ID A3DL41_STAMF Unreviewed; 406 AA.
AC A3DL41;
DT 20-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 20-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=Dihydrothymine dehydrogenase {ECO:0000256|ARBA:ARBA00032722};
DE AltName: Full=Dihydrouracil dehydrogenase {ECO:0000256|ARBA:ARBA00030119};
GN OrderedLocusNames=Smar_0238 {ECO:0000313|EMBL:ABN69351.1};
OS Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1).
OC Archaea; Thermoproteota; Thermoprotei; Desulfurococcales;
OC Desulfurococcaceae; Staphylothermus.
OX NCBI_TaxID=399550 {ECO:0000313|EMBL:ABN69351.1, ECO:0000313|Proteomes:UP000000254};
RN [1] {ECO:0000313|Proteomes:UP000000254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43588 / DSM 3639 / JCM 9404 / F1
RC {ECO:0000313|Proteomes:UP000000254};
RX PubMed=19341479; DOI=10.1186/1471-2164-10-145;
RA Anderson I.J., Dharmarajan L., Rodriguez J., Hooper S., Porat I.,
RA Ulrich L.E., Elkins J.G., Mavromatis K., Sun H., Land M., Lapidus A.,
RA Lucas S., Barry K., Huber H., Zhulin I.B., Whitman W.B., Mukhopadhyay B.,
RA Woese C., Bristow J., Kyrpides N.;
RT "The complete genome sequence of Staphylothermus marinus reveals
RT differences in sulfur metabolism among heterotrophic Crenarchaeota.";
RL BMC Genomics 10:145-145(2009).
RN [2] {ECO:0000313|EMBL:ABN69351.1, ECO:0000313|Proteomes:UP000000254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43588 / DSM 3639 / JCM 9404 / F1
RC {ECO:0000313|Proteomes:UP000000254};
RX PubMed=21304655; DOI=10.4056/sigs.30527;
RA Anderson I.J., Sun H., Lapidus A., Copeland A., Glavina Del Rio T.,
RA Tice H., Dalin E., Lucas S., Barry K., Land M., Richardson P., Huber H.,
RA Kyrpides N.C.;
RT "Complete genome sequence of Staphylothermus marinus Stetter and Fiala 1986
RT type strain F1.";
RL Stand. Genomic Sci. 1:183-188(2009).
CC -!- SIMILARITY: Belongs to the dihydropyrimidine dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00010804}.
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DR EMBL; CP000575; ABN69351.1; -; Genomic_DNA.
DR RefSeq; WP_011838542.1; NC_009033.1.
DR AlphaFoldDB; A3DL41; -.
DR STRING; 399550.Smar_0238; -.
DR GeneID; 4906473; -.
DR KEGG; smr:Smar_0238; -.
DR eggNOG; arCOG00603; Archaea.
DR eggNOG; arCOG01543; Archaea.
DR HOGENOM; CLU_042042_4_3_2; -.
DR OrthoDB; 36608at2157; -.
DR Proteomes; UP000000254; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR Gene3D; 3.30.70.20; -; 2.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR005720; Dihydroorotate_DH_cat.
DR PANTHER; PTHR43073; DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]; 1.
DR PANTHER; PTHR43073:SF2; DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF01180; DHO_dh; 1.
DR Pfam; PF14697; Fer4_21; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000000254}.
FT DOMAIN 341..370
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 375..404
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
SQ SEQUENCE 406 AA; 44117 MW; EFF3BD8CC837D7CA CRC64;
MVSLEVEIAG LKMKNPLMNA ACPVSRDAEM MKALIDNGVG AVVAKTISVR PAIVPRPSMG
AVDRGIVRSQ ILKTFGPGNV RIVNADSGNY RFIYALLNAE LWSDIPAEHY FEREYPIVKK
YAEEKGVPFI ISIGYKPEEL QLLGPKCQKA GANAIEFSTH YIGKDYRPVV EAAKALREVV
DIPIFAKLSP FTPNIPELVK ELEKVGVDGI VATNTIGPAL HIDIETGLPI VGGPNGYGWM
SGPALKPLAL AVVAEAAKNT HLPVIGVGGI SKGTDVIEYF MAGASAVQIC TAALIEGLGV
FRRIEKEIES WLKRHGYDSI LDVKGKALKY LKPEPRRVWA KPPVVDPKKC IGCGFCEQVC
DYNAVKVVPN EEGKRIAQVN YDLCYGCGLC TSVCPTRAIH FEEELD
//
