ID A2VCZ4_XENTR Unreviewed; 349 AA.
AC A2VCZ4;
DT 20-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 20-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=Endophilin-A1 {ECO:0000313|RefSeq:NP_001090766.1};
DE SubName: Full=LOC100037852 protein {ECO:0000313|EMBL:AAI29027.1};
DE SubName: Full=SH3-domain GRB2-like 2 {ECO:0000313|Ensembl:ENSXETP00000089584};
GN Name=sh3gl2 {ECO:0000313|Ensembl:ENSXETP00000089584,
GN ECO:0000313|RefSeq:NP_001090766.1,
GN ECO:0000313|Xenbase:XB-GENE-1012090};
GN Synonyms=LOC100037852 {ECO:0000313|EMBL:AAI29027.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI29027.1};
RN [1] {ECO:0000313|RefSeq:NP_001090766.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI29027.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000313|EMBL:AAI29027.1}, and Whole embryo
RC {ECO:0000313|EMBL:AAI35562.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000089584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000089584};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000089584}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2020) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001090766.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the endophilin family.
CC {ECO:0000256|ARBA:ARBA00006697}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC129026; AAI29027.1; -; mRNA.
DR EMBL; BC135561; AAI35562.1; -; mRNA.
DR RefSeq; NP_001090766.1; NM_001097297.1.
DR DNASU; 100037852; -.
DR Ensembl; ENSXETT00000071209; ENSXETP00000089584; ENSXETG00000039551.
DR GeneID; 100037852; -.
DR KEGG; xtr:100037852; -.
DR AGR; Xenbase:XB-GENE-1012090; -.
DR CTD; 6456; -.
DR Xenbase; XB-GENE-1012090; sh3gl2.
DR OMA; NLLEMDX; -.
DR OrthoDB; 25371at2759; -.
DR Reactome; R-XTR-182971; EGFR downregulation.
DR Reactome; R-XTR-2132295; MHC class II antigen presentation.
DR Reactome; R-XTR-432720; Lysosome Vesicle Biogenesis.
DR Reactome; R-XTR-432722; Golgi Associated Vesicle Biogenesis.
DR Reactome; R-XTR-437239; Recycling pathway of L1.
DR Reactome; R-XTR-6807004; Negative regulation of MET activity.
DR Reactome; R-XTR-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-XTR-8856828; Clathrin-mediated endocytosis.
DR Proteomes; UP000008143; Chromosome 1.
DR Bgee; ENSXETG00000039551; Expressed in brain and 10 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd07613; BAR_Endophilin_A1; 1.
DR CDD; cd11803; SH3_Endophilin_A; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR035824; Endophilin_A_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14167:SF50; ENDOPHILIN-A1; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 18..249
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 287..346
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
SQ SEQUENCE 349 AA; 39576 MW; 30BFA3412A996E13 CRC64;
MSVAGLKKQF HKATQKVSEK VGGAEGTKLD EDFKEMERKV DVTSRAVMEI MTKTTEYLQP
NPASRAKLSM LNTMSKIRGQ EKGPGYPQAE ALLAEAMFKF GREIGDESNF GLALIDVGDA
MRELSDIKDC LDIDVKQNFI DPLQNLHDKD LREIQHHLKK LEGRRLDFDY KKKRQGKITD
DEIRQALEKF DESKEIAESS MFNLLEMDIE QVSQLSALAQ AQLEYHRQAS QILQQVAVKL
EQRIREASSQ PRREYQPKPR MSLELENSQL NGGIALAGTP KPSGAPMDQP CCRALYDFDP
ENEGELGFKE GDIITLTNQI DENWYEGMLH GQSGFFPINY VDILVPLPH
//
