ID A2W1T8_9BURK Unreviewed; 306 AA.
AC A2W1T8;
DT 20-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 20-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Ureidoglycolate lyase {ECO:0000256|ARBA:ARBA00019751};
DE EC=4.3.2.3 {ECO:0000256|ARBA:ARBA00012341};
DE AltName: Full=Ureidoglycolase {ECO:0000256|ARBA:ARBA00032843};
DE AltName: Full=Ureidoglycolatase {ECO:0000256|ARBA:ARBA00030302};
DE AltName: Full=Ureidoglycolate hydrolase {ECO:0000256|ARBA:ARBA00029968};
GN ORFNames=BCPG_04307 {ECO:0000313|EMBL:EAY65934.1};
OS Burkholderia cenocepacia PC184.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=350702 {ECO:0000313|EMBL:EAY65934.1, ECO:0000313|Proteomes:UP000053735};
RN [1] {ECO:0000313|EMBL:EAY65934.1, ECO:0000313|Proteomes:UP000053735}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PC184 {ECO:0000313|EMBL:EAY65934.1,
RC ECO:0000313|Proteomes:UP000053735};
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Devon K., Nusbaum C., Borowsky M.L.,
RA Jaffe D., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M.,
RA Mauceli E., Brockman W., Young S., LaButti K., DeCaprio D., Crawford M.,
RA Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., White J.,
RA Larson L., Alvarado L., Kodira C., Zeng Q., Yandava C., Oleary S.,
RA LiPuma J., Lory S.;
RT "The Genome Sequence of Burkholderia cenocepacia (strain PC184).";
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-ureidoglycolate = glyoxylate + urea; Xref=Rhea:RHEA:11304,
CC ChEBI:CHEBI:16199, ChEBI:CHEBI:36655, ChEBI:CHEBI:57296; EC=4.3.2.3;
CC Evidence={ECO:0000256|ARBA:ARBA00001281};
CC -!- PATHWAY: Purine metabolism; urate degradation.
CC {ECO:0000256|ARBA:ARBA00004705}.
CC -!- SIMILARITY: Belongs to the FAH family. {ECO:0000256|ARBA:ARBA00010211}.
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DR EMBL; CH482378; EAY65934.1; -; Genomic_DNA.
DR AlphaFoldDB; A2W1T8; -.
DR HOGENOM; CLU_028458_3_1_4; -.
DR UniPathway; UPA00394; -.
DR Proteomes; UP000053735; Unassembled WGS sequence.
DR GO; GO:0050385; F:ureidoglycolate lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0019628; P:urate catabolic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.90.850.10; Fumarylacetoacetase-like, C-terminal domain; 1.
DR InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR PANTHER; PTHR42796:SF4; FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A; 1.
DR PANTHER; PTHR42796; FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A-RELATED; 1.
DR Pfam; PF01557; FAA_hydrolase; 1.
DR SUPFAM; SSF56529; FAH; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239}.
FT DOMAIN 91..296
FT /note="Fumarylacetoacetase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01557"
SQ SEQUENCE 306 AA; 33270 MW; 93D6C63AEE0FA7EE CRC64;
MKEQPTPSWT SSKECAMRFA IYKKNGHRGI AVEHSGQWFG LTAEDTAYPG DLDSLLAQGA
DLAEVAARLA RGTPVDLDAV RVLPPFGRPN KILCVGLNYL DHSMETGFAK QTYPTVFARF
ASSLIGHDQP IALPAQSSQL DYEGELVAVI GKAGRGITRE RALDHVAGYS LFNDVTLRDY
QFRTPQWTMG KNFDGTGGFG PWFVTADELP RGCKGLRIQT RLNGAVVQEA STSDMIFDIE
TLVVMLSEVM TLQAGDLIVT GTPAGIGMAR EPQLWMKAGD VCEVEIEQLG VLRNAVMPAA
MVRCDA
//
