ID A2SLN8_METPP Unreviewed; 506 AA.
AC A2SLN8;
DT 06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE RecName: Full=methylmalonate-semialdehyde dehydrogenase (CoA acylating) {ECO:0000256|ARBA:ARBA00013048};
DE EC=1.2.1.27 {ECO:0000256|ARBA:ARBA00013048};
GN OrderedLocusNames=Mpe_A3524 {ECO:0000313|EMBL:ABM96477.1};
OS Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Methylibium.
OX NCBI_TaxID=420662 {ECO:0000313|EMBL:ABM96477.1, ECO:0000313|Proteomes:UP000000366};
RN [1] {ECO:0000313|EMBL:ABM96477.1, ECO:0000313|Proteomes:UP000000366}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1232 / LMG 22953 / PM1
RC {ECO:0000313|Proteomes:UP000000366};
RX PubMed=17158667; DOI=10.1128/JB.01259-06;
RA Kane S.R., Chakicherla A.Y., Chain P.S.G., Schmidt R., Shin M.W.,
RA Legler T.C., Scow K.M., Larimer F.W., Lucas S.M., Richardson P.M.,
RA Hristova K.R.;
RT "Whole-genome analysis of the methyl tert-butyl ether-degrading beta-
RT proteobacterium Methylibium petroleiphilum PM1.";
RL J. Bacteriol. 189:1931-1945(2007).
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DR EMBL; CP000555; ABM96477.1; -; Genomic_DNA.
DR RefSeq; WP_011831097.1; NC_008825.1.
DR AlphaFoldDB; A2SLN8; -.
DR STRING; 420662.Mpe_A3524; -.
DR KEGG; mpt:Mpe_A3524; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_1_10_4; -.
DR Proteomes; UP000000366; Chromosome.
DR GO; GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity; IEA:UniProtKB-EC.
DR CDD; cd07085; ALDH_F6_MMSDH; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR010061; MeMal-semiAld_DH.
DR NCBIfam; TIGR01722; MMSDH; 1.
DR PANTHER; PTHR43866; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43866:SF4; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ABM96477.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000366}.
FT DOMAIN 24..486
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
SQ SEQUENCE 506 AA; 54116 MW; 77DCF77254BF52D0 CRC64;
MGAPEAFTAT AEIGHFIGGR AVPSTSGRRQ AVYNPATGAV ARQVALASAD EVNAAVAAAQ
AAFPAWADTP PLRRARVLNK FLQLLNEQRD TLAAMITAEH GKVFTDAQGE VTRGIEIVEF
ACGAPQLLKT DFTDQVGTGI DNWVLRQPLG VVAGITPFNF PVMVPMWMFP MAIATGNSFV
LKPSERDPSP SLFIAELLKQ AGLPDGVFNV VQGDKLAVDT LLTHPDVKAV SFVGSTPIAQ
YIYETGAKHG KRVQALGGAK NHMVVMPDAD LEQSVDALIG AAYGSAGERC MAISVAVLVG
DVADQIVPKL AERAKALKVK NGMELDAEMG PIVTPQALER IEGYIAHGVD EGAKLVVDGR
GLKVPGHEQG FFTGGTLFDH VTPEMKIYKE EIFGPVLACV RVPDFASAVA LVNAHEFGNG
VACFTRDGHV AREFSRRIQV GMVGINVPIP VPMAWHGFGG WKKSLFGDMH AYGEEGVRFY
TKQKSVMQRW PESTPKGAEF VMPTSK
//
