ID A3KG41_MOUSE Unreviewed; 249 AA.
AC A3KG41;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=Inhibitor of kappaB kinase gamma {ECO:0000313|Ensembl:ENSMUSP00000116615.2};
DE Flags: Fragment;
GN Name=Ikbkg {ECO:0000313|Ensembl:ENSMUSP00000116615.2,
GN ECO:0000313|MGI:MGI:1338074};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000116615.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000116615.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000116615.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000116615.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000116615.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A3KG41; -.
DR SMR; A3KG41; -.
DR MaxQB; A3KG41; -.
DR ProteomicsDB; 306102; -.
DR Antibodypedia; 73338; 1441 antibodies from 47 providers.
DR Ensembl; ENSMUST00000135165.8; ENSMUSP00000116615.2; ENSMUSG00000004221.17.
DR AGR; MGI:1338074; -.
DR MGI; MGI:1338074; Ikbkg.
DR VEuPathDB; HostDB:ENSMUSG00000004221; -.
DR GeneTree; ENSGT00530000063808; -.
DR OMA; VAMRKNF; -.
DR ChiTaRS; Ikbkg; mouse.
DR Proteomes; UP000000589; Chromosome X.
DR Bgee; ENSMUSG00000004221; Expressed in left lobe of liver and 268 other cell types or tissues.
DR ExpressionAtlas; A3KG41; baseline and differential.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 2.
DR InterPro; IPR021063; NEMO_N.
DR PANTHER; PTHR31553; NF-KAPPA-B ESSENTIAL MODULATOR; 1.
DR PANTHER; PTHR31553:SF3; NF-KAPPA-B ESSENTIAL MODULATOR; 1.
DR Pfam; PF11577; NEMO; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0007829|EPD:A3KG41,
KW ECO:0007829|MaxQB:A3KG41};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 44..111
FT /note="NF-kappa-B essential modulator NEMO N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11577"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 51..240
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 249
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000116615.2"
SQ SEQUENCE 249 AA; 28936 MW; 27B4A3B311522DA1 CRC64;
MNKHPWKNQL SEMVQPSGGP AEDQDMLGEE SSLGKPAMLH LPSEQGTPET LQRCLEENQE
LRDAIRQSNQ MLRERCEELL HFQVSQREEK EFLMCKFQEA RKLVERLSLE KLDLRSQREQ
ALKELEQLKK CQQQMAEDKA SVKAQVTSLL GELQESQSRL EAATKDRQAL EGRIRAVSEQ
VRQLESEREV LQQQHSVQVD QLRMQNQSVE AALRMERQAA SEEKRKLAQL QAAYHQLFQD
YDSHIKSSK
//
