ID A3CYB2_METMJ Unreviewed; 477 AA.
AC A3CYB2;
DT 20-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 20-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=Cardiolipin synthetase 2 {ECO:0000313|EMBL:ABN58362.1};
DE EC=2.7.8.- {ECO:0000313|EMBL:ABN58362.1};
GN OrderedLocusNames=Memar_2441 {ECO:0000313|EMBL:ABN58362.1};
OS Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanomicrobiaceae; Methanoculleus.
OX NCBI_TaxID=368407 {ECO:0000313|EMBL:ABN58362.1, ECO:0000313|Proteomes:UP000002146};
RN [1] {ECO:0000313|EMBL:ABN58362.1, ECO:0000313|Proteomes:UP000002146}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35101 / DSM 1498 / JR1
RC {ECO:0000313|Proteomes:UP000002146};
RX PubMed=21304656; DOI=10.4056/sigs.32535;
RA Anderson I.J., Sieprawska-Lupa M., Lapidus A., Nolan M., Copeland A.,
RA Glavina Del Rio T., Tice H., Dalin E., Barry K., Saunders E., Han C.,
RA Brettin T., Detter J.C., Bruce D., Mikhailova N., Pitluck S., Hauser L.,
RA Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C.;
RT "Complete genome sequence of Methanoculleus marisnigri Romesser et al. 1981
RT type strain JR1.";
RL Stand. Genomic Sci. 1:189-196(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP000562; ABN58362.1; -; Genomic_DNA.
DR RefSeq; WP_011845271.1; NC_009051.1.
DR AlphaFoldDB; A3CYB2; -.
DR STRING; 368407.Memar_2441; -.
DR GeneID; 76730521; -.
DR KEGG; mem:Memar_2441; -.
DR eggNOG; arCOG02039; Archaea.
DR HOGENOM; CLU_038053_1_1_2; -.
DR OrthoDB; 169510at2157; -.
DR Proteomes; UP000002146; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0008808; F:cardiolipin synthase activity; IEA:InterPro.
DR GO; GO:0032049; P:cardiolipin biosynthetic process; IEA:InterPro.
DR CDD; cd09110; PLDc_CLS_1; 1.
DR CDD; cd09112; PLDc_CLS_2; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR HAMAP; MF_01916; Cardiolipin_synth_Cls; 1.
DR InterPro; IPR030874; Cardiolipin_synth_Firmi.
DR InterPro; IPR022924; Cardiolipin_synthase.
DR InterPro; IPR027379; CLS_N.
DR InterPro; IPR025202; PLD-like_dom.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR NCBIfam; TIGR04265; bac_cardiolipin; 1.
DR PANTHER; PTHR21248; CARDIOLIPIN SYNTHASE; 1.
DR PANTHER; PTHR21248:SF22; PHOSPHOLIPASE D; 1.
DR Pfam; PF13091; PLDc_2; 2.
DR Pfam; PF13396; PLDc_N; 1.
DR SMART; SM00155; PLDc; 2.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR PROSITE; PS50035; PLD; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ABN58362.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 34..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 214..241
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT DOMAIN 390..417
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
SQ SEQUENCE 477 AA; 53374 MW; 0B1CAD3B92E19259 CRC64;
MELLLSIGFI LALNVVFAVT IVFFERRNPT ATTAWLVVLF LLPPVGFALY LFFGQNYTRQ
RMFVVKEHED RCFLQGVFER QHRALAGNHH RFATPAAEEF RDAIFLLLRN NRAYLTEGNR
VDVYTRGEDK FDALFAAIRG ARHSIHLEYF VINDDELGRA VVRALAEKAR EGVEVRLLFD
AMGSRAGGGS RKAFFELEDV GGKIGVFFPS VYRINYRNHR KIAVIDGTVG FIGGFNIGDD
YLGKGPLGCW RDTAVRITGE AVRMLQLRFF LDWNYVTGEY PGIETCYFPQ ESTPGATPVQ
IVSGGPDTRW NPIKEGYLKL INSARESICI QTPYFIPDES VADALRLAAL SGVDVRIMIP
CKPDHPFVYW ATLSFIGDLL DAGVRAYTYD GGFLHAKTIV VDGKAGSVGS ANWDVRSFRL
NFEANAFFYD AAVGADLVRA FEEDLAVCTE ITPENYLARS LAVRVKESVS RLFSPLG
//
