ID SF3A1_BOVIN Reviewed; 793 AA.
AC A2VDN6;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 03-APR-2013, entry version 45.
DE RecName: Full=Splicing factor 3A subunit 1;
GN Name=SF3A1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC Pecora; Bovidae; Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Basal ganglia;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Subunit of the splicing factor SF3A required for 'A'
CC complex assembly formed by the stable binding of U2 snRNP to the
CC branchpoint sequence (BPS) in pre-mRNA. Sequence independent
CC binding of SF3A/SF3B complex upstream of the branch site is
CC essential, it may anchor U2 snRNP to the pre-mRNA. May also be
CC involved in the assembly of the 'E' complex (By similarity).
CC -!- SUBUNIT: Identified in the spliceosome C complex (By similarity).
CC Component of splicing factor SF3A which is composed of three
CC subunits; SF3A3/SAP61, SF3A2/SAP62, SF3A1/SAP114. SF3A associates
CC with the splicing factor SF3B and a 12S RNA unit to form the U2
CC small nuclear ribonucleoproteins complex (U2 snRNP). Interacts
CC with SF3A3 (By similarity).
CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC -!- SIMILARITY: Contains 2 SURP motif repeats.
CC -!- SIMILARITY: Contains 1 ubiquitin-like domain.
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DR EMBL; BC133328; AAI33329.1; -; mRNA.
DR IPI; IPI00687512; -.
DR RefSeq; NP_001074979.1; NM_001081510.1.
DR UniGene; Bt.7260; -.
DR ProteinModelPortal; A2VDN6; -.
DR SMR; A2VDN6; 48-110, 134-217, 704-789.
DR STRING; 9913.ENSBTAP00000004398; -.
DR PaxDb; A2VDN6; -.
DR PRIDE; A2VDN6; -.
DR Ensembl; ENSBTAT00000004398; ENSBTAP00000004398; ENSBTAG00000003390.
DR GeneID; 504381; -.
DR KEGG; bta:504381; -.
DR CTD; 10291; -.
DR eggNOG; NOG300902; -.
DR GeneTree; ENSGT00570000079144; -.
DR HOGENOM; HOG000238941; -.
DR HOVERGEN; HBG059993; -.
DR InParanoid; A2VDN6; -.
DR KO; K12825; -.
DR OMA; GMPPAKQ; -.
DR OrthoDB; EOG4N5VWN; -.
DR NextBio; 20866634; -.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IEA:Compara.
DR GO; GO:0005684; C:U2-type spliceosomal complex; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR InterPro; IPR022030; PRP21-like.
DR InterPro; IPR000061; Surp.
DR InterPro; IPR000626; Ubiquitin.
DR InterPro; IPR019955; Ubiquitin_supergroup.
DR Pfam; PF12230; PRP21_like_P; 1.
DR Pfam; PF01805; Surp; 2.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00648; SWAP; 2.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF109905; SSF109905; 2.
DR PROSITE; PS50128; SURP; 2.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Complete proteome; mRNA processing; mRNA splicing;
KW Nucleus; Phosphoprotein; Reference proteome; Repeat; Spliceosome.
FT CHAIN 1 793 Splicing factor 3A subunit 1.
FT /FTId=PRO_0000295296.
FT REPEAT 52 94 SURP motif 1.
FT REPEAT 166 208 SURP motif 2.
FT DOMAIN 707 793 Ubiquitin-like.
FT COMPBIAS 118 122 Poly-Gln.
FT COMPBIAS 260 267 Poly-Glu.
FT COMPBIAS 369 372 Poly-Pro.
FT COMPBIAS 557 560 Poly-Pro.
FT COMPBIAS 672 675 Poly-Pro.
FT MOD_RES 55 55 N6-acetyllysine (By similarity).
FT MOD_RES 320 320 Phosphoserine (By similarity).
FT MOD_RES 329 329 Phosphoserine (By similarity).
FT MOD_RES 359 359 Phosphoserine (By similarity).
FT MOD_RES 413 413 Phosphoserine (By similarity).
FT MOD_RES 451 451 Phosphoserine (By similarity).
FT MOD_RES 456 456 Phosphotyrosine (By similarity).
FT MOD_RES 759 759 Phosphotyrosine (By similarity).
SQ SEQUENCE 793 AA; 88786 MW; 6FA0AD2E622056FD CRC64;
MPAGPVQAVP PPPPAATEPK QPTEEEASSK EDSTPSKPVV GIIYPPPEVR NIVDKTASFV
ARNGPEFEAR IRQNEINNPK FNFLNPNDPY HAYYRHKVSE FKEGKAQEPS AAIPKVMQQQ
QQASQQQLPQ KVQAQVIQET IVPKEPPPEF EFIADPPSIS AFDLDVVKLT AQFVARNGRQ
FLTQLMQKEQ RNYQFDFLRP QHSLFNYFTK LVEQYTKILI PPKGLFTKLK KEAENPREVL
DQVCYRVEWA KFQERERKKE EEEKEKERVA YAQIDWHDFV VVETVDFQPN EQGNFPPPTT
PEELGARILI QERYEKFGES EEVEMEVESD EEDEKQEKAE EPPSQLDQDT QVQDMDEGSD
DEEEGQKVPP PPETPMPPPL PPTPDQVIVR KDYDPKASKP LPPAPAPDEY LVSPITGEKI
PASKMQEHMR IGLLDPRWLE QRDRSIREKQ SDDEVYAPGL DIESSLKQLA ERRTDIFGVE
ETAIGKKIGE EEIQKPEEKV TWDGHSGSMA RTQQAAQANI TLQEQIEAIH KAKGLVPEDD
TKEKIGPSKP NEIPQQPPPP SSATNIPSSA PPITSVPRPP AMPPPVRTTV VSAVPVMPRP
PMASVVRLPP GSVIAPMPPI IHAPRINVVP MPPSAPPIMA PRPPPMIVPT AFVPAPPVAP
VPAPAPMPPV HPPPPMEDEP ASKKLKTEDS LMPEEEFLRR NKGPVSIKVQ VPNMQDKTEW
KLNGQVLVFT LPLTDQVSVI KVKIHEATGM PAGKQKLQYE GIFIKDSNSL AYYNMANGAV
IHLALKERGG RKK
//
