ID A3DUJ4_XIPMA Unreviewed; 912 AA.
AC A3DUJ4;
DT 20-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 20-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=RB transcriptional corepressor 1 {ECO:0000313|Ensembl:ENSXMAP00000030748.1};
DE SubName: Full=Retinoblastoma susceptibility protein {ECO:0000313|EMBL:ABD78137.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|EMBL:ABD78137.1};
RN [1] {ECO:0000313|EMBL:ABD78137.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17011832; DOI=10.1016/j.cbpc.2006.07.013;
RA Butler A.P., Trono D., Coletta L.D., Beard R., Fraijo R., Kazianis S.,
RA Nairn R.S.;
RT "Regulation of CDKN2A/B and Retinoblastoma genes in Xiphophorus melanoma.";
RL Comp. Biochem. Physiol. C Toxicol. Pharmacol. 145:145-155(2007).
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [4] {ECO:0000313|Ensembl:ENSXMAP00000030748.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000030748.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR EMBL; DQ418730; ABD78137.1; -; mRNA.
DR RefSeq; NP_001273236.1; NM_001286307.2.
DR STRING; 8083.ENSXMAP00000030748; -.
DR Ensembl; ENSXMAT00000036253.1; ENSXMAP00000030748.1; ENSXMAG00000015729.2.
DR GeneID; 102230233; -.
DR KEGG; xma:102230233; -.
DR CTD; 5925; -.
DR GeneTree; ENSGT00950000183202; -.
DR HOGENOM; CLU_008943_2_0_1; -.
DR OMA; VKDIGCI; -.
DR OrthoDB; 519973at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0051172; P:negative regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20599; CYCLIN_RB; 1.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 6.10.140.1380; -; 1.
DR Gene3D; 6.10.250.530; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR015030; RB_C.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742:SF17; RETINOBLASTOMA-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR Pfam; PF08934; Rb_C; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SMART; SM01369; Rb_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 2: Evidence at transcript level;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Cyclin {ECO:0000256|ARBA:ARBA00023127};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 91..214
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 359..562
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT DOMAIN 652..739
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 760..912
FT /note="Retinoblastoma-associated protein C-terminal"
FT /evidence="ECO:0000259|SMART:SM01369"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..894
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 895..912
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 912 AA; 103867 MW; 121BFF32BEB0130B CRC64;
MPPKKRHSGT TQNKEPKPSA DSASPPDKQD SPELSEKKHR EKHAEFVSLC KSLHVSDLVC
DRAWTLWESV RESMDKVPGS QQRLWGACLF VIITDMDTGS FTVTQVLKAV SLNLKQFLAL
VRQLDVNLDT ISMKVNSALT RLEKKYDVML ALYQRFEKTC KNIFVLTSDG RERETMRTCW
TMFLLAKGRA LQMEDDLVIS FQLLLCTLEL FIKRCSSDQL QSLYQSAISK VLSPPTRTSR
RNQSKAKSRP SEPEVDAQLL ETLCKDNECN FEEVKNVYQT SFLAFLDSTD LSRSIDFPQV
NDVNQQYEEL YLKSRDIDGR LFFDGDETVL PPKFEISKVE RTPKKNQPEE DGPMIPPQTP
IRAAMTSIRM LRGDLPSNGD QPSTTLTTYF KNCTVDPTQD VQKRLETLGQ VFSQKFGEAV
GPHCVVYGRQ RFALGVRLYY KVMEAMLKSE EKRLSVQNFS KLLNDFTFHT SLLACSLEVV
MATYEESSFK NGGSDQTGTN LCFPWILNVL NLSAFDFYKV IESFIKAEPT LSKDIIKHLE
TCENLIMERI AWRTGSPLFE LLKQEHASAA AEPVETPASF SQPLQHSHTA ADLYLTPTRP
ASRVLPPDSP ATPPQQPTAS QSTSQAPCQA PRQPKSNSLS LFYKKLYRLA YTRLKTLCSY
LLSSHPELEP IIWTLFQYTL QHEYELMRDR HLDQLMMSAM YAICKVKSVD LRFKSIVSAY
KNMTNTNQET FKNVLIIEGH YDSIIVFYNQ VFMQKLKTNI LQHASIRPPP LSPIPQIPRS
PYKLPNSPLR VPGSNNIYIS PLRSSRMSPG IMTPRSRMLV SIGESFGLGN RFQKINQMVN
SERSHKRTMD QSAAIKPLKK LRFDVDGQDE ADGSKPGGDS TLIQKLTEMS STWSRMHEQK
MKEEPETRDE PQ
//
