ID   A3FQF8_CRYPI            Unreviewed;       729 AA.
AC   A3FQF8;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   03-APR-2007, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   SubName: Full=Carboxylesterase, putative {ECO:0000313|EMBL:EAZ51357.1};
GN   ORFNames=cgd1_3290 {ECO:0000313|EMBL:EAZ51357.1};
OS   Cryptosporidium parvum (strain Iowa II).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX   NCBI_TaxID=353152 {ECO:0000313|EMBL:EAZ51357.1, ECO:0000313|Proteomes:UP000006726};
RN   [1] {ECO:0000313|EMBL:EAZ51357.1, ECO:0000313|Proteomes:UP000006726}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Iowa II {ECO:0000313|Proteomes:UP000006726};
RX   PubMed=15044751; DOI=10.1126/science.1094786;
RA   Abrahamsen M.S., Templeton T.J., Enomoto S., Abrahante J.E., Zhu G.,
RA   Lancto C.A., Deng M., Liu C., Widmer G., Tzipori S., Buck G.A., Xu P.,
RA   Bankier A.T., Dear P.H., Konfortov B.A., Spriggs H.F., Iyer L.,
RA   Anantharaman V., Aravind L., Kapur V.;
RT   "Complete genome sequence of the apicomplexan, Cryptosporidium parvum.";
RL   Science 304:441-445(2004).
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. AB hydrolase 2
CC       family. {ECO:0000256|ARBA:ARBA00006499}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAZ51357.1}.
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DR   EMBL; AAEE01000006; EAZ51357.1; -; Genomic_DNA.
DR   RefSeq; XP_001388180.1; XM_001388143.1.
DR   AlphaFoldDB; A3FQF8; -.
DR   STRING; 353152.A3FQF8; -.
DR   EnsemblProtists; EAZ51357; EAZ51357; cgd1_3290.
DR   GeneID; 3371389; -.
DR   KEGG; cpv:cgd1_3290; -.
DR   VEuPathDB; CryptoDB:cgd1_3290; -.
DR   InParanoid; A3FQF8; -.
DR   OMA; EDNCAKI; -.
DR   OrthoDB; 4670340at2759; -.
DR   Proteomes; UP000006726; Chromosome 1.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR003140; PLipase/COase/thioEstase.
DR   PANTHER; PTHR10655; LYSOPHOSPHOLIPASE-RELATED; 1.
DR   PANTHER; PTHR10655:SF17; PALMITOYL-PROTEIN HYDROLASE; 1.
DR   Pfam; PF02230; Abhydrolase_2; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006726};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          58..268
FT                   /note="Phospholipase/carboxylesterase/thioesterase"
FT                   /evidence="ECO:0000259|Pfam:PF02230"
FT   REGION          381..403
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          447..487
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          540..635
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        540..599
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   729 AA;  83368 MW;  093BAA25DA4C9135 CRC64;
     MLSLEIQRKI PRIYVIFIIF IIFFSNVECL LKKANQTVKF KKGDTNGGYG LNFTPSNYQN
     VIVWLHGLCS SAVEWERFLI LVNKKDFLPN TKWIIPTSKY RKITAIYGNE CPAWFNITSF
     SPTENIEDIN GILESVKRIR NIIKSEIDLG IDQSRIFLIG FSQGSAMALI TSMIMRDITI
     GGVIGVSGWI PMISHLSLGK DSPLNNEIFD FNVSDEKKQN TRVYIFHGSK DKLIPFHIFL
     QTSIFMSTEL EIQNINQRMY YNIGHTITAM QGIHIMYEIS KMIDSENIHE ELTAVQLSTL
     SNSSYSMILK VTDPMDCNYT YYKFMPCNPN QQGKLLCNNI NCNCTDMLYF YDKSKFFENL
     NHRDFGQNKY PYAIIQAIPS ENNKKKRNNN NNSNNKEDES QDFELTNIKI NEKDNENVST
     LLSNINVNGN ESIKDNFVSG NDINQAIMND DNDNDDDNSN NNDNSDLKDQ ISKNSHNSLR
     RRNTSLNNIS QRYLMSINNE KNDNSSDSSS IVDYHDKLYI SLRGNGSEDI ENDNDEYVDK
     QERDQEDQVK HMDENEDKQK EEKKQKQEKN VREEEGKGRE EEEGKGKGKE EGKEEGKGEE
     GEQEGEEGEE GEEKGERGAG GKEEEQQEMN ITSTLASPVD QIISDELNTS NKIFSTKISH
     YSKTPLKVKH YIVSDKDNSK EGEDTNMGEN GNGIFNIGKY IDSLYNQSRD SINANNTIIS
     NIYESEVGN
//