPGRILY QKTLAAMYDW HNYGKDTIGA RSDVENVDIA RLQAFYRQYY QPDNATLVVS
     GQFDTARVLA WVQQYFGKIP RPRRVLPTLY TLDAAQDGER ALTLRRVGGA PLLYAGYHVP
     AAPDPEFAAI ELLALVLGDA PSGRLHKRLV EKQLAASVGA EPFGLHDPGA ALFVAQLAPE
     QDVERARSEL IAVLESVAAE PVTAEELERA RAKWLKGWDL AFTNPETVGV SLSESVAQGD
     WRLFFLIRDR VKATTLEDVQ RVAVERLLPS NRTLATYVPT DKPQRAPAPK AVDVAAQFKD
     FKPQAGATAV AAFDTTPANI DAQTQRFALA SGMKVALLPK PTRGGAVNAV LSLHFGDEKS
     LADQGEVPAL TAAMLDEGTA KLSRQQIRDR LDALQAEVAF SSGTGSVSAT IATKRENLPA
     VIALVGELLR EPSFPPAVLE EQRSQALTGV EQQRKEPEAV VANAIDRHVN RYPRSDVRHA
     KSFDELVADI RAATPDQLRA FHRRFYGASH AEFGASGDLD VPAVRQALEA AFGDWKSSEP
     YARVSDPLAP VAPARLVLPT PDKQNAHMAV FLPVPLMDSD PDYAPLTLAN HLLGGGGSSR
     LWVRIREKEG LSYGVYSYLA WNQDERNSPW QAQAIFAPQN RAKVEAAFRE EVARSLQDGF
     TATELQEAQR GLISARRLSR AQDARLAAGL ASNLRLDRTF AISQQVDDAI AAATLEQVNA
     ALRKYIRPEA FVYGFGGDFK E
//