ID A2SM85_METPP Unreviewed; 569 AA.
AC A2SM85;
DT 06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Putative membrane-fusion protein {ECO:0000313|EMBL:ABM96674.1};
GN OrderedLocusNames=Mpe_A3721 {ECO:0000313|EMBL:ABM96674.1};
OS Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Methylibium.
OX NCBI_TaxID=420662 {ECO:0000313|EMBL:ABM96674.1, ECO:0000313|Proteomes:UP000000366};
RN [1] {ECO:0000313|EMBL:ABM96674.1, ECO:0000313|Proteomes:UP000000366}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1232 / LMG 22953 / PM1
RC {ECO:0000313|Proteomes:UP000000366};
RX PubMed=17158667; DOI=10.1128/JB.01259-06;
RA Kane S.R., Chakicherla A.Y., Chain P.S.G., Schmidt R., Shin M.W.,
RA Legler T.C., Scow K.M., Larimer F.W., Lucas S.M., Richardson P.M.,
RA Hristova K.R.;
RT "Whole-genome analysis of the methyl tert-butyl ether-degrading beta-
RT proteobacterium Methylibium petroleiphilum PM1.";
RL J. Bacteriol. 189:1931-1945(2007).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; CP000555; ABM96674.1; -; Genomic_DNA.
DR RefSeq; WP_011831294.1; NC_008825.1.
DR AlphaFoldDB; A2SM85; -.
DR STRING; 420662.Mpe_A3721; -.
DR KEGG; mpt:Mpe_A3721; -.
DR eggNOG; COG0845; Bacteria.
DR HOGENOM; CLU_018816_14_1_4; -.
DR Proteomes; UP000000366; Chromosome.
DR GO; GO:0019898; C:extrinsic component of membrane; IEA:InterPro.
DR GO; GO:1990195; C:macrolide transmembrane transporter complex; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 6.10.140.1990; -; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR030190; MacA_alpha-hairpin_sf.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000366};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..310
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 331..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 162..196
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 364..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 569 AA; 59788 MW; 9CC779D2F74B7BBA CRC64;
MTAPPDTASR PRWRRLLAHR ALWAVIALLL IVGGGYAAWR LFYGQPNLRE QYQFATVQRA
DIQDLVTATG TVQPRDYVDV GAQVSGQLKR LHVEVGSIVK AGDLLAEIDP TVLTATVDAR
RAGLRNQRAT LAERESQYAL AQLLLTRQRN LMKDDATTTE SLQQAEATAK AAKAQIDAIK
ASIEQTESTL RADEANLNYA KIYAPLAGTV VSVTARQGQT LNANQSAPTI LRIADLSTMT
VQTQVSEADV SKLRQDMTVY FTTLGSQGRR WYGTLRKVEP TPTVTNNVVL YNALFDVPNN
NQALMTNMTA QVFFIAAEAK DALVVPVAAI GSTGSGRTGG GRRERGEPER AASAPAEGAS
APAASASPPT TSAGAASVPA RRSSSSAAPA AAPAGTGAAA PRSGAPLPER FAGMSREERR
AAFEAMSPEE RQALREQRLA AGDDRLHRGE NARAPATARA ASATAAASGP TIPATGGFAT
VERPRGTRRS TVKVLTPAGT LEERSVELGV SNRVQVQVLS GLSEGDQVVA GIKQPQQAQA
PRSAGAQGGG LQQGPAGMPP GMGQAPRGR
//
