ID A2SPF6_METLZ Unreviewed; 297 AA.
AC A2SPF6;
DT 06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Methionine synthase (B12-independent) {ECO:0000313|EMBL:ABN06212.1};
DE EC=2.1.1.14 {ECO:0000313|EMBL:ABN06212.1};
GN OrderedLocusNames=Mlab_0034 {ECO:0000313|EMBL:ABN06212.1};
OS Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanocorpusculaceae; Methanocorpusculum.
OX NCBI_TaxID=410358 {ECO:0000313|EMBL:ABN06212.1, ECO:0000313|Proteomes:UP000000365};
RN [1] {ECO:0000313|EMBL:ABN06212.1, ECO:0000313|Proteomes:UP000000365}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43576 / DSM 4855 / Z {ECO:0000313|Proteomes:UP000000365};
RX PubMed=21304657; DOI=10.4056.sigs.35575;
RA Anderson I.J., Sieprawska-Lupa M., Goltsman E., Lapidus A., Copeland A.,
RA Glavina Del Rio T., Tice H., Dalin E., Barry K., Pitluck S., Hauser L.,
RA Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C.;
RT "Complete genome sequence of Methanocorpusculum labreanum type strain Z.";
RL Stand. Genomic Sci. 1:197-203(2009).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR EMBL; CP000559; ABN06212.1; -; Genomic_DNA.
DR RefSeq; WP_011832413.1; NC_008942.1.
DR AlphaFoldDB; A2SPF6; -.
DR STRING; 410358.Mlab_0034; -.
DR GeneID; 4796181; -.
DR KEGG; mla:Mlab_0034; -.
DR eggNOG; arCOG01876; Archaea.
DR HOGENOM; CLU_040013_3_2_2; -.
DR OrthoDB; 17656at2157; -.
DR Proteomes; UP000000365; Chromosome.
DR GO; GO:0003871; F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd03311; CIMS_C_terminal_like; 1.
DR Gene3D; 3.20.20.210; -; 1.
DR InterPro; IPR002629; Met_Synth_C/arc.
DR InterPro; IPR038071; UROD/MetE-like_sf.
DR PANTHER; PTHR30519; 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE; 1.
DR PANTHER; PTHR30519:SF0; 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE; 1.
DR Pfam; PF01717; Meth_synt_2; 1.
DR SUPFAM; SSF51726; UROD/MetE-like; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000313|EMBL:ABN06212.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000365};
KW Transferase {ECO:0000313|EMBL:ABN06212.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 7..291
FT /note="Cobalamin-independent methionine synthase MetE C-
FT terminal/archaeal"
FT /evidence="ECO:0000259|Pfam:PF01717"
SQ SEQUENCE 297 AA; 31976 MW; 6AF810DC1F27EF42 CRC64;
MDLPCIMPTT VVGSFPCVKG TGISSLIDPY KKAVQFAVAE QIRAGVDIIS DGQVRADMVQ
AFVSKLPGIS DKTVLGKIGA ADKPITVGDT KYALTKTKYV KGILTGPCTL AYALHVDTPI
YRNKEEVVMD LAAALHQEAK YLAETGVAII QVDEPILSTG AISVDTAREA LKIIFAGIKT
PSCIHTCGML GEIADSWTKL PVDILDFEYA VSMENLSVLS KRDLAGKKIG CGCVKSSDPH
IESVKEIEER ITACVDAFGA ENILIDPDCG LRMHTPETAF EKLARMCEAT KNVRERL
//
