ID A3KMV0_BOVIN Unreviewed; 490 AA.
AC A3KMV0;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 24-JAN-2024, entry version 83.
DE RecName: Full=[histone H3]-lysine(4) N-trimethyltransferase {ECO:0000256|ARBA:ARBA00012182};
DE EC=2.1.1.354 {ECO:0000256|ARBA:ARBA00012182};
GN Name=SMYD1 {ECO:0000313|EMBL:AAI33279.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI33279.1};
RN [1] {ECO:0000313|EMBL:AAI33279.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hereford {ECO:0000313|EMBL:AAI33279.1};
RC TISSUE=Heart ventrical {ECO:0000313|EMBL:AAI33279.1};
RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA Holt R., Jones S.J., Marra M.A.;
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) +
CC N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60260, Rhea:RHEA-COMP:15537, Rhea:RHEA-
CC COMP:15547, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.354;
CC Evidence={ECO:0000256|ARBA:ARBA00000944};
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DR EMBL; BC133278; AAI33279.1; -; mRNA.
DR RefSeq; NP_001076953.1; NM_001083484.1.
DR AlphaFoldDB; A3KMV0; -.
DR GeneID; 537404; -.
DR KEGG; bta:537404; -.
DR CTD; 150572; -.
DR OrthoDB; 166337at2759; -.
DR GO; GO:0042800; F:histone H3K4 methyltransferase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd10526; SET_SMYD1; 1.
DR Gene3D; 1.10.220.160; -; 1.
DR Gene3D; 1.25.40.970; -; 1.
DR Gene3D; 6.10.140.2220; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044418; SMYD1_SET.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR12197; HISTONE-LYSINE N-METHYLTRANSFERASE SMYD; 1.
DR PANTHER; PTHR12197:SF184; HISTONE-LYSINE N-METHYLTRANSFERASE SMYD1; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00134}.
FT DOMAIN 7..253
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 52..90
FT /note="MYND-type"
FT /evidence="ECO:0000259|PROSITE:PS50865"
SQ SEQUENCE 490 AA; 56329 MW; B108B9993FE21038 CRC64;
MTIGGMENVE VFTAEGKGRG LKATKEFCAA DIIFAERAYS AVVFDSLVNV VCHTCFKRQE
KLHRCGQCKF AHYCDRTCQK DAWLNHKNEC SAIKRYGKVP NENIRLAARI MWRVEREGSG
LTEGCLVSVD DLQNHVEHFG EEEQKELRLD VDTFLQYWPP QSQQFSMQYI SHIFGVINCN
GFTLSDQRGL QAVGVGVFPN LALVNHDCWP NCTVIFNNGN HEAVKSMFHT QMRIELRALG
KISEGEELTV SYIDFLNVSE ERKKQLKRQY YFDCTCEHCQ KGLKDDLFLG VKDNPKPSQE
VVKEMIQFSK DTLEKIDKAR SEGLYHEVVK LCRECLQKQE PVFADTNIYT LRLLSIVSEV
LSYLQAFEEA SHYARRMVDG YMKLYHHNNA QLGMAIMRAG LTNWHAGNIE VGHGMICKAY
AILLVTHGPS HPITKDLEAM RMQTEMELRM FRQNEFMYHK MREAALNNQP MQVMAEPSKE
PAPALFHKKQ
//
