ID A3CMD9_STRSV Unreviewed; 345 AA.
AC A3CMD9;
DT 20-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 20-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=Zn-dependeant threonine dehydrogenase, putative {ECO:0000313|EMBL:ABN44344.1};
DE EC=1.1.1.1 {ECO:0000313|EMBL:ABN44344.1};
GN Name=adhB {ECO:0000313|EMBL:ABN44344.1};
GN OrderedLocusNames=SSA_0921 {ECO:0000313|EMBL:ABN44344.1};
OS Streptococcus sanguinis (strain SK36).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=388919 {ECO:0000313|EMBL:ABN44344.1, ECO:0000313|Proteomes:UP000002148};
RN [1] {ECO:0000313|EMBL:ABN44344.1, ECO:0000313|Proteomes:UP000002148}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK36 {ECO:0000313|EMBL:ABN44344.1,
RC ECO:0000313|Proteomes:UP000002148};
RX PubMed=17277061; DOI=10.1128/JB.01808-06;
RA Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P.,
RA Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D.,
RA Paik S., Peterson D.L., Macrina F.L., Buck G.A.;
RT "Genome of the opportunistic pathogen Streptococcus sanguinis.";
RL J. Bacteriol. 189:3166-3175(2007).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; CP000387; ABN44344.1; -; Genomic_DNA.
DR RefSeq; WP_011836798.1; NC_009009.1.
DR RefSeq; YP_001034894.1; NC_009009.1.
DR AlphaFoldDB; A3CMD9; -.
DR STRING; 388919.SSA_0921; -.
DR KEGG; ssa:SSA_0921; -.
DR PATRIC; fig|388919.9.peg.876; -.
DR eggNOG; COG1063; Bacteria.
DR HOGENOM; CLU_026673_11_3_9; -.
DR OrthoDB; 9769198at2; -.
DR Proteomes; UP000002148; Chromosome.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42813:SF2; DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED; 1.
DR PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ABN44344.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002148};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 26..123
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 179..288
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 345 AA; 36777 MW; 932DFA79ADEA7F6D CRC64;
MKLAVYTKAG QVGLADLDRP QIIEADDAII RIVRTCVCGS DLWRYRSPDI EAGHQNSGHE
AIGIVEEIGD TVTTVKPGDF VIAPFTHGCG QCDACRAGFD GTCDSHIGNN WSDGVQAEYM
RFEFANWALI KIPGQPSDYT EGMLKSLLTL ADVMPTGYHA ARVADVKPGD KVVVIGDGAV
GQCAVIAAKM RGASQIVLMS RHEDRQKMAL ESGATAVVAE RGEEGIAKVR EILGGGADAA
LECVGTEAAV DQALGVLHNG GRLGFVGVPH YNNRALGSTF AQNITVAGGA ASVTTYDKQI
LLKAVLDGDI NPGRVFTSSY KLEDIDQAYR DMDERKTIKS MIVFD
//
