ID A2WA43_9BURK Unreviewed; 320 AA.
AC A2WA43; A0A0D5J1J1;
DT 20-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 20-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Isopropylmalate/homocitrate/citramalate synthases {ECO:0000313|EMBL:EAY68839.1};
GN ORFNames=BDAG_01573 {ECO:0000313|EMBL:EAY68839.1};
OS Burkholderia dolosa AU0158.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=350701 {ECO:0000313|EMBL:EAY68839.1, ECO:0000313|Proteomes:UP000053482};
RN [1] {ECO:0000313|Proteomes:UP000053482}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AU0158 {ECO:0000313|Proteomes:UP000053482};
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Devon K., Nusbaum C., Borowsky M.L.,
RA Jaffe D., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M.,
RA Mauceli E., Brockman W., Rounsley S., Young S., LaButti K., Pushparaj V.,
RA DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P.,
RA Pearson M., Howarth C., Kodira C., Zeng Q., Yandava C., Oleary S.,
RA Alvarado L., Lory S., LiPuma J.;
RT "The Genome Sequence of Burkholderia dolosa (strain AU0158).";
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HMG-CoA lyase family.
CC {ECO:0000256|ARBA:ARBA00009405}.
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DR EMBL; CH482380; EAY68839.1; -; Genomic_DNA.
DR RefSeq; WP_006764306.1; NZ_CP009795.1.
DR AlphaFoldDB; A2WA43; -.
DR GeneID; 64461170; -.
DR PATRIC; fig|350701.8.peg.1541; -.
DR HOGENOM; CLU_022138_3_2_4; -.
DR OrthoDB; 9784013at2; -.
DR Proteomes; UP000053482; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016833; F:oxo-acid-lyase activity; IEA:InterPro.
DR CDD; cd07938; DRE_TIM_HMGL; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR043594; HMGL.
DR InterPro; IPR000891; PYR_CT.
DR PANTHER; PTHR42738; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR PANTHER; PTHR42738:SF7; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
SQ SEQUENCE 320 AA; 33568 MW; 419ACFBEC6063D62 CRC64;
MHAPGKRTYI HEVATRDGFQ NEAAFVDTDA KIALVDALSA CGYAKIEVTS FTSPNAIPAL
RDAEAVMHGI ARAPGVVYTA LVPNVRGAER ALSCGVDEVN LVMSTSESHN RANLRMTREQ
SFAQLRDVIG ALRGSGVAIN VSLSTAMGCP MEGDVPAETV LAWMQRFAAL GVDGFTLCDT
TGMAFPSQVR DLCERARARF GTLQLTLHFH DTRAMALANT LAALDAGIDR FDASLGGLGG
CPYAPGATGN ACTEELVHML ALDGYDTGVD LAAVLAAAAT LPALVGHDVP SRLLKAGRRS
DLHPPPPADA AATPAQRAFR
//
