ID A2SW27_GECLA Unreviewed; 603 AA.
AC A2SW27;
DT 06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2007, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE RecName: Full=Guanylate cyclase soluble subunit beta-1 {ECO:0000256|ARBA:ARBA00039698};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
DE AltName: Full=Guanylate cyclase soluble subunit beta-3 {ECO:0000256|ARBA:ARBA00041698};
DE AltName: Full=Soluble guanylate cyclase small subunit {ECO:0000256|ARBA:ARBA00043208};
OS Gecarcinus lateralis (Blackback land crab).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura;
OC Eubrachyura; Grapsoidea; Gecarcinidae; Gecarcinus.
OX NCBI_TaxID=6769 {ECO:0000313|EMBL:ABC94528.1};
RN [1] {ECO:0000313|EMBL:ABC94528.1}
RP NUCLEOTIDE SEQUENCE.
RA Lee S.G., Kim H.-W., Mykles D.L.;
RT "Guanylyl cyclases in the tropical land crab, Gecarcinus lateralis: cloning
RT of soluble (NO-sensitive and -insensitive) and membrane receptor forms.";
RL Comp. Biochem. Physiol. 2D:332-344(2007).
CC -!- FUNCTION: Mediates responses to nitric oxide (NO) by catalyzing the
CC biosynthesis of the signaling molecule cGMP.
CC {ECO:0000256|ARBA:ARBA00037442}.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; DQ355433; ABC94528.1; -; mRNA.
DR AlphaFoldDB; A2SW27; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR038158; H-NOX_domain_sf.
DR InterPro; IPR011644; Heme_NO-bd.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655:SF2; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1; 1.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07700; HNOB; 1.
DR Pfam; PF07701; HNOBA; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134}.
FT DOMAIN 414..547
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 359..386
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 603 AA; 68488 MW; A5E2E61F4391358D CRC64;
MYGFVNYAIE QLVVRNFGDE TWEDIKREAE VHMDGSILVR LTYEDEITYN IVAAAERVLG
VPANAILELF GKMFFKFCQE SGYDTILQVL GATVSDFLQN LDALHDHLAL IYPGMKAPSF
RCTERAEDGA LILHYYSDRP GLEYIVIGIV KAVSKELHET EVEVEILKTK EQEGHVQFLI
TEKDTHTTHH ISETTHDLEA DTESKISPKT FCQVCPFHLM FDRDLHVHQA GVSISRVLPS
VTYPDASLDR LFQVVRPHME LTFENILSHI NTIYVLRTRE GLAQATRDEP GPDQGCLRLK
GQMIYLPETD LMLYVCSPSV LNLDDLYRRG LYLSDIPLHD ATRDLVLLSE KFEAEYTLTT
NLEILNDKLQ QTHRELESER QKTDKLLYSV LPISIANELR HKRPVPPRRY EVVTLLFSGI
VGFTDYCSRH TDIAGASKIV RMLNDLYTAF DVPTDEVKNP NVYKVETVGD KYMAVSGLPE
ACDHHARCIG NLALDMMDKA AGVIVDGQRV QITIGIHTGE VVTGVIGQRM PRYCLFGNTV
NITSRTETTG EKGRINVSEV SYRYLQQQEN QDSGFAFTYR GPVPMKGRKE PMQVWFLSRR
RAA
//
