ID A2SPV2_METLZ Unreviewed; 529 AA.
AC A2SPV2;
DT 06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Xanthine/uracil/vitamin C permease {ECO:0000313|EMBL:ABN06358.1};
GN OrderedLocusNames=Mlab_0182 {ECO:0000313|EMBL:ABN06358.1};
OS Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanocorpusculaceae; Methanocorpusculum.
OX NCBI_TaxID=410358 {ECO:0000313|EMBL:ABN06358.1, ECO:0000313|Proteomes:UP000000365};
RN [1] {ECO:0000313|EMBL:ABN06358.1, ECO:0000313|Proteomes:UP000000365}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43576 / DSM 4855 / Z {ECO:0000313|Proteomes:UP000000365};
RX PubMed=21304657; DOI=10.4056.sigs.35575;
RA Anderson I.J., Sieprawska-Lupa M., Goltsman E., Lapidus A., Copeland A.,
RA Glavina Del Rio T., Tice H., Dalin E., Barry K., Pitluck S., Hauser L.,
RA Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C.;
RT "Complete genome sequence of Methanocorpusculum labreanum type strain Z.";
RL Stand. Genomic Sci. 1:197-203(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR EMBL; CP000559; ABN06358.1; -; Genomic_DNA.
DR AlphaFoldDB; A2SPV2; -.
DR STRING; 410358.Mlab_0182; -.
DR TCDB; 2.A.40.2.2; the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.
DR KEGG; mla:Mlab_0182; -.
DR eggNOG; arCOG02805; Archaea.
DR HOGENOM; CLU_017959_8_3_2; -.
DR Proteomes; UP000000365; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR NCBIfam; NF037981; NCS2_1; 1.
DR PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR PANTHER; PTHR42810:SF2; PURINE PERMEASE C1399.01C-RELATED; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000365};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 406..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 529 AA; 56802 MW; 982C87FCEDD33020 CRC64;
MFTMAEGDEP IYNVKDNVPL GTTVLTILQH FFVLAVYMTY PVIISNAIGG STDLTMFLIS
ATLIGSGIAT ILQSFSKTGA GYLLPMVPNS SYLPASLLAA TAGGLPLLYG MLIISGLFEM
VISRFTTFFR IVFPNEVTGV VLFLLGIAIV PFAFPLFFGS TDSGPLDPAS TVVGIITLTS
TILLSVIPKR FFKFYAILIG IVIGMAASVF LGVFKLETLL QITSLSVFWI PNPIGIVSYS
FEFALLIPFA IAMICVMLKS VGNISLLNAY TKEGEKNTLK NGLMSEGAGV AIAGALGGIG
IGSSSGATGL VVGTGIAAKR VGLGLGIFLI LCGFLPAIGW VFHILPKPIL GATLLYAVTF
VMVTGIQSIS SRMLDPRRKF VVILPILIGV SSAVCPYLYA DLPKTLALFF ASPLTSGSMA
VLILGLLLRI GIKKHRSFDF SKDANLQRFL MECGRQWTLE RMQMLSISNH LQNLADAGEP
ERLEMKFEPI GMLRAEMVFK EPVENVPKMK INGNLEADGR VVKASYPLM
//
