ID A3FQ60_CRYPI Unreviewed; 314 AA.
AC A3FQ60;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=Mitochondrial carrier protein, putative {ECO:0000313|EMBL:EAZ51369.1};
GN ORFNames=cgd2_1030 {ECO:0000313|EMBL:EAZ51369.1};
OS Cryptosporidium parvum (strain Iowa II).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX NCBI_TaxID=353152 {ECO:0000313|EMBL:EAZ51369.1, ECO:0000313|Proteomes:UP000006726};
RN [1] {ECO:0000313|EMBL:EAZ51369.1, ECO:0000313|Proteomes:UP000006726}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Iowa II {ECO:0000313|Proteomes:UP000006726};
RX PubMed=15044751; DOI=10.1126/science.1094786;
RA Abrahamsen M.S., Templeton T.J., Enomoto S., Abrahante J.E., Zhu G.,
RA Lancto C.A., Deng M., Liu C., Widmer G., Tzipori S., Buck G.A., Xu P.,
RA Bankier A.T., Dear P.H., Konfortov B.A., Spriggs H.F., Iyer L.,
RA Anantharaman V., Aravind L., Kapur V.;
RT "Complete genome sequence of the apicomplexan, Cryptosporidium parvum.";
RL Science 304:441-445(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAZ51369.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAEE01000005; EAZ51369.1; -; Genomic_DNA.
DR RefSeq; XP_001388196.1; XM_001388159.1.
DR AlphaFoldDB; A3FQ60; -.
DR STRING; 353152.A3FQ60; -.
DR EnsemblProtists; EAZ51369; EAZ51369; cgd2_1030.
DR GeneID; 3373423; -.
DR KEGG; cpv:cgd2_1030; -.
DR VEuPathDB; CryptoDB:cgd2_1030; -.
DR InParanoid; A3FQ60; -.
DR OMA; MYNSQHQ; -.
DR OrthoDB; 5481380at2759; -.
DR Proteomes; UP000006726; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0048250; P:iron import into the mitochondrion; IEA:UniProt.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 2.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR45758:SF4; MITOFERRIN-1; 1.
DR PANTHER; PTHR45758; MITOFERRIN-1-RELATED; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000006726};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT TRANSMEM 181..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 15..99
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 127..209
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 219..313
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 314 AA; 34840 MW; 2BAF23900B46FB13 CRC64;
MEKDIEDWEI WKGDIPFWKH SLAGSIAGVM EHSCFFPLDT IKTCLQSGKV DGLTGNRGMI
AFIRSNGARA LFRGFPAVVF GNVPAHASMF TTYEFSKRLM SKITKKLEKR AESKSSLLHD
ANTSIFNSVV SPAICGGLST ISHDIIATPL DVIKQRLQVG SYKGMADCII TMFKREGIRS
FYRSLPITLF MNIPQTGLFV LLNENLKSLF GKNKDDLLKQ NTFNFVIAGI SGGTAAFITN
PLDLIKTKLQ TQACHVSQKE TLRVVYPSVK KAFIDTLRKQ GIRGMYSGAL ARSLLIAPSY
ALCWGTYETV KNFL
//
