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Database: UniProt
Entry: A3LNF3_PICST
LinkDB: A3LNF3_PICST
Original site: A3LNF3_PICST 
ID   A3LNF3_PICST            Unreviewed;       366 AA.
AC   A3LNF3;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   03-APR-2007, sequence version 1.
DT   24-JAN-2024, entry version 82.
DE   RecName: Full=enoyl-[acyl-carrier-protein] reductase {ECO:0000256|ARBA:ARBA00038963};
DE            EC=1.3.1.104 {ECO:0000256|ARBA:ARBA00038963};
GN   Name=ETR2 {ECO:0000313|EMBL:ABN64846.1};
GN   ORFNames=PICST_34892 {ECO:0000313|EMBL:ABN64846.1};
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104 {ECO:0000313|EMBL:ABN64846.1, ECO:0000313|Proteomes:UP000002258};
RN   [1] {ECO:0000313|EMBL:ABN64846.1, ECO:0000313|Proteomes:UP000002258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545
RC   {ECO:0000313|Proteomes:UP000002258};
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] +
CC         H(+) + NADPH; Xref=Rhea:RHEA:22564, Rhea:RHEA-COMP:9925, Rhea:RHEA-
CC         COMP:9926, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:78784, ChEBI:CHEBI:78785; EC=1.3.1.104;
CC         Evidence={ECO:0000256|ARBA:ARBA00035831};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. Quinone oxidoreductase subfamily.
CC       {ECO:0000256|ARBA:ARBA00010371}.
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DR   EMBL; CP000496; ABN64846.1; -; Genomic_DNA.
DR   RefSeq; XP_001382875.1; XM_001382838.1.
DR   AlphaFoldDB; A3LNF3; -.
DR   STRING; 322104.A3LNF3; -.
DR   GeneID; 4836725; -.
DR   KEGG; pic:PICST_34892; -.
DR   eggNOG; KOG0025; Eukaryota.
DR   HOGENOM; CLU_026673_17_0_1; -.
DR   InParanoid; A3LNF3; -.
DR   OMA; YGYTQSK; -.
DR   OrthoDB; 6213at2759; -.
DR   Proteomes; UP000002258; Chromosome 2.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd08290; ETR; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR43981; ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43981:SF2; ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002258};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT   DOMAIN          17..355
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   366 AA;  39911 MW;  C0064E4B22D1C4D3 CRC64;
     MITAQAVVYS EHGEPKDVLR THTYEIDDDK IAANQIIVKT LGSPVNPSDI NQIQGVYPSK
     PDKTTELGTS EPSAPCGNEG LFEIIKVGSN VSNFKVGDWA VPSNVNFGTW RTHALATEDQ
     FTRLPNPEQS KAAGKPSGLT INQGATILVN PMTAYLMLTH YVQLIPGKDW FIQNGGNSAV
     GKYAIQISKL LGFNSISVVR DRPNLNELES ELKGLGATQV ITEEQNGSRE FGPTIKNWVK
     ETGGEIKLAL NCVGGKNSTG VARKLANNGL MLTYGGMSFQ PVILPTSLHI FKNITSAGFW
     ITALLKNDEE LKNKTLSKIV EWYENEQLVD AKSLETPFVA GGAKQLHEYY QEAVVNSAKG
     KQLITY
//
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